Shh goes multidirectional in axon guidance

Bovolenta, Paola; Sánchez-Arrones, Luisa

doi:10.1038/cr.2011.187

Cited by 3 publications

(2 citation statements)

References 17 publications

(28 reference statements)

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“…It will be interesting to determine whether Dhh is also involved in redox homeostasis and whether Dhh and Shh are commutable in SCs for ensuring nerve maintenance and regeneration. The involvement of Shh in the control of nerve growth has been known for a decade (reviewed in Bovolenta and Sanchez-Arrones 5 and Yam and Charron 57 ) and its role in neuroprotection via its secretion by SCs has also been documented ( 22 ). The importance of SCs for nerve regeneration is also well known (reviewed in Glenn and Talbot 17 and Jessen et al 23 ), as is the fact that SCs are sensitive to the redox environment ( 30 , 45 , 48 ).…”

Section: Discussionmentioning

confidence: 99%

Nerves Control Redox Levels in Mature Tissues Through Schwann Cells and Hedgehog Signaling

Meda

Gauron

Rampon

et al. 2016

Antioxidants & Redox Signaling

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Aims: Recent advances in redox biology have emphasized the role of hydrogen peroxide (H2O2) in the modulation of signaling pathways and revealed that H2O2 plays a role in cellular remodeling in adults. Thus, an understanding of the mechanisms that control H2O2 levels in mature tissue would be of great interest. Results: We used a denervation strategy to demonstrate that sensory neurons are responsible for controlling H2O2 levels under normal conditions and after being lesioned. Moreover, we demonstrate that severed nerves respond to appendage amputation via the induction of Hedgehog signaling and that this signaling is responsible for H2O2 production in the wounded epidermis. Finally, we show that H2O2 and nerve growth are regulated via reciprocal action in adults. Innovation and Conclusion: These data support a new paradigm for the regulation of tissue homeostasis: H2O2 attracts nerves and nerves control H2O2 levels in a positive feedback loop. This finding suggests that the peripheral nerve redox environment could be a target for manipulating cell plasticity in adults. Antioxid. Redox Signal. 24, 299–311.

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Section: Discussionmentioning

confidence: 99%

Nerves Control Redox Levels in Mature Tissues Through Schwann Cells and Hedgehog Signaling

Meda

Gauron

Rampon

et al. 2016

Antioxidants & Redox Signaling

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“…Therefore, in the spinal cord, both sources of netrin‐1 cooperate to guide commissural neuron at the midline. Other secreted proteins such as VEGF (Ruiz de Almodovar et al ) and Shh (Charron et al ; Bovolenta and Sanchez‐Arrones ; Sloan et al ; Wu et al ) are expressed at the floor plate and act redundantly with netrin‐1 to attract axons as they get close to the FP.…”

Section: The Developing Nervous Systemmentioning

confidence: 99%

Construction and reconstruction of brain circuits: normal and pathological axon guidance

Roig‐Puiggros

Vigouroux

Beckman

et al. 2019

Journal of Neurochemistry

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Perception of our environment entirely depends on the close interaction between the central and peripheral nervous system. In order to communicate each other, both systems must develop in parallel and in coordination. During development, axonal projections from the CNS as well as the PNS must extend over large distances to reach their appropriate target cells. To do so, they read and follow a series of axon guidance molecules. Interestingly, while these molecules play critical roles in guiding developing axons, they have also been shown to be critical in other major neurodevelopmental processes, such as the migration of cortical progenitors. Currently, a major hurdle for brain repair after injury or neurodegeneration is the absence of axonal regeneration in the mammalian CNS. By contrasts, PNS axons can regenerate. Many hypotheses have been put forward to explain this paradox but recent studies suggest that hacking neurodevelopmental mechanisms may be the key to promote CNS regeneration. Here we provide a seminar report written by trainees attending the second Flagship school held in Alpbach, Austria in September 2018 organized by the International Society for Neurochemistry (ISN) together with the Journal of Neurochemistry (JCN). This advanced school has brought together leaders in the fields of neurodevelopment and regeneration in order to discuss major keystones and future challenges in these respective fields.

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Direction of commissural axon projections in different regions of the spinal cord during chicken embryonic development

Yang

Yusoff

et al. 2017

Neuroscience

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Shh goes multidirectional in axon guidance

Cited by 3 publications

References 17 publications

Nerves Control Redox Levels in Mature Tissues Through Schwann Cells and Hedgehog Signaling

Nerves Control Redox Levels in Mature Tissues Through Schwann Cells and Hedgehog Signaling

Construction and reconstruction of brain circuits: normal and pathological axon guidance

Direction of commissural axon projections in different regions of the spinal cord during chicken embryonic development

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