Shedding light on hematopoietic stem cells: formation, regulation, and utilization

Robin, Catherine; Lacaud, Georges; Jaffredo, Thierry

doi:10.1002/1873-3468.12481

Cited by 1 publication

(1 citation statement)

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“…However, when this research reached an impasse, the “stem cell theory” was once again proposed. Although many people have questioned it, research on stem cells has still entered people's vision [ 3 ]. After more than 20 years of research, the world's first bone marrow (BM) transplantation operation was successfully completed in 1968, in Washington, D.C., USA.…”

Section: Introductionmentioning

confidence: 99%

Functions and regulatory mechanisms of resting hematopoietic stem cells: a promising targeted therapeutic strategy

Tang

Wang

et al. 2023

Stem Cell Res Ther

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Hematopoietic stem cells (HSCs) are the common and essential precursors of all blood cells, including immune cells, and they are responsible for the lifelong maintenance and damage repair of blood tissue homeostasis. The vast majority (> 95%) of HSCs are in a resting state under physiological conditions and are only activated to play a functional role under stress conditions. This resting state affects their long-term survival and is also closely related to the lifelong maintenance of hematopoietic function; however, abnormal changes may also be an important factor leading to the decline of immune function in the body and the occurrence of diseases in various systems. While the importance of resting HSCs has attracted increasing research attention, our current understanding of this topic remains insufficient, and the direction of clinical targeted treatments is unclear. Here, we describe the functions of HSCs, analyze the regulatory mechanisms that affect their resting state, and discuss the relationship between resting HSCs and different diseases, with a view to providing guidance for the future clinical implementation of related targeted treatments.

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Section: Introductionmentioning

confidence: 99%