Shenmai Injection Attenuates Myocardial Ischemia/Reperfusion Injury by Targeting Nrf2/GPX4 Signalling-Mediated Ferroptosis

Mei, Shenglan; Xia, Zhongyuan; Qiu, Zhen; Jia, Yifan; Zhou, Jinjian; Zhou, Bin

doi:10.1007/s11655-022-3620-x

Cited by 23 publications

(9 citation statements)

References 32 publications

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“…Disturbed GSH metabolism in cardiomyocytes is also detected in post-MI hearts [49]. Certain clinical drugs, including dexmedetomidine, Shenmai injection, and Naringenin, have been approved for attenuating cardiac I/R by targeting ferroptotic mechanisms, indicating ferroptosis may be a promising strategy for treating CVD [50][51][52].…”

Section: Ferroptosis and Cardiomyopathymentioning

confidence: 99%

A Panoramic View of Ferroptosis in Cardiovascular Disease

Cheng¹,

Yu²,

Yang³

et al. 2023

Kidney Dis

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Background: Cardiovascular disease (CVD) remains the leading cause of disease burden worldwide. Ferroptosis, an iron-dependent form of programmed cell death, is characterized by the lethal accumulation of lipid peroxidation, which is morphologically, biochemically and genetically distinct from apoptosis, necrosis and pyroptosis. Emerging evidence provides exciting novel insights to allow for a deeper understanding of the physiology and pathology of ferroptosis in CVD. Summary: The rapidly evolving insights into ferroptosis have revealed its role in the pathogenesis of diverse forms of CVD, including cardiomyopathy, heart failure, atherosclerosis, pulmonary arterial hypertension and cerebrovascular disease. Various types of metabolic pathways are involved in the regulation of ferroptosis, including iron metabolism, lipid metabolism and oxidative metabolism. Modulators of ferroptosis, such as several clinical drugs, preclinical compounds and other emerging materials, have been applied as promising approaches in the prevention and treatment of CVD. Key message: In this review, we provide a 360-degree view of the latest progress in the field of ferroptosis in CVD, highlight the pathogenic role of ferroptosis in CVD and also discuss the importance and future directions of targeting ferroptosis in CVD.

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Section: Ferroptosis and Cardiomyopathymentioning

confidence: 99%

A Panoramic View of Ferroptosis in Cardiovascular Disease

Cheng¹,

Yu²,

Yang³

et al. 2023

Kidney Dis

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“…Ilexsaponin A has powerful antioxidant effects, restores mitochondrial function, inhibits myocardial cell apoptosis, and protects cardiac function ( Zhang et al, 2017 ). Shenmai injection alleviates myocardial ischemia-reperfusion through Nrf2/GPX4 signaling pathway-mediated ferroptosis ( Mei et al, 2022 ). Iron accumulation leads to neuronal damage during blood reperfusion, resulting in ischemic stroke in clinical and animal models, and iron chelators reduce ischemic events in animal models of reperfusion injury.…”

Section: Ferroptosis In Cardiovascular Diseasesmentioning

confidence: 99%

Mechanism of ferroptosis in traditional chinese medicine for clinical treatment: A review

Liu

Jiang²,

He³

et al. 2023

Front. Pharmacol.

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Ferroptosis is an iron-dependent regulation of cell death driven by lipid peroxidation, which is intracellularly dependent on iron and independent of other metals, and morphologically, biochemically, and genetically distinct from apoptosis, necrosis, and autophagy. Ferroptosis is closely related to physiological and pathological processes, such as development, aging, and immunity, and it plays an important role in a variety of diseases. In many departments, traditional Chinese medicine plays an increasingly important role in their clinical treatment. In recent years, an increasing number of studies have been conducted on the mechanism of ferroptosis in traditional Chinese medicine. However, the role of ferroptosis in the clinical treatment of traditional Chinese medicine requires further exploration. This article mainly introduces the application of ferroptosis in studies of the mechanism of traditional Chinese medicine to help clinicians understand the current status of traditional Chinese medicine therapy for the treatment of ferroptosis-related diseases.

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“…Britanin can alleviate ferroptosis by activating AMPK/GSK3β/NRF2 signaling pathway and up-regulating GPX4 [ 207 ]. Naringenin [ 23 ] and Shenmai injection [ 208 ] can inhibit iron ptosis by regulating NRF2/System XC-/GPX4 axis. 6-Gingerol [ 209 ] and curcumin [ 210 ] can alleviate myocardial injury in DC mice and cell models and activate the NRF2/HO-1 pathway by enhancing GPX4 expression.…”

Section: Targeted Interventions and Prospectsmentioning

confidence: 99%

Iron accumulation and lipid peroxidation: implication of ferroptosis in diabetic cardiomyopathy

Yan

Xie

Liu

et al. 2023

Diabetol Metab Syndr

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Diabetic cardiomyopathy (DC) is a serious heart disease caused by diabetes. It is unrelated to hypertension and coronary artery disease and can lead to heart insufficiency, heart failure and even death. Currently, the pathogenesis of DC is unclear, and clinical intervention is mainly symptomatic therapy and lacks effective intervention objectives. Iron overdose mediated cell death, also known as ferroptosis, is widely present in the physiological and pathological processes of diabetes and DC. Iron is a key trace element in the human body, regulating the metabolism of glucose and lipids, oxidative stress and inflammation, and other biological processes. Excessive iron accumulation can lead to the imbalance of the antioxidant system in DC and activate and aggravate pathological processes such as excessive autophagy and mitochondrial dysfunction, resulting in a chain reaction and accelerating myocardial and microvascular damage. In-depth understanding of the regulating mechanisms of iron metabolism and ferroptosis in cardiovascular vessels can help improve DC management. Therefore, in this review, we summarize the relationship between ferroptosis and the pathogenesis of DC, as well as potential intervention targets, and discuss and analyze the limitations and future development prospects of these targets.

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Shenmai Injection Attenuates Myocardial Ischemia/Reperfusion Injury by Targeting Nrf2/GPX4 Signalling-Mediated Ferroptosis

Cited by 23 publications

References 32 publications

A Panoramic View of Ferroptosis in Cardiovascular Disease

A Panoramic View of Ferroptosis in Cardiovascular Disease

Mechanism of ferroptosis in traditional chinese medicine for clinical treatment: A review

Iron accumulation and lipid peroxidation: implication of ferroptosis in diabetic cardiomyopathy

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