Shear as a Mechanism for Sonically Induced Biological Effects

Rooney, James A.

doi:10.1121/1.1913306

Cited by 106 publications

(54 citation statements)

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“…Ultrasonic cleaning, intensification of heat and mass exchange, stimulation of chemical reactions, haemolysis, sonothrombolysis and sonoporation are examples. The history of these applications from the 1950s up to the present can be traced through papers by Kolb & Nyborg (1956), Elder (1959), Nyborg (1965Nyborg ( , 1978, Rooney (1970Rooney ( , 1972, Lighthill (1978), Liu et al (2002), Wu (2002), Tho, Manasseh & Ooi (2007), Wu & Nyborg (2008), Collis et al (2010) and Wang, Jalikop & Hilgenfeldt (2012). Theoretical studies on bubble-induced microstreaming were performed by Nyborg (1958), Davidson & Riley (1971), Wu & Du (1997), Longuet-Higgins (1998), Maksimov (2007), Liu & Wu (2009) and Doinikov & Bouakaz (2010a,b, 2014.…”

Section: Introductionmentioning

confidence: 98%

Microstreaming generated by two acoustically induced gas bubbles

Doinikov

Bouakaz

2016

J. Fluid Mech.

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A theory is developed that describes microstreaming generated by two interacting gas bubbles in an acoustic field. The theory is used in numerical simulations to compare the characteristics of acoustic microstreaming at different frequencies, separation distances between the bubbles and bubble sizes. It is shown that the interaction of the bubbles leads to a considerable increase in the intensity of the velocity and stress fields of acoustic microstreaming if the bubbles are driven near the resonance frequencies that they have in the presence of each other. Patterns of streamlines for different situations are presented.

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Section: Introductionmentioning

confidence: 98%

Microstreaming generated by two acoustically induced gas bubbles

Doinikov

Bouakaz

2016

J. Fluid Mech.

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“…Due to these limitations on [80]. The created shear stress can also affect the tissues by disrupting cells [52,81]. The second phenomenon is the violent stress inflicted on cells and tissues as a result of inertial cavitation events (collapsing bubbles), such as cell membrane permeabilization (sonoporation) and capillary rupture [82].…”

Section: Safety and Tolerabilitymentioning

confidence: 99%

Ultrasound-mediated ocular delivery of therapeutic agents: a review

Lafond

Aptel

Mestas

et al. 2016

Expert Opinion on Drug Delivery

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Introduction: Due to numerous anatomical and physiological barriers, ocular drug delivery remains a major limitation in the treatment of diseases such as glaucoma, macular degeneration or inflammatory diseases. To date, only invasive approaches provide clinically effective results. Ultrasound can be defined as the propagation of a high-frequency sound wave exposing the propagation media to mechanical and thermal effects. Ultrasound has been proposed as a non-invasive physical agent for increasing therapeutic agent delivery in various fields of medicine.Areas Covered: An update on recent advances in transscleral and transcorneal ultrasoundmediated drug delivery is presented. Efficient drug delivery is achieved in vitro, ex vivo and in vivo for various types of materials. Numerous studies indicate that efficacy is related to Downloaded by [University of Lethbridge] at 02:55 18 June 2016 2 cavitation. Although slight reversible effects can be observed on the corneal epithelium, efficient drug delivery can be performed without causing damage to the cornea. Expert Opinion: Recent developments prove the potential of ultrasound-mediated ocular drug delivery. Cavitation appears to be a preponderant mechanism, opening a way to treatment monitoring by cavitation measurement. Even if no clinical studies have yet been performed, the promising results summarized here are promoting developments toward clinical applications, particularly in assessing the safety of the technique. Article highlights box• Ocular drug delivery limits the treatment of numerous diseases because of anatomical and physiological barriers so that current techniques are either inefficient (5% of the dose reaching the interior of the eye) or invasive (intravitreal injections, implants).• Ultrasound offers the possibility of acting noninvasively on the sclera or cornea.• Both in vitro and in vivo experiments report an increase in transscleral and transcorneal drug delivery by applying ultrasound which could suggest an increased treatment efficacy.• The mechanism of enhanced drug delivery is attributable to cavitation, producing slight, reversible changes in tissues.• Slight reversible damages attributable could be found. Thus, with an efficient cavitation monitoring procedure, translation to the clinic should be encouraged, as no severe damage has been observed. Downloaded by [University of Lethbridge] at 02:55 18 June 2016 3• The strategy of dosing the ultrasound exposure on measured cavitation activity in relation with its calibrated bioeffects in terms of damages and efficacy is proposed.Also, future developments shall benefit from the experience of sonophoresis.

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“…Stable oscillations may create significant liquid flow around microbubbles. This is called microstreaming (Rooney 1972) and results in shear stresses on cell membranes. As microbubbles grow rapidly and collapse, they may generate a local shock wave in the fluid (Lentacker et al 2009).…”

Section: Physical Mechanismsmentioning

confidence: 99%