Further, alcohol-associated cognitive decline has been extensively studied in other populations, 5-7 and studies have shown that alcohol use is an important factor of cognitive decline in people. Many studies have recorded that the consumption of alcohol by firefighters is higher than that in the general population. 8,9 Therefore, high alcohol use is also an important factor of cognitive decline among firefighters. The brain is a major site that exhibits the neurotoxic effects of alcohol: heavy alcohol consumption induces selective neuronal loss as well as reduction of synaptic complexity in specific regions of the brain. Such alcohol-induced changes may precipitate various neurological dysfunctions such as working memory, attention control, depression, anxiety, and executive functions like response inhibition. 10,11 However, the mechanisms underlying the neurotoxic effects of alcohol on the human brain, and cognitive impairment, are poorly understood. Recently, neuroinflammation gained attention for playing a role in the neurotoxic effect of alcohol. There is growing evi