Direction of commissural axon projections in different regions of the spinal cord during chicken embryonic development

Li, Han; Yang, Ciqing; Yusoff, Narazah Mohd; Yahaya, Badrul Hisham; Lin, Juntang

doi:10.1016/j.neuroscience.2017.06.053

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…16 Most spinal interneurons, including ipsilateral inhibitory neurons, project axons spanning several segments along the R-C axis. [17][18][19][20][21] Here, taking advantage of the transparency and accessibility of the intact spinal cord in larval zebrafish, as well as its significant homology with other vertebrates, we mapped connectivity along the R-C axis in a major ipsilateral inhibitory population: V1 neurons.…”

Section: Introductionmentioning

confidence: 99%

Spinal V1 neurons inhibit motor targets locally and sensory targets distally

Sengupta¹,

Daliparthi²,

Roussel³

et al. 2021

Current Biology

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Section: Introductionmentioning

confidence: 99%

Spinal V1 neurons inhibit motor targets locally and sensory targets distally

Sengupta¹,

Daliparthi²,

Roussel³

et al. 2021

Current Biology

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“…Furthermore, species differences make it challenging to directly administer current antibodies and viral vectors to birds' retinas or central nervous systems. Nevertheless, studying retinal ganglion cell subtypes in chicks may be more effectively accomplished using in vivo transfection or electroporation transfection [93][94][95] . For nonmammalian vertebrates, the pineal gland of birds and teleost fish has rhythmic pacing functions and is involved in constituting the multi-oscillatory circadian timing system 96,97 .…”

Section: Photosensitive Regulation Of Circadian Rhythms By Opn4mentioning

confidence: 99%

Melanopsin-mediated optical entrainment regulates circadian rhythms in vertebrates

Pan,

Wang,

Chen

et al. 2023

Commun Biol

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Melanopsin (OPN4) is a light-sensitive protein that plays a vital role in the regulation of circadian rhythms and other nonvisual functions. Current research on OPN4 has focused on mammals; more evidence is needed from non-mammalian vertebrates to fully assess the significance of the non-visual photosensitization of OPN4 for circadian rhythm regulation. There are species differences in the regulatory mechanisms of OPN4 for vertebrate circadian rhythms, which may be due to the differences in the cutting variants, tissue localization, and photosensitive activation pathway of OPN4. We here summarize the distribution of OPN4 in mammals, birds, and teleost fish, and the classical excitation mode for the non-visual photosensitive function of OPN4 in mammals is discussed. In addition, the role of OPN4-expressing cells in regulating circadian rhythm in different vertebrates is highlighted, and the potential rhythmic regulatory effects of various neuropeptides or neurotransmitters expressed in mammalian OPN4-expressing ganglion cells are summarized among them.

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“…Interestingly, blockade of glycinergic neurons disrupts R-C coordination independently of left-right alternation, implying that ipsilateral inhibition is vital for locomotor propagation 15 . Most spinal interneurons, including ipsilateral inhibitory neurons, project axons spanning several segments along the R-C axis [16][17][18][19][20] yet not much is known about their connectivity in this axis or its functional implications. Here, taking advantage of the transparency and accessibility of the intact spinal cord in larval zebrafish, as well as its significant homology with other vertebrates, we mapped connectivity along the R-C axis in a major ipsilateral inhibitory population: V1 neurons.…”

Section: Introductionmentioning

confidence: 99%

Spinal V1 neurons inhibit motor targets locally and sensory targets distally to coordinate locomotion

Sengupta

Daliparthi

Roussel

et al. 2021

Preprint

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Rostro-caudal coordination of spinal motor output is essential for locomotion. Most spinal interneurons project axons longitudinally to govern locomotor output, yet their connectivity along this axis remains unclear. In this study, we use larval zebrafish to map synaptic outputs of a major inhibitory population, V1 (Eng1+) neurons, which are implicated in dual sensory and motor functions. We find that V1 neurons exhibit long axons extending rostrally and exclusively ipsilaterally for an average of 6 spinal segments; however, they do not connect uniformly with their post-synaptic targets along the entire length of their axon. Locally, V1 neurons inhibit motor neurons (both fast and slow) and other premotor targets including V2a, V2b and commissural pre-motor neurons. In contrast, V1 neurons make robust inhibitory contacts throughout the rostral extent of their axonal projections onto a dorsal horn sensory population, the Commissural Primary Ascending neurons (CoPAs). In a computational model of the ipsilateral spinal network, we show that this pattern of short range V1 inhibition to motor and premotor neurons is crucial for coordinated rostro-caudal propagation of the locomotor wave. We conclude that spinal network architecture in the longitudinal axis can vary dramatically, with differentially targeted local and distal connections, yielding important consequences for function.

show abstract

Direction of commissural axon projections in different regions of the spinal cord during chicken embryonic development

Cited by 3 publications

References 27 publications

Spinal V1 neurons inhibit motor targets locally and sensory targets distally

Spinal V1 neurons inhibit motor targets locally and sensory targets distally

Melanopsin-mediated optical entrainment regulates circadian rhythms in vertebrates

Spinal V1 neurons inhibit motor targets locally and sensory targets distally to coordinate locomotion

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