Shared Transcriptional Signatures in Major Depressive Disorder and Mouse Chronic Stress Models

Scarpa, Joseph R.; Fatma, Mena; Loh, Yong-Hwee Eddie; Traore, Said Romaric; Stefan, Théo; Chen, Ting Huei; Nestler, Eric J.; Labonté, Benoit

doi:10.1016/j.biopsych.2020.02.577

Cited by 6 publications

(3 citation statements)

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“…Work is currently underway to identify the molecular intersections between animal models of stress and postmortem tissue genomics work. One study compared a large postmortem, MDD cohort to three separate stress paradigms to identify whether one model better captured the molecular pathology of MDD than another ( Scarpa et al, 2020 ). Interestingly, the authors found that each model captured different aspects of the depression molecular signature.…”

Section: Exploring Stress Space With Transcriptomicsmentioning

confidence: 99%

“…There are currently major efforts to understand the molecular pathology of stress disorders. Preclinical work on stress disorders has been directed at understanding how much of the disease transcriptomic changes are recapitulated by each stress model ( Scarpa et al, 2020 ). Increased collection of human postmortem tissue from donors with psychiatric illness has contributed to advances in understanding the transcriptomic changes of MDD and PTSD and provided comprehensive genomic atlases which can be used to identify clinically relevant changes in animal model comparisons.…”

Section: Introductionmentioning

confidence: 99%

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Transcriptomics of the depressed and PTSD brain

Zhang

Kaye

Wang

et al. 2021

Neurobiology of Stress

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Stress is the response of an organism to demands for change, yet excessive or chronic stress contributes to nearly all psychiatric disorders. The advent of high-throughput transcriptomic methods such as single cell RNA sequencing poses new opportunities to understand the neurobiology of stress, yet substantial barriers to understanding stress remain. Stress adaptation is an organismal survival mechanism conserved across all organisms, yet there is an infinity of potential stressful experiences. Unraveling shared and separate transcriptional programs for adapting to stressful experience remains a challenge, despite methodological and analytic advances. Here we review the state of the field focusing on the technologies used to study the transcriptome for the stress neurobiologist, and also attempt to identify central questions about the heterogeneity of stress for those applying transcriptomic approaches. We further explore how postmortem transcriptome studies aided by preclinical animal models are converging on common molecular pathways for adaptation to aversive experience. Finally, we discuss approaches to integrate large genomic datasets with human neuroimaging and other datasets.

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Section: Exploring Stress Space With Transcriptomicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Transcriptomics of the depressed and PTSD brain

Zhang

Kaye

Wang

et al. 2021

Neurobiology of Stress

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“…Breast cancer patients are prone to presenting with agerelated cognitive deficits and/or cognitive decline during chemotherapy (6). Depression is a common psychological complication of breast cancer (7,8), which has profound effects on neural structure and function (9,10), and the presence of chronic stress has a major impact on depression (11,12). The incidence of depression in every generation Original Article worldwide is increasing (13,14).…”

Section: Introductionmentioning

confidence: 99%

The central nervous system can directly regulate breast cancer progression and blockage by quercetin

Luo¹,

Zhang²,

Liu³

et al. 2021

Ann Transl Med

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Background: Neuroinflammation involving the central nervous system (CNS), such as depression, is associated with a significantly increased risk of cancer and cancer-specific mortality due to breast cancer. It is of great significance to learn about the regulatory process of CNS in breast cancer progression.Methods: We established a depressive MMTV-PyVT mouse model. The expression levels of neurotransmitters in the serum of depression animal models were assessed by enzyme-linked immunosorbent assay (ELISA). Changes of the microglia cells in the mice's brains were evaluated by immunofluorescence and reverse transcription-polymerase chain reaction (RT-PCR). Breast cancer progression was assessed by immunohistochemistry (IHC) analysis. To further investigate the mechanism by which ant-depressant drugs disrupt breast cancer progression, protein sequencing and network pharmacology were applied to identify related targets. Furthermore, we used conditioned medium from BV-2 microglia to culture breast cancer cells and treated the cells with quercetin at different concentrations; cell viability was assessed by the MTT assay.Results: Our results show a possible regulatory target between neuroinflammation in the CNS and development of breast cancer, along with the reversal effect of quercetin on breast cancer progression.Conclusions: Chronic stress may be an indicator of breast cancer and that quercetin could be an effective treatment for breast cancer patients with chronic stress.

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Multi-omic molecular profiling and network biology for precision anaesthesiology: a narrative review

Scarpa

Elemento

2023

British Journal of Anaesthesia

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Shared Transcriptional Signatures in Major Depressive Disorder and Mouse Chronic Stress Models

Cited by 6 publications

References 0 publications

Transcriptomics of the depressed and PTSD brain

Transcriptomics of the depressed and PTSD brain

The central nervous system can directly regulate breast cancer progression and blockage by quercetin

Multi-omic molecular profiling and network biology for precision anaesthesiology: a narrative review

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