Shifting Prevalence of Gallbladder Polyps in Korea

Lee, Yoo Jin; Park, Kyung Sik; Cho, Kwang Bum; Kim, Eun Soo; Jang, Byoung Kuk; Chung, Woo Jin; Hwang, Jae Seok

doi:10.3346/jkms.2014.29.9.1247

Cited by 35 publications

(60 citation statements)

References 22 publications

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“…A Korean study in 1999, which evaluated patients who underwent health screening examinations, reported the overall prevalence to be 2.94% (3.63% in men, 2.09% in women) 12. Another Korean study in 2012 reported an 8.5% prevalence 13. In our study, the prevalence rate was 9.96%, which was higher than previously reported in Korea.…”

Section: Discussioncontrasting

confidence: 80%

Prevalence and Risk Factors of Gallbladder Polypoid Lesions in a Healthy Population

et al. 2016

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PurposeTo determine the prevalence of and investigate the risk factors for gallbladder (GB) polypoid lesions in a healthy population.Materials and MethodsA total of 23827 subjects who underwent abdominal ultrasonography in conjunction with health screening examinations were retrospectively analyzed. The prevalence of risk factors for GB polypoid lesions were evaluated. In addition, risk factors according to the number of polypoid lesions and the presence of stones with polypoid lesions were investigated. To analyze these risk factors, a control group was established with a 1:2 ratio matched for age and sex.ResultsThe prevalence of GB polypoid lesions was identified as 9.96%. On multivariate analysis, chronic hepatitis B infection (CHB) and the presence of metabolic syndrome (MS) were risk factors for GB polypoid lesions. CHB and MS were also significant independent risk factors for multiple GB polypoid lesions when compared with solitary GB polypoid lesions. In addition, gastric Helicobacter pylori infection and MS were significant risk factors for GB polypoid lesions with stones when compared with GB polypoid lesions without stones.ConclusionThe prevalence of GB polypoid lesions in a healthy Korean population was 9.96%. Patients with CHB and MS need to be carefully examined for such lesions.

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Section: Discussioncontrasting

confidence: 80%

Prevalence and Risk Factors of Gallbladder Polypoid Lesions in a Healthy Population

et al. 2016

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“…1,[6][7][8] GBPs prevalence is increasing among people who have increased age, male gender, hypertension, diabetes, hepatitis C infection, impaired fasting glycemia and obese. 9 The incidence is either equal or close in both genders. 4,5 Although polypoid lesions are seen in all ages, they are more common in individuals that are over 40 years old.…”

Section: Demographic Findingsmentioning

confidence: 99%

Diagnosis and Treatment of Gallbladder Polyps: Current Perspectives

Dılek

Karasu

Dılek

2019

Euroasian Journal of Hepato-Gastroenterology

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Introduction: Gallbladder polyps (GBPs) are generally harmless, but the planning of diagnosis and treatment of the GBP is of clinical importance due to the high mortality risk of delays in the diagnosis of gallbladder carcinomas that show polypoid development. Materials and methods: GBPs are usually incidentally detected during ultrasonographic (USG) examinations of the abdomen. The risk of carcinoma development from polypoid lesions in the literature is reported as 0-27%. There is no consensus about the management of the GBPs. Herein, we reviewed the contemporary data to update our knowledge about diagnosis and treatment of gallbladder polyps. Results: Polyps can be identified in five different groups, primarily as neoplastic and non-neoplastic. Cholesterol polyps account for 60% of all cases. The most common (25%) benign polypoid lesions after cholesterol polyps are adenomyomas. Conclusion: Ultrasonography and endoscopic ultrasonography seems to be the most important tool in differential diagnosis and treatment. Ultrasonography should be repeated in every 3-12 months in cases that are thought to be risky. Nowadays, the most common treatment approach is to perform cholecystectomy in patients with polyps larger than 10 mm in diameter. Radical cholecystectomy and/or segmental liver resections should be planned in cases of malignancy.

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“…We also found that the frequency of gallbladder polyps in patients aged ≥50 yr was lower than that in patients aged <50 yr (7.4% vs. 8.3%). This finding was not unexpected because a large Korean study showed a peak in the prevalence of gallbladder polyps in males 30-39 yr of age and in females 40-49 yr age ( 27 ). In addition, CRNs were significantly more prevalent in patients with than in those without gallbladder polyps in the age ≥50 yr group (47.0% vs. 38.1%) but not in the age <50 yr group.…”

Section: Discussionmentioning

confidence: 73%

“…Two case-control studies from Korea suggested that metabolic syndrome contributes to the development of gallbladder polyps ( 14 26 ). In another large Korean study, in which 14,250 individuals were evaluated, a possible influence of obesity and hyperlipidemia on the risk of developing gallbladder polyps was determined ( 27 ). A previous study from Japan also reported that patients with gallbladder polyps were more obese than patients in the control group ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

The Risk of Colorectal Neoplasia in Patients with Gallbladder Diseases

2015

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Cholecystectomy is associated with an increased risk of colorectal cancer, but little is known about the relationship between gallbladder disease and colorectal adenoma. Gallbladder polyps and colorectal neoplasia (CRN) share several risk factors such as obesity, diabetes and metabolic syndrome, which might account for their association. In this study, we investigated whether asymptomatic patients with gallbladder disease are at increased risk of CRN and identified the factors to their association. The study population consisted of 4,626 consecutive, asymptomatic individuals drawn from a prospective health check-up cohort who underwent both ultrasonography and colonoscopy screening. The prevalence of CRNs in patients with gallbladder polyps or gallstones was significantly higher than that in the control group (32.1% vs. 26.8%; P = 0.032, 35.8% vs. 26.9%; P = 0.020). A multivariate regression analysis showed that gallbladder polyps were an independent risk factor for CRN [adjusted odds ratio (OR): 1.29; 95% confidence interval (CI); 1.03-1.62] whereas gallstones were not (adjusted OR: 1.14; 95% CI: 0.79-1.63). The adjusted OR for the risk of CRN was 1.12 for gallbladder polyps < 5 mm (95% CI, 0.85-1.46) and 1.79 for gallbladder polyps ≥ 5 mm (95% CI, 1.15-2.77). The prevalence of CRN increased with increasing polyp size (P trend = 0.022). Our results suggest that colorectal neoplasia is significantly related to gallbladder polyps, especially those ≥ 5 mm.Graphical Abstract

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Shifting Prevalence of Gallbladder Polyps in Korea

Cited by 35 publications

References 22 publications

Prevalence and Risk Factors of Gallbladder Polypoid Lesions in a Healthy Population

Prevalence and Risk Factors of Gallbladder Polypoid Lesions in a Healthy Population

Diagnosis and Treatment of Gallbladder Polyps: Current Perspectives

The Risk of Colorectal Neoplasia in Patients with Gallbladder Diseases

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