Short- and long-term reproducibility of radioisotopic examination of gastric emptying

Jonderko, Krzysztof

doi:10.1016/0883-2897(90)90056-7

Cited by 16 publications

(17 citation statements)

References 18 publications

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“…Methods used for the assessment of gastrointestinal motility events cannot be exempted from this scrutiny. Accordingly, more and more papers are published on reproducibility of manometry, transit studies, examinations with the use of a barostat, etc 3–6 . Attempts have been made in the past to assess the reproducibility of electrogastrography.…”

Section: Introductionmentioning

confidence: 99%

How reproducible is cutaneous electrogastrography? An in‐depth evidence‐based study¹

Jonderko

Kasicka-Jonderko

Krusiec-Świdergoł

et al. 2005

Neurogastroenterology Motil

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Section: Introductionmentioning

confidence: 99%

How reproducible is cutaneous electrogastrography? An in‐depth evidence‐based study¹

Jonderko

Kasicka-Jonderko

Krusiec-Świdergoł

et al. 2005

Neurogastroenterology Motil

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“…The reproducibility of the breath test parameters is expressed in terms of the coefficient of variation for paired examinations, CV p [11,12]. Moreover, the data were subjected to the Bland and Altman statistic for calculation of the repeatability coefficients and check for a proportional or fixed bias [13,14].…”

Section: Discussionmentioning

confidence: 99%

13C-α-Ketoisocaproic Acid Breath Test Revisited: An In-Depth Reproducibility Study Advocates an Extended Breath Sampling Period

et al. 2007

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In this study we sought for a quantitative parameter which would offer the best reproducibility of a standard (13)C-alpha-ketoisocaproic acid ((13)C-KICA) breath test. On 3 separate days 14 healthy volunteers (7 females, 7 males) took orally 1 mg/kg body mass (13)C-KICA and 20 mg/kg body mass L-leucine. Samples of expiratory air for (13)CO(2) measurement with the use of isotope ratio mass spectrometry were collected every 5 min during the first hour and then at 70, 80, 90, 105, 120, 150, 180, 240, 300, 360, 540, 720, and 1440 min. Short-term reproducibility assessment involved paired examinations taken 3.5 days apart; paired examinations separated by 22 days (median) served for the medium-term reproducibility assessment. T(max), the time to reach the maximum momentary (13)C recovery (D(max)), showed an unsatisfactory reproducibility, and the D(max) displayed a fairly good reproducibility, whereas the cumulative (13)C recovery calculated for a time span within the range 0-90 and 0-120 min exhibited the best reproducibility. In no case did the medium-term reproducibility prove any worse than the short-term one. Taking into account its reproducibility, the cumulative (13)C recovery appears to be the most reliable parameter of the (13)C-KICA breath test.

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“…Without any doubt provision of reproducible measurement results is a feature of paramount importance, expected to be assured by methods designed for research and/or clinical applications in medicine [28,[31][32][33] . Breath tests performed with the use of stable isotopes, such as 13 C, cannot be considered an exception in this respect, especially because during the past decade their clinical use has been constantly growing [24,34,35] .…”

Section: Discussionmentioning

confidence: 99%

“…In addition the reproducibility of breath test parameters was expressed in terms of the coefficient of variation for paired examinations, CVp [27,28] . Sets of absolute values of individual differences in paired measurements were compared with the use of the paired or unpaired t test (where appropriate) in order to check if factors such as the time gap between the examinations, or the gender of the subjects affected the reproducibility.…”

Section: Discussionmentioning

confidence: 99%

¹³C-methacetin breath test reproducibility study reveals persistent CYP1A2 stimulation on repeat examinations

Kasicka-Jonderko

A²,

Jonderko³

et al. 2011

WJG

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METHODS:Twenty healthy volunteers (10 female, 10 male) underwent the 13 C-MBT after intake of 75 mg 13 C-methacetin p.o. on three occasions. Short-and medium-term reproducibility was assessed with paired examinations taken at an interval of 2 and 18 d (medians), respectively. RESULTS:The reproducibility of the 1-h cumulative 13 C recovery (AUC0-60), characterized by a coefficient of variation of 10%, appeared to be considerably better than the reproducibility of the maximum momentary 13 C recovery or the time of reaching it. Remarkably, as opposed to the short gap between consecutive examinations, the capacity of the liver to handle 13 C-methacetin increased slightly but statistically significantly when a repeat dose was administered after two to three weeks.Regarding the AUC0-60, the magnitude of this fixed bias amounted to 7.5%. Neither the time gap between the repeat examinations nor the gender of the subjects affected the 13 C-MBT reproducibility. CONCLUSION:13 C-MBT is most reproducibly quantified by the cumulative 13 C recovery, but the exactitude thereof may be modestly affected by persistent stimulation of CYP1A2 on repeat examinations.

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Short- and long-term reproducibility of radioisotopic examination of gastric emptying

Cited by 16 publications

References 18 publications

How reproducible is cutaneous electrogastrography? An in‐depth evidence‐based study¹

How reproducible is cutaneous electrogastrography? An in‐depth evidence‐based study¹

13C-α-Ketoisocaproic Acid Breath Test Revisited: An In-Depth Reproducibility Study Advocates an Extended Breath Sampling Period

¹³C-methacetin breath test reproducibility study reveals persistent CYP1A2 stimulation on repeat examinations

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Short- and long-term reproducibility of radioisotopic examination of gastric emptying

Cited by 16 publications

References 18 publications

How reproducible is cutaneous electrogastrography? An in‐depth evidence‐based study1

How reproducible is cutaneous electrogastrography? An in‐depth evidence‐based study1

13C-α-Ketoisocaproic Acid Breath Test Revisited: An In-Depth Reproducibility Study Advocates an Extended Breath Sampling Period

13C-methacetin breath test reproducibility study reveals persistent CYP1A2 stimulation on repeat examinations

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How reproducible is cutaneous electrogastrography? An in‐depth evidence‐based study¹

How reproducible is cutaneous electrogastrography? An in‐depth evidence‐based study¹

¹³C-methacetin breath test reproducibility study reveals persistent CYP1A2 stimulation on repeat examinations