Shenqi compound ameliorates type-2 diabetes mellitus by modulating the gut microbiota and metabolites

Wang, Heting; Xie, Chunguang; Huc, Zhipeng; Zhang, Yuan; Peng, Sihan; He, Yuchi; Kang, Jian; Gao, Hong; Yuan, Haipo; Liu, Ya; Fan, Gang

doi:10.1016/j.jchromb.2022.123189

Cited by 22 publications

(13 citation statements)

References 49 publications

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“…After SQC intervention, the ratio of Bacteroidetes to Firmicutes could be improved in the gut. Moreover, SQC improves glycolysis, gluconeogenesis, the citrate cycle, lipid metabolism, amino acid metabolism, and SCFA metabolism by regulating the relative abundance of Blautia, Prevotellaceae, Rothia, Roseburia, Lactobacillus , Butyricimonas , and Bacteroides ( 62 ).…”

Section: Effects Of Prepared Chinese Medicine On Intestinal Microbiot...mentioning

confidence: 99%

Review of the correlation between Chinese medicine and intestinal microbiota on the efficacy of diabetes mellitus

Min

Tang

et al. 2023

Front. Endocrinol.

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Diabetes mellitus is a serious metabolic disorder that can lead to a number of life-threatening complications. Studies have shown that intestinal microbiota is closely related to the development of diabetes, making it a potential target for the treatment of diabetes. In recent years, research on the active ingredients of traditional Chinese medicine (TCM), TCM compounds, and prepared Chinese medicines to regulate intestinal microbiota and improve the symptoms of diabetes mellitus is very extensive. We focus on the research progress of TCM active ingredients, herbal compounds, and prepared Chinese medicines in the treatment of diabetes mellitus in this paper. When diabetes occurs, changes in the abundance and function of the intestinal microbiota disrupt the intestinal environment by disrupting the intestinal barrier and fermentation. TCM and its components can increase the abundance of beneficial bacteria while decreasing the abundance of harmful bacteria, regulate the concentration of microbial metabolites, improve insulin sensitivity, regulate lipid metabolism and blood glucose, and reduce inflammation. TCM can be converted into active substances with pharmacological effects by intestinal microbiota, and these active substances can reverse intestinal microecological disorders and improve diabetes symptoms. This can be used as a reference for diabetes prevention and treatment.

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Section: Effects Of Prepared Chinese Medicine On Intestinal Microbiot...mentioning

confidence: 99%

Review of the correlation between Chinese medicine and intestinal microbiota on the efficacy of diabetes mellitus

Min

Tang

et al. 2023

Front. Endocrinol.

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“…Blautia bacteria possess potential probiotic properties that help regulate host health and alleviate metabolic syndrome (Liu et al, 2021). It was reported that the Shenqi compound could increase the abundance of Blautia bacteria and its metabolites in model rats and thereby improve T2DM (Zhang et al, 2022b). Furthermore, Escherichia-Shigella bacteria are a class of opportunistic pathogens associated with inflammation.…”

Section: Regulation Of the Gut Microbiota Compositionmentioning

confidence: 99%

The interplay between herbal medicines and gut microbiota in metabolic diseases

et al. 2023

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Globally, metabolic diseases are becoming a major public health problem. Herbal medicines are medicinal materials or preparations derived from plants and are widely used in the treatment of metabolic diseases due to their good curative effects and minimal side effects. Recent studies have shown that gut microbiota plays an important role in the herbal treatment of metabolic diseases. However, the mechanisms involved are still not fully understood. This review provides a timely and comprehensive summary of the interactions between herbal medicines and gut microbiota in metabolic diseases. Mechanisms by which herbal medicines treat metabolic diseases include their effects on the gut microbial composition, the intestinal barrier, inflammation, and microbial metabolites (e.g., short-chain fatty acids and bile acids). Herbal medicines can increase the abundance of beneficial bacteria (e.g., Akkermansia and Blautia), reduce the abundance of harmful bacteria (e.g., Escherichia–Shigella), protect the intestinal barrier, and alleviate inflammation. In turn, gut microbes can metabolize herbal compounds and thereby increase their bioavailability and bioactivity, in addition to reducing their toxicity. These findings suggest that the therapeutic effects of herbal medicines on metabolic diseases are closely related to their interactions with the gut microbiota. In addition, some methods, and techniques for studying the bidirectional interaction between herbal medicines and gut microbiota are proposed and discussed. The information presented in this review will help with a better understanding of the therapeutic mechanisms of herbal medicines and the key role of gut microbiota.

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“…A number of studies in animal models of T2DM have extensively explored the interactions between TCMs and gut microbiota ( 100 – 107 ). Zhou et al.…”

Section: Pharmacomicrobiomics Focuses On T2dmmentioning

confidence: 99%

Pharmacomicrobiomics and type 2 diabetes mellitus: A novel perspective towards possible treatment

Huang

Sun²,

Shang

et al. 2023

Front. Endocrinol.

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Type 2 diabetes mellitus (T2DM), a major driver of mortality worldwide, is more likely to develop other cardiometabolic risk factors, ultimately leading to diabetes-related mortality. Although a set of measures including lifestyle intervention and antidiabetic drugs have been proposed to manage T2DM, problems associated with potential side-effects and drug resistance are still unresolved. Pharmacomicrobiomics is an emerging field that investigates the interactions between the gut microbiome and drug response variability or drug toxicity. In recent years, increasing evidence supports that the gut microbiome, as the second genome, can serve as an attractive target for improving drug efficacy and safety by manipulating its composition. In this review, we outline the different composition of gut microbiome in T2DM and highlight how these microbiomes actually play a vital role in its development. Furthermore, we also investigate current state-of-the-art knowledge on pharmacomicrobiomics and microbiome’s role in modulating the response to antidiabetic drugs, as well as provide innovative potential personalized treatments, including approaches for predicting response to treatment and for modulating the microbiome to improve drug efficacy or reduce drug toxicity.

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Shenqi compound ameliorates type-2 diabetes mellitus by modulating the gut microbiota and metabolites

Cited by 22 publications

References 49 publications

Review of the correlation between Chinese medicine and intestinal microbiota on the efficacy of diabetes mellitus

Review of the correlation between Chinese medicine and intestinal microbiota on the efficacy of diabetes mellitus

The interplay between herbal medicines and gut microbiota in metabolic diseases

Pharmacomicrobiomics and type 2 diabetes mellitus: A novel perspective towards possible treatment

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