Shear-thinning hydrogels containing reactive oxygen species-responsive nanoparticles for salvianolic acid B delivery to rescue oxidative damaged HUVECs

Chen, Hsin-Ho; Yu, Ning; Cheng, Yi-Hsien

doi:10.1016/j.eurpolymj.2021.110982

Cited by 4 publications

(2 citation statements)

References 51 publications

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“…Cross-sectional and longitudinal imaging after elution reveals hollow lumens. Previous literature has indicated that boronic acid and boronate possess ROS-responsive functional groups [57,58], and polymeric nanoparticles with boronate esters respond to ROS through hydrolysis to deliver drugs for EC rescue [59]. In our study, the rapid reaction of glucose and boronate bonds in the PS2 sacrificial hydrogel leads to swift dissolution, further expedited through initial ROS generation by embedded ECs (removed ∼65 min).…”

Section: Discussionmentioning

confidence: 63%

3D-bioprintable endothelial cell-laden sacrificial ink for fabrication of microvessel networks

Cheng,

Theato,

Hsu

2023

Biofabrication

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Although various research efforts have been made to produce a vascular-like network structure as scaffolds for tissue engineering, there are still several limitations. Meanwhile, no articles have been published on the direct embedding of cells within a glucose sensitive sacrificial hydrogel followed by three-dimensional (3D) bioprinting to fabricate vascular structures. In this study, the hydrogel composed of reversibly crosslinked poly(ethylene glycol) diacrylate and dithiothreitol with borax and branched polyethylenimine was used as the sacrificial hydrogel to fabricate vascular-like network structure. The component proportion ratio of the sacrificial hydrogel was optimized to achieve proper self-healing, injectable, glucose-sensitive, and 3D printing properties through the balance of boronate ester bond, hydrogen bond, and steric hinderance effect. The endothelial cells (ECs) can be directly embedded into sacrificial hydrogel and then bioprinted through a 110 m nozzle into the neural stem cell (NSC)-laden non-sacrificial hydrogel, forming the customized EC-laden vascularized microchannel (one-step). The EC-laden sacrificial hydrogel was dissolved immediately in the medium while cells kept growing. The ECs proliferated well within the vascularized microchannel structure and were able to migrate to the non-sacrificial hydrogel in one day. ECs and NSCs interacted around the vascularized microchannel to form capillary-like structure and vascular-like structure expressing CD31 in 14 days. The sacrificial hydrogel conveniently prepared from commercially available chemicals through simple mixing can be used in 3D bioprinting to create customized and complex but easily removable vascularized structure for tissue engineering applications.

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Section: Discussionmentioning

confidence: 63%

3D-bioprintable endothelial cell-laden sacrificial ink for fabrication of microvessel networks

Cheng,

Theato,

Hsu

2023

Biofabrication

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“…Laponite is a kind of nanoclay that is produced in a lab and has found widespread use in the medical field [ 73 ]. As a carrier for SAB distribution, laponite hydrogels incorporating ROS-responsive dextran-based NPs were produced for the study and used as a part of the research [ 45 ]. Under conditions of oxidative stress, the boronic ester modified dextran NP had a spherical shape and had a diameter of 195.3 nm.…”

Section: Peripheral Vascular Disease (Pvd)mentioning

confidence: 99%

Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process

et al. 2022

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Angiogenesis is a vital biological process involving blood vessels forming from pre-existing vascular systems. This process contributes to various physiological activities, including embryonic development, hair growth, ovulation, menstruation, and the repair and regeneration of damaged tissue. On the other hand, it is essential in treating a wide range of pathological diseases, such as cardiovascular and ischemic diseases, rheumatoid arthritis, malignancies, ophthalmic and retinal diseases, and other chronic conditions. These diseases and disorders are frequently treated by regulating angiogenesis by utilizing a variety of pro-angiogenic or anti-angiogenic agents or molecules by stimulating or suppressing this complicated process, respectively. Nevertheless, many traditional angiogenic therapy techniques suffer from a lack of ability to achieve the intended therapeutic impact because of various constraints. These disadvantages include limited bioavailability, drug resistance, fast elimination, increased price, nonspecificity, and adverse effects. As a result, it is an excellent time for developing various pro- and anti-angiogenic substances that might circumvent the abovementioned restrictions, followed by their efficient use in treating disorders associated with angiogenesis. In recent years, significant progress has been made in different fields of medicine and biology, including therapeutic angiogenesis. Around the world, a multitude of research groups investigated several inorganic or organic nanoparticles (NPs) that had the potential to effectively modify the angiogenesis processes by either enhancing or suppressing the process. Many studies into the processes behind NP-mediated angiogenesis are well described. In this article, we also cover the application of NPs to encourage tissue vascularization as well as their angiogenic and anti-angiogenic effects in the treatment of several disorders, including bone regeneration, peripheral vascular disease, diabetic retinopathy, ischemic stroke, rheumatoid arthritis, post-ischemic cardiovascular injury, age-related macular degeneration, diabetic retinopathy, gene delivery-based angiogenic therapy, protein delivery-based angiogenic therapy, stem cell angiogenic therapy, and diabetic retinopathy, cancer that may benefit from the behavior of the nanostructures in the vascular system throughout the body. In addition, the accompanying difficulties and potential future applications of NPs in treating angiogenesis-related diseases and antiangiogenic therapies are discussed.

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Development of injectable hydrogels based on human amniotic membrane and polyethyleneglycol-modified nanosilicates for tissue engineering applications

Kafili

Tamjid

Niknejad

et al. 2022

European Polymer Journal

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Shear-thinning hydrogels containing reactive oxygen species-responsive nanoparticles for salvianolic acid B delivery to rescue oxidative damaged HUVECs

Cited by 4 publications

References 51 publications

3D-bioprintable endothelial cell-laden sacrificial ink for fabrication of microvessel networks

3D-bioprintable endothelial cell-laden sacrificial ink for fabrication of microvessel networks

Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process

Development of injectable hydrogels based on human amniotic membrane and polyethyleneglycol-modified nanosilicates for tissue engineering applications

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