Shikonins as natural products from traditional Chinese medicinal plants: their biosynthesis, genetic regulation, structuralmodifications, and pharmaceutical functions

Wang, Xuan; Yang, Minkai; Han, Heesup; Wen, Zhongling; Liu, Guihua; Qi, Jinliang; Huang, Lin; Yang, Y.

doi:10.1360/ssv-2021-0152

Cited by 4 publications

(9 citation statements)

References 106 publications

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“…The potential of environmental factors in changing plant constituents merits further study. In previous studies, shikonin and its derivatives were observed to inhibit the growth of tumor cells by activating miR-17-5p/PTEN/Akt, STAT3, PI3K/Akt, ROS, among other pathways 25 . Through network pharmacology, we identi ed the signaling pathways closely related to the anticancer effect of Lithospermum.…”

Section: Discussionmentioning

confidence: 98%

“…Chemical components of Echium were notably associated with its traditional applications and pharmacological effects. Shikonins are often used for their anti-in ammatory, antibacterial, antitumor, wound healing effects and so on 25 . Phenolic acids have certain anticancer properties and are known to promote blood circulation 26 .…”

Section: Discussionmentioning

confidence: 99%

“…This seems to be consistent with the contraceptive effect of Lithospermum. The Arnebia species is often used for a variety of in ammatory conditions, such as arthritis, colitis, and dermatitis and so on 25 . Through network pharmacology, β-santalol, osthol, arnebifuranone in species of Arnebia were identi ed to regulate the NOD-like receptor signaling pathway through MAPK8, XIAP, MAPK14, and TNF targets.…”

Section: Discussionmentioning

confidence: 99%

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Exploring pharmaphylogeny from multiple perspectives: A case study on Lithospermeae

Yan

Wei

Qiu

et al. 2022

Preprint

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Lithospermeae, a tribe under the subfamily Boraginoidae, is a perennial herb containing about 470 species under 26 genera, mainly distributed in temperate and tropical regions. To gain a deeper understanding of the medicinal plants of Lithospermeae and better protect and develop plant medicinal resources, the phytochemistry, pharmacology, and traditional use of Lithospermeae with medicinal value were analyzed. Phylogenetic analysis was carried out based on the internal transcribed spacer (ITS) sequence. Through spatial analysis and the species distribution model, the spatial distribution pattern of Lithospermeae medicinal plants was analyzed. At the same time, the relevant targets and pathways involved in the pharmacological effects of commonly used medicinal plants were predicted using network pharmacology to further explore the genetic origin of Lithospermeae and enrich the pharmaphylogeny of medicinal plants. In this study, the chemical composition, traditional efficacy, modern pharmacological activity, geographical distribution model, molecular phylogeny, and network pharmacology of Lithospermeae were analyzed for the first time. Based on our findings, the pharmaphylogeny of Lithospermeae was preliminarily discussed, providing the scientific basis for basic research regarding Lithospermeae. At the same time, this study explored the relationship between the development of the regional medicinal plant industry and the protection of biodiversity. Furthermore, our findings provide direction and theoretical guidance for the study of the phylogenetic relationships in medicinal plants and the development of Lithospermeae medicinal plant resources.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Exploring pharmaphylogeny from multiple perspectives: A case study on Lithospermeae

Yan

Wei

Qiu

et al. 2022

Preprint

View full text Add to dashboard Cite

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“…Because of their optical activity, shikonin compounds can be divided into two optical isomers: R-shikonin and S-alkannin (Figure 1). Since alkannin is roughly similar to shikonin in terms of distribution, but it has fewer plants than shikonin, most studies have focused on shikonin (Wang et al, 2022). Moreover, shikonin had more significant and extensive anti-tumor activities than alkannin.…”

Section: Chemical Structuresmentioning

confidence: 99%

“…Therefore, we reviewed the effects of shikonin on gynecological malignancies (Figure 2). Estrogen can promote the development of female secondary sexual characteristics, establish and maintain reproductive function, in addition to regulating cell growth, division and differentiation and other physiological processes (Wang et al, 2022). The functions of estrogen are mainly realized through the combination of estrogen receptor (ER) in cells, which includes ERα, ERβ, and G protein coupling with estrogen receptor (GPER).…”

Section: Anti-gynecological Malignant Tumor Effectsmentioning

confidence: 99%

Research Progress on Structure and Anti-Gynecological Malignant Tumor of Shikonin

Kong

et al. 2022

Front. Chem.

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Gynecological malignancy seriously threatens the physical and mental health of women. Shikonin is a naphthoquinone compound with a variety of biological activities. Studies have shown that shikonin can inhibit cell proliferation, promote cell apoptosis and induce cell necrosis. And in recent years, shikonin are also being increasingly used for the study of gynecological malignant diseases. Therefore, we reviewed the mechanism of action and structure optimization of shikonin in gynecological malignant tumors, in order to provide some reference for further research and development of related drug.

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Exploring pharmaphylogeny from multiple perspectives: a case study on Lithospermeae

Yan

Wei

Qiu

et al. 2023

Sci Rep

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Lithospermeae Dumort., a tribe under the subfamily Boraginoidae, is a perennial herb containing approximately 470 species under 26 genera, primarily distributed in temperate and tropical regions. To gain a deeper understanding of the medicinal plants of Lithospermeae and better protect and develop plant medicinal resources, the phytochemistry, pharmacology, and traditional use of Lithospermeae with medicinal value were analyzed. Phylogenetic analysis was carried out based on the internal transcribed spacer sequence. Through spatial analysis and the species distribution model, the spatial distribution pattern of Lithospermeae medicinal plants was analyzed. Meanwhile, the relevant targets and pathways involved in the pharmacological effects of commonly used medicinal plants were predicted using network pharmacology to further explore the genetic origin of Lithospermeae and enrich the pharmaphylogeny of medicinal plants. In this study, the chemical composition, traditional efficacy, and modern pharmacological activity of Lithospermeae were collected for the first time and analyzed in combination with the geographical distribution model, molecular phylogeny, and network pharmacology. Based on our findings, the pharmaphylogeny of Lithospermeae was preliminarily discussed, providing the scientific basis for basic research regarding Lithospermeae. Concurrently, this study explored the relationship between the development of the regional medicinal plant industry and the protection of biodiversity. Furthermore, our findings provide direction and theoretical guidance for the study of the phylogenetic relationships in medicinal plants and the development of Lithospermeae medicinal plant resources.

show abstract

Shikonins as natural products from traditional Chinese medicinal plants: their biosynthesis, genetic regulation, structuralmodifications, and pharmaceutical functions

Cited by 4 publications

References 106 publications

Exploring pharmaphylogeny from multiple perspectives: A case study on Lithospermeae

Exploring pharmaphylogeny from multiple perspectives: A case study on Lithospermeae

Research Progress on Structure and Anti-Gynecological Malignant Tumor of Shikonin

Exploring pharmaphylogeny from multiple perspectives: a case study on Lithospermeae

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