Shining light on the paraventricular nucleus: the role of glutamatergic PVN neurons in blood pressure control

Becker, Bryan K.

doi:10.1113/jp277043

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…[ 13 ] The cardiovascular effect of glutamate in several brain areas has been shown, for example, microinjection of L-Glu into the RVLM, PVN, and PAG evoked cardiovascular responses and this effect was attenuated by its NMDA and nonNMDA receptors. [ 5 24 25 ] In line with this evidence, our results indicated that the injection of L-Glu in the PPT increased SBP and MAP and decreased HR. The importance of the cardiovascular effect of the glutamatergic system in the PPT is unclear.…”

Section: Discussionsupporting

confidence: 82%

Effect of the non-N-Methyl-D-aspartate receptor of the glutamatergic system of the pedunculopontine tegmental nucleus on cardiovascular responses in normotensive and hydralazine-induced hypotensive rats

et al. 2022

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Background: Glutamate is an important excitatory neurotransmitter in the pedunculopontine tegmental (PPT) nucleus. The cardiovascular effect of glutamate and its non-N-methyl-D-aspartate (NMDA) receptor in the PPT is unknown; therefore, we evaluated glutamate and its non-NMDA receptor on cardiovascular parameters in normotensive and hypotensive induced by hydralazine (HLZ) in rat. Materials and Methods: After anesthesia, the femoral artery was cannulated for recording of cardiovascular parameters. Microinjection of drugs was done stereotaxically. L-Glutamate (L-Glu) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) (an antagonist of nonNMDA receptor) were microinjected into the PPT in normotensive and HLZ hypotensive rats. Changes (Δ) of mean arterial pressure (MAP), systolic blood pressure (SBP), and heart rate (HR) were obtained and compared with the control group. Results: In normotensive rats, L-Glu significantly increased SBP and MAP ( P < 0.001) and decreased HR ( P < 0.01), whereas CNQX alone did not significantly effect. Coinjection L-Glu + CNQX significantly attenuates the cardiovascular effect of L-Glu ( P < 0.05 to P < 0.01). In hypotension induced by HLZ, SBP and MAP significantly decrease but HR did not change. In HLZ groups, L-Glu significantly improves ( P < 0.05) and CNQX deteriorated hypotension induced by HLZ ( P < 0.05). Coinjection of L-Glu + CNQX also attenuates the effect of L-Glu on Δ MAP and Δ SBP. In hypotension, ΔHR induced by L-Glu was significantly higher than CNQX ( P < 0.01). In L-Glu + CNQX group, ΔHR also was lower than L-Glu ( P < 0.05). Conclusion: Our findings revealed that glutamatergic system of the PPT in both normotensive and hypotension induced by HLZ plays a pressor with bradycardic responses that partly mediated by non-NMDA receptor.

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Section: Discussionsupporting

confidence: 82%

Effect of the non-N-Methyl-D-aspartate receptor of the glutamatergic system of the pedunculopontine tegmental nucleus on cardiovascular responses in normotensive and hydralazine-induced hypotensive rats

et al. 2022

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“…17,57,58 The PVN is one of the major integrative centers in the brain that receives sensory signals from the periphery and regulates sympathetic nervous system outflow and cardiovascular function via the activation of preautonomic neurons that project to the RVLM, NTS, and spinal cord. [59][60][61][62][63] In addition, the, OVLT-a circumventricular organ that lacks a complete blood-brain barrier and is in direct contact with the plasma and cerebrospinal fluid-also projects to the PVN, contributing to blood pressure regulation. [64][65][66] Maternal separation is used as a rodent paradigm of early life stress.…”

Section: Discussionmentioning

confidence: 99%

Epididymal Fat-Derived Sympathoexcitatory Signals Exacerbate Neurogenic Hypertension in Obese Male Mice Exposed to Early Life Stress

et al. 2021

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Previously, we have shown that male mice exposed to maternal separation and early weaning (MSEW)—a mouse model of early life stress—display increased mean arterial pressure compared with controls when fed a high-fat diet. As the stimulation of sensory nerves from fat has been shown to trigger the adipose afferent reflex, we tested whether MSEW male mice show obesity-associated hypertension via the hyperactivation of this sympathoexcitatory mechanism. After 16 weeks on high-fat diet, MSEW mice displayed increased blood pressure, sympathetic activation, and greater depressor response to an α-adrenergic blocker when compared with controls ( P <0.05; n=8), despite no differences in adiposity and plasma leptin. The acute infusion of capsaicin in epididymal white adipose tissue (1.5 pmol/μL of capsaicin, 8 μL/per site, 4 sites, bilaterally) increased the total pressor response in MSEW mice compared with controls (110±19 versus 284±33 mm Hg×30 minutes; P <0.05; n=8). This response was associated with neuronal activation in OVLT, posterior paraventricular nucleus of the hypothalamus, and RVLM ( P <0.05 versus control; n=6–7). Renal denervation abolished both the acute and chronic elevated mean arterial pressure in obese MSEW mice. Moreover, selective sensory denervation of epididymal white adipose tissue using resiniferatoxin (10 pmol/µL solution; n=6) decreased mean arterial pressure in obese MSEW mice only ( P <0.05 versus control). Obese MSEW mice displayed increased epididymal white adipose tissue levels of both tryptophan hydroxylase (Tph1) mRNA expression and its synthesis product serotonin (8.3±1.9 versus 16.6±1.7 ug/mg tissue; P <0.05 versus control). Thus, afferent sensory signals from epididymal white adipose tissue may contribute to the exacerbated fat–brain–blood pressure axis displayed by obese male mice exposed to early life stress.

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Whole-brain monosynaptic inputs and outputs of leptin receptor b neurons of the nucleus tractus solitarii in mice

Sun,

Zhu,

Wang

et al. 2023

Brain Research Bulletin

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Shining light on the paraventricular nucleus: the role of glutamatergic PVN neurons in blood pressure control

Cited by 4 publications

References 5 publications

Effect of the non-N-Methyl-D-aspartate receptor of the glutamatergic system of the pedunculopontine tegmental nucleus on cardiovascular responses in normotensive and hydralazine-induced hypotensive rats

Effect of the non-N-Methyl-D-aspartate receptor of the glutamatergic system of the pedunculopontine tegmental nucleus on cardiovascular responses in normotensive and hydralazine-induced hypotensive rats

Epididymal Fat-Derived Sympathoexcitatory Signals Exacerbate Neurogenic Hypertension in Obese Male Mice Exposed to Early Life Stress

Whole-brain monosynaptic inputs and outputs of leptin receptor b neurons of the nucleus tractus solitarii in mice

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