Shigellosis

Russell, Robert G.; DeTolla, Louis J.

doi:10.1007/978-3-642-84924-4_11

Cited by 5 publications

(8 citation statements)

References 27 publications

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“…Microscopically, there are varying degrees of mucosal epithelial necrosis, erosion, ulceration, and hemorrhage (Figure 12). 34,39 The mucosal surface is often covered in a mat of fibrin, cellular debris, mucus, but Shigella bacteria are not commonly visible in the authors’ experience. 34,35,39 The lamina propria is infiltrated by neutrophils and mononuclear cells that occasionally infiltrate the submucosa.…”

Section: Bacterial and Fungal Causes Of Gastrointestinal Tract Lesion...mentioning

confidence: 90%

“…34,39 The mucosal surface is often covered in a mat of fibrin, cellular debris, mucus, but Shigella bacteria are not commonly visible in the authors’ experience. 34,35,39 The lamina propria is infiltrated by neutrophils and mononuclear cells that occasionally infiltrate the submucosa. 34,39 Other findings include crypts filled with neutrophils (crypt abscesses), decreased goblet cells, as well as fibrin thrombi within the blood vessels in the submucosa and serosa.…”

Section: Bacterial and Fungal Causes Of Gastrointestinal Tract Lesion...mentioning

confidence: 90%

“…Grossly, cecal and colonic walls are thick and edematous, and there may be diphtheritic membranes overlying variably hemorrhagic necrotic and ulcerative mucosal surfaces (Figure 11). 34,38 Mesenteric lymph nodes are often enlarged, congested, and edematous. 39 Lesions within the stomach are less common.…”

Section: Bacterial and Fungal Causes Of Gastrointestinal Tract Lesion...mentioning

confidence: 99%

“…34,35,39 The lamina propria is infiltrated by neutrophils and mononuclear cells that occasionally infiltrate the submucosa. 34,39 Other findings include crypts filled with neutrophils (crypt abscesses), decreased goblet cells, as well as fibrin thrombi within the blood vessels in the submucosa and serosa. 34,39 Shigella -specific antibodies have identified intralesional bacteria within superficial and crypt epithelial cells, crypt abscesses, lamina propria, and lymphoid tissue.…”

Section: Bacterial and Fungal Causes Of Gastrointestinal Tract Lesion...mentioning

confidence: 99%

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Common and Not-So-Common Pathologic Findings of the Gastrointestinal Tract of Rhesus and Cynomolgus Macaques

et al. 2022

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Rhesus and cynomolgus macaques are the most frequently used nonhuman primate (NHP) species for biomedical research and toxicology studies of novel therapeutics. In recent years, there has been a shortage of laboratory macaques due to a variety of competing factors. This was most recently exacerbated by the surge in NHP research required to address the severe acute respiratory syndrome (SARS)-coronavirus 2 pandemic. Continued support of these important studies has required the use of more varied cohorts of macaques, including animals with different origins, increased exposure to naturally occurring pathogens, and a wider age range. Diarrhea and diseases of the gastrointestinal tract are the most frequently occurring spontaneous findings in macaques of all origins and ages. The purpose of this review is to alert pathologists and scientists involved in NHP research to these findings and their impact on animal health and study endpoints, which may otherwise confound the interpretation of data generated using macaques.

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Section: Bacterial and Fungal Causes Of Gastrointestinal Tract Lesion...mentioning

confidence: 90%

Section: Bacterial and Fungal Causes Of Gastrointestinal Tract Lesion...mentioning

confidence: 90%

Section: Bacterial and Fungal Causes Of Gastrointestinal Tract Lesion...mentioning

confidence: 99%

Section: Bacterial and Fungal Causes Of Gastrointestinal Tract Lesion...mentioning

confidence: 99%

See 2 more Smart Citations

Common and Not-So-Common Pathologic Findings of the Gastrointestinal Tract of Rhesus and Cynomolgus Macaques

et al. 2022

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“…are among the most common enteric pathogens recovered from captive nonhuman primates, occurring most commonly in Old World Rosenberg et al (1980). Endemic infections within colonies are maintained by asymptomatic carriers (Banish et al, 1993b;Russell and DeTolla, 1993). Shigella flexneri is the most frequent isolate, including serotypes la, 2a, 3, 4, 5, 6, and 15 (Russell and DeTolla, 1993), with S. sonnei and S. boydii occurring less frequently.…”

Section: A Shigellosismentioning

confidence: 99%