Black hairy tongue (BHT) is a benign disease characterized by elongated filiform lingual papillae, with a carpet-like appearance of the dorsum of the tongue. It is has been reported to occur with a prevalence ranging from 0.6% to 11.3%. Although its etiology is not fully understood, BHT may be triggered by smoking, excessive coffee or black tea drinking, poor oral hygiene, trigeminal neuralgia, general debilitation, dry mouth as well as certain drugs. We present here a case of a patient with psychosis, depression, and benign prostatic hyperplasia, who developed BHT following treatment with a fixed dose combination (FDC) of olanzapine and fluoxetine and recovered within 3 months after withdrawal of treatment with FDC.

Background: The aim of this study was to know the pattern & rationality of antimicrobial prescription by dental practitioners. Methods: It was questionnaire based cross sectional study. A total of 175 questionnaires were distributed to dental practitioners working in a tertiary care Dental College & Hospital and private practitioners in Jaipur (Rajasthan). The questionnaire contained questions about years of practice, diagnosis for which antimicrobial were prescribed, dosage and duration of antimicrobial drugs for prophylaxis, acute and chronic conditions, patient compliance & adverse effects. Data was expressed as counts and percentages. Results: Out of 175 questionnaires distributed, 150 were included in the study. 78% dentists had practices less than 5 years duration. Most common indications for which antimicrobials were prescribed were abscess, cellulitis, irreversible pulpitis, and acute gingivitis. Most common antimicrobials used for prophylaxis were Amoxycillin and Metronidazole. For the treatment of acute and chronic conditions, Amoxycillin, Metronidazole, Ofloxacin and Ornidazole alone or in combination were used. Only 20% dentist advised culture & sensitivity tests. 74% patients completed the recommended course of antimicrobials. 56% patients reported adverse drug reactions (ADRs) with the most common being nausea and vomiting, but only 13% dentists reported them to proper authorities. Conclusions: In this study, Amoxycillin and Metronidazole were the most common drugs used for the management of oral diseases, but were prescribed without culture & sensitivity in most cases. 56% patients reported ADRs, but only 13% dentists reported them to proper authorities. Appropriate measures need to be taken to promote rational prescribing and ADR reporting. [Int J Basic Clin Pharmacol 2013; 2(3.000): 311-314

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Solvent extractions of shade dried seeds of Cyamopsis tetragonoloba, Pithecellobium dulce and Coriandrum sativum plants were executed using organic solvents. The obtained extracted crudes were subjected to the chemical analysis followed by instrumental analysis using standard procedures to identify the naturally occurring phytochemicals [1, 2, 3,]. Limonene, Oleanolic acid and Linalool were obtained from ethanol extracts of Cyamopsistetragonoloba, methanol extract of Pithecellobium dulce and acetone extract of Coriandrumsativum respectively. The compound identification were confirmed by 1H NMR, 13C NMR, IR and Mass spectroscopy [4]. The anti-cancer activity of the extracted terpenes determined using in-vitro analysis on HeLa-Human cervix cell lines. The obtained IC50 value of Oleanolic acid shows better biological activity against HeLa cell lines. It was also found that there is no cell lysis in HeLa cell lines in case of Limonene with concentration less than 30 μg. However, biological activity of Linalool is better in case of HeLa cell line. This suggests that Oleanolic acid and Linalool is good anti-cancer agent as reported from in vitro studies against Hela-Human cervix cell line.

Across the globe, India has second prevalent diabetic people. The effect of diabetes mellitus associated with various long term comorbid conditions. Chances of increases in blood pressure or hypertension affect 70% of diabetic patients. Dyslipidemia is often concomitant with diabetes and is correlated to an increased risk of CVD. The study aimed to evaluate the occurrence of comorbidities among type 2 diabetes patients and its pharmacotherapy. It was a cross-sectional observational study carried out on patients who were 18 years and above with a diagnosis of diabetes type 2 with comorbidity. The data was recorded, medication status of all patients was reviewed, organized, and expressed as counts and percentages. Out of 142 subjects 55.63 % (n = 79) were males, 44.36 % (n = 63) were females and mean age of the sample was 56.84 (± 11.24) years. Out of 142 patients, 88.02 % (125) were concomitant with severe complications like ischemic heart disease, hypertension, and hyperlipidemia remaining 13.6% (17) were associated with other complications. The most commonly prescribed drugs for hypertension were telmisartan (46 %), followed by telmisartan and amlodipine (22 %). In ischemic heart disease, the most common combination of aspirin and atorvastatin (76.92 %) was prescribed. In hyperlipidemia, atorvastatin (50 %) was prescribed most commonly. The present study results suggest the significance of various combinations of comorbidity could shed light on a probable common etiology, and then on probably protective measures.