Shared and disparate components of the pathophysiologies of fetal growth restriction and preeclampsia

Ness, Roberta B.; Sibai, Bahaeddine M

doi:10.1016/j.ajog.2005.07.049

Cited by 403 publications

(334 citation statements)

References 162 publications

Supporting

Mentioning

311

Contrasting

Unclassified

Order By: Relevance

“…Insulin resistance has been proposed as a key factor in the development of HDP (6,25). Even in lean, normotensive pregnant women with normal glucose tolerance, insulin resistance at 16-20 weeks' gestation is predictive of subsequent preeclampsia (26).…”

Section: Discussionmentioning

confidence: 99%

“…Maternal obesity is associated with a complex interplay of metabolic abnormalities including hypertension, insulin resistance, hyperlipidemia, hypercoagulability, impaired endothelial function, inflammatory up-regulation (4), and altered adipokine profiles (5), which potentially contribute to the development of preeclampsia (6) and gestational hypertension.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Association of Hypertensive Disorders of Pregnancy with Weight Gain over the Subsequent 21 Years: Findings from a Prospective Cohort Study

Callaway

McIntyre

O’Callaghan

et al. 2007

American Journal of Epidemiology

View full text Add to dashboard Cite

Obesity is an important risk factor for hypertensive disorders of pregnancy, but most cases of hypertensive disorders of pregnancy occur in women of normal weight. There may be predisposing factors to both hypertensive disorders of pregnancy and obesity. To test this hypothesis, the authors compared changes in body mass index (weight (kg)/height (m) 2 ) over time in women with and without hypertensive disorders of pregnancy. They used data from 3,572 women who received antenatal care at a major public hospital in Brisbane, Australia, between 1981 and 1984 and who were followed up for 21 years. A total of 318 women (8.9%) had experienced hypertensive disorders in the index pregnancy, and 233 of them (73.3%) had a baseline body mass index of 25 kg/m 2 . After the authors adjusted for all potential confounding factors, they found that women with hypertensive disorders of pregnancy gained on average 1.35 kg/m 2 more (95% confidence interval: 0.80 kg/m 2 , 1.89 kg/m 2 ) in body mass index over 21 years than women without hypertensive disorders of pregnancy. The odds of gaining 5 kg/m 2 were 59% greater for women who experienced hypertensive disorders of pregnancy compared with those who did not (odds ratio = 1.59, 95% confidence interval: 1.24, 2.04). The authors concluded that hypertensive disorders of pregnancy are associated with increased weight gain over 21 years. body mass index; body weight; hypertension; pre-eclampsia; pregnancy; prospective studies; weight gain; women Abbreviations: BMI, body mass index; HDP, hypertensive disorders of pregnancy

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Association of Hypertensive Disorders of Pregnancy with Weight Gain over the Subsequent 21 Years: Findings from a Prospective Cohort Study

Callaway

McIntyre

O’Callaghan

et al. 2007

American Journal of Epidemiology

View full text Add to dashboard Cite

show abstract

“…38 It is believed that pre-eclampsia and FGR share common components in their pathogenesis, although some disparate findings have been described. 7,39 Furthermore, it has been suggested that FGR in pre-eclampsia represents the response to a fetal signal stimulated by reduced placental nutrient availability that is inadequate to overcome the subsequent malnutrition stress. Conversely, FGR without pre-eclampsia occurs as a result of the absence of this signal.…”

Section: Discussionmentioning

confidence: 99%

“…5,6 It is widely accepted that shallow trophoblast invasion can lead to fetal hypoxia and impaired growth. 7 Adequate proliferation and differentiation of villous cytotrophoblast into invasive extravillous trophoblast, a process that is controlled by hypoxia, is critical for successful placentation. 8,9 Thus, the entire repertoire of hypoxia-associated growth factors is remarkably active during placental development.…”

Section: Introductionmentioning

confidence: 99%

Reduced placental prolyl hydroxylase 3 mRNA expression in pregnancies affected by fetal growth restriction

Gourvas

Sifakis

Dalpa

et al. 2010

BJOG

View full text Add to dashboard Cite

Objective To investigate the role of the hypoxia-inducible factor (HIF) pathway in fetal growth restriction (FGR).Design A case-control study.Setting Research laboratory and gynaecology clinic.Sample Twenty placentas from normal pregnancies and 20 from FGR pregnancies.Methods RNA extraction, cDNA synthesis, quantitative real-time polymerase chain reaction (qRT-PCR) assay, statistical analysis.Main outcome measures mRNA expression of HIF-1a, HIF-2a and HIF-b (ARNT), along with prolyl hydroxylase domain 3 (PHD3), which leads to proteasomal degradation of HIF-a subunits.Results No statistically significant differences in the transcription levels of ARNT and HIF-2a were found between FGR and normal placentas. By contrast, PHD3 and HIF-1a mRNA were downregulated in FGR placentas. PHD3 mRNA expression was associated with gestational age at delivery (P = 0.008), birthweight centile (P = 0.029) and abnormal umbilical artery (UA) Doppler measurements (P = 0.034).Conclusions As PHD3 regulates the HIF-mediated hypoxic response in FGR, we deduce that fetal adaptation to hypoxia ranges from impaired to adequate, as observed by the gradient of PHD3 downregulation in relation to the severity of FGR.

show abstract

“…Furthermore, differences in scorpion species and their venom composition may explain the divergence in the results (1). Commonly, this disordered intrauterine growth of fetus organs can be justified by two mechanisms: a defective placental function resulting from placenta narrowness and perfusion alterations; and maternal hypertension and metabolic disorders (20,21,23,24). As the repetitive venom injection induces intermittent hypertension, it will indirectly results in fetal growth disorder (25).…”

Section: Figurementioning

confidence: 99%

Embryotoxicity following repetitive maternal exposure to scorpion venom

Hmed¹,

Badraoui²,

Serria³

et al. 2012

J. Venom. Anim. Toxins incl. Trop. Dis

View full text Add to dashboard Cite

Abstract:Although it is a frequent accident in a few countries, scorpion envenomation during pregnancy remains scarcely studied. In the present study, the effects of repetitive maternal exposure to Buthus occitanus tunetanus venom are investigated and its possible embryotoxic consequences on rats. Primigravid rats received a daily intraperitoneal dose of 1 mL/kg of saline solution or 300 µg/kg of crude scorpion venom, from the 7 th to the 13 th day of gestation. On the 21 st day, the animals were deeply anesthetized using diethylether. Then, blood was collected for chemical parameter analysis. Following euthanasia, morphometric measurements were carried out. The results showed a significant increase in maternal heart and lung absolute weights following venom treatment. However, the mean placental weight per rat was significantly diminished. Furthermore, blood urea concentration was higher in exposed rats (6.97 ± 0.62 mmol/L) than in those receiving saline solution (4.94 ± 0.90 mmol/L). Many organs of venom-treated rat fetuses (brain, liver, kidney and spleen) were smaller than those of controls. On the contrary, fetal lungs were significantly heavier in fetuses exposed to venom (3.2 ± 0.4 g) than in the others (3.0 ± 0.2 g). Subcutaneous blood clots, microphthalmia and total body and tail shortening were also observed in venom-treated fetuses. It is concluded that scorpion envenomation during pregnancy potentially causes intrauterine fetal alterations and growth impairment.

show abstract

Shared and disparate components of the pathophysiologies of fetal growth restriction and preeclampsia

Cited by 403 publications

References 162 publications

The Association of Hypertensive Disorders of Pregnancy with Weight Gain over the Subsequent 21 Years: Findings from a Prospective Cohort Study

The Association of Hypertensive Disorders of Pregnancy with Weight Gain over the Subsequent 21 Years: Findings from a Prospective Cohort Study

Reduced placental prolyl hydroxylase 3 mRNA expression in pregnancies affected by fetal growth restriction

Embryotoxicity following repetitive maternal exposure to scorpion venom

Contact Info

Product

Resources

About