Short antibiotic treatment courses or how short is short?

Rubinstein, Ethan

doi:10.1016/j.ijantimicag.2007.06.017

Cited by 43 publications

(34 citation statements)

References 15 publications

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“…5 Frequency of prescribing is usually mentioned in the known resources for antibiotic prescribing whereas duration of treatment recommended in therapeutic guidelines is most commonly based on expert opinion. 6,7 Inappropriate prescribing of antimicrobials may be associated with unfavorable side effects ranging from gastrointestinal disturbances to fatal anaphylactic shock and especially development of resistance. 8 Consequently, surveillance of antimicrobial resistance, monitoring of antibiotic usage and attempts to improve prescribing attitudes have become crucial.…”

Section: Introductionmentioning

confidence: 99%

Prescription pattern of antimicrobial agents by dental practitioners: a questionnaire based study

Gour

Kohli

Advani

et al. 2013

Int J Basic Clin Pharmacol

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Background: The aim of this study was to know the pattern & rationality of antimicrobial prescription by dental practitioners. Methods: It was questionnaire based cross sectional study. A total of 175 questionnaires were distributed to dental practitioners working in a tertiary care Dental College & Hospital and private practitioners in Jaipur (Rajasthan). The questionnaire contained questions about years of practice, diagnosis for which antimicrobial were prescribed, dosage and duration of antimicrobial drugs for prophylaxis, acute and chronic conditions, patient compliance & adverse effects. Data was expressed as counts and percentages. Results: Out of 175 questionnaires distributed, 150 were included in the study. 78% dentists had practices less than 5 years duration. Most common indications for which antimicrobials were prescribed were abscess, cellulitis, irreversible pulpitis, and acute gingivitis. Most common antimicrobials used for prophylaxis were Amoxycillin and Metronidazole. For the treatment of acute and chronic conditions, Amoxycillin, Metronidazole, Ofloxacin and Ornidazole alone or in combination were used. Only 20% dentist advised culture & sensitivity tests. 74% patients completed the recommended course of antimicrobials. 56% patients reported adverse drug reactions (ADRs) with the most common being nausea and vomiting, but only 13% dentists reported them to proper authorities. Conclusions: In this study, Amoxycillin and Metronidazole were the most common drugs used for the management of oral diseases, but were prescribed without culture & sensitivity in most cases. 56% patients reported ADRs, but only 13% dentists reported them to proper authorities. Appropriate measures need to be taken to promote rational prescribing and ADR reporting. [Int J Basic Clin Pharmacol 2013; 2(3.000): 311-314

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Section: Introductionmentioning

confidence: 99%

Prescription pattern of antimicrobial agents by dental practitioners: a questionnaire based study

Gour

Kohli

Advani

et al. 2013

Int J Basic Clin Pharmacol

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“…104 However, in recent years, groups of experts have suggested to keep antimicrobial therapy as short as possible, and the available body of evidence seems to support this concept. [105][106] In a recent meta-analysis Havey et al found no significant differences in clinical cure, microbiologic cure, and survival among bacteraemic patients receiving shorter (5-7 days) vs. longer (7-21 days) duration of therapy, irrespective of the source of infection. The major limitation of this systematic review was the lack of studies specifically targeting bacteraemic patients and critically ill ones.…”

Section: Duration Of Therapymentioning

confidence: 99%

Bloodstream infections in the Intensive Care Unit

2016

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Bloodstream infections (BSIs) represent a common complication among critically ill patients and a leading cause of morbidity and mortality. The prompt initiation of an effective antibiotic therapy is necessary in order to reduce mortality and to improve clinical outcomes. However, the choice of the empiric antibiotic regimen is often challenging, due to the worldwide spread of multi-drug resistant (MDR) organisms with reduced susceptibility to the available broad-spectrum antimicrobials. New therapeutic strategies are 5 to improve the effectiveness of antibiotic treatment while minimizing the risk of resistance selection.

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“…Dergelijk beleid is gebaseerd op onderzoeken waarin wordt gepleit voor de toepassing van kortdurende antibiotische behandelingen (Rubinstein, 2007). Gesuggereerd wordt dat een korte behandeling eff ectief kan zijn, mits er wordt behandeld met een bactericide middel in een zo hoog mogelijke concentratie (Rubinstein, 2007).…”

Section: Welke Doseringen En Hoe Lang?unclassified

“…Gesuggereerd wordt dat een korte behandeling eff ectief kan zijn, mits er wordt behandeld met een bactericide middel in een zo hoog mogelijke concentratie (Rubinstein, 2007). Daarnaast wordt voor tijdafh ankelijke antibiotica een T > MIC van 50-60% geadviseerd (Rubinstein, 2007). Dit alles sluit echter niet goed aan bij de door Abraham-Inpijn beschreven antibiotische voorkeursdoseringen (Abraham-Inpijn, 2015).…”

Section: Welke Doseringen En Hoe Lang?unclassified

Medicines and oral health care 2. An optimised antibiotic policy in the interest of the patient

Siebers¹

2016

NTvT

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InleidingAntibiotica zijn belangrijke geneesmiddelen bij de behandeling van infectieuze aandoeningen. Correct en restrictief gebruik van deze middelen is essentieel. Voor het verkrijgen van een optimaal behandeleff ect dient aan een aantal factoren te worden voldaan: juiste indicatie, correcte doseringen en therapietrouw. Als een behandeling op één of meerdere van deze punten tekortschiet dan kan dit leiden tot therapiefalen, maar ook tot de ontwikkeling van resis tente microorganismen. Dit laatste is een zeer urgent probleem in de hedendaagse gezondheidszorg (Olofsson en Cars, 2007; Andersson en Hughes, 2014;Rijksoverheid, 2015).Met dit artikel wordt inzicht gegeven in farmacodynamische en farmacokinetische parameters die van belang zijn bij de antimicrobiële behandeling van infectieziekten. Verder worden aanbevelingen gedaan voor optimalisering van het antibioticabeleid binnen de tandheelkunde. Hierbij staan het behandelresultaat en de resistentieproblematiek centraal. Wat bepaalt een correcte dosering?De therapierespons op een antibioticumbehandeling wordt bepaald door de antibiotische gevoeligheid van het microorganisme en door farmacologische parameters. Deze farmacologische eigenschappen kunnen in 2 klassen worden onderverdeeld (Drusano, 2004; Ambrose et al, 2007; Olofsson en Cars, 2007)

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Short antibiotic treatment courses or how short is short?

Cited by 43 publications

References 15 publications

Prescription pattern of antimicrobial agents by dental practitioners: a questionnaire based study

Prescription pattern of antimicrobial agents by dental practitioners: a questionnaire based study

Bloodstream infections in the Intensive Care Unit

Medicines and oral health care 2. An optimised antibiotic policy in the interest of the patient

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