Shaping the risk for late-life neurodegenerative disease: A systematic review on prenatal risk factors for Alzheimer’s disease-related volumetric brain biomarkers

Boots, Amber; Wiegersma, Aline Marileen; Vali, Yasaman; Hof, Malon Van den; Langendam, Miranda; Limpens, Jacqueline; Backhouse, Ellen V.; Shenkin, Susan D.; Roseboom, Tessa J.; Rooij, Susanne R. de

doi:10.1016/j.neubiorev.2022.105019

Cited by 9 publications

(5 citation statements)

References 111 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These associations may be particularly vulnerable to unobserved confounding and se lection effects, most importantly by maternal mental health and behaviour. Cyclical relationships between poor perinatal men tal health, social adversity, maternal stress, maternal behaviour (in cluding alcohol and substance use), maternal care and prena tal nutrition 83 may lead to a sociodevelopmental cascade that in creases exposure to adverse child outcomes (all of which have been associated with risk of mental disorders), including early life infec tions (with a stronger relationship between some infections and psychosis 68 rather than depression 84 ), obstetric complications 68,85 , altered neurodevelopment 86 , childhood adversities 87 , and behav ioural and mental health difficulties 88 . If proven, this would warrant public mental health strategies focused on improving prenatal ma ternal, parental and familial conditions as an intervention strategy that could benefit multiple parentchild outcomes.…”

Section: Early Life Adversitymentioning

confidence: 99%

The social determinants of mental health and disorder: evidence, prevention and recommendations

Kirkbride,

Anglin,

Colman

et al. 2024

World Psychiatry

View full text Add to dashboard Cite

People exposed to more unfavourable social circumstances are more vulnerable to poor mental health over their life course, in ways that are often determined by structural factors which generate and perpetuate intergenerational cycles of disadvantage and poor health. Addressing these challenges is an imperative matter of social justice. In this paper we provide a roadmap to address the social determinants that cause mental ill health. Relying as far as possible on high‐quality evidence, we first map out the literature that supports a causal link between social determinants and later mental health outcomes. Given the breadth of this topic, we focus on the most pervasive social determinants across the life course, and those that are common across major mental disorders. We draw primarily on the available evidence from the Global North, acknowledging that other global contexts will face both similar and unique sets of social determinants that will require equitable attention. Much of our evidence focuses on mental health in groups who are marginalized, and thus often exposed to a multitude of intersecting social risk factors. These groups include refugees, asylum seekers and displaced persons, as well as ethnoracial minoritized groups; lesbian, gay, bisexual, transgender and queer (LGBTQ+) groups; and those living in poverty. We then introduce a preventive framework for conceptualizing the link between social determinants and mental health and disorder, which can guide much needed primary prevention strategies capable of reducing inequalities and improving population mental health. Following this, we provide a review of the evidence concerning candidate preventive strategies to intervene on social determinants of mental health. These interventions fall broadly within the scope of universal, selected and indicated primary prevention strategies, but we also briefly review important secondary and tertiary strategies to promote recovery in those with existing mental disorders. Finally, we provide seven key recommendations, framed around social justice, which constitute a roadmap for action in research, policy and public health. Adoption of these recommendations would provide an opportunity to advance efforts to intervene on modifiable social determinants that affect population mental health.

show abstract

Section: Early Life Adversitymentioning

confidence: 99%

The social determinants of mental health and disorder: evidence, prevention and recommendations

Kirkbride,

Anglin,

Colman

et al. 2024

World Psychiatry

View full text Add to dashboard Cite

show abstract

“…Few studies have examined other prenatal exposures such as smoking, alcohol, preeclampsia and gestational diabetes, and later-life CVD. These exposures are associated with smaller brain volumes in children and adults 29 and increased blood pressure and stroke risk in adulthood in some, 30 , 31 but not all, studies. 32 However associations have not been examined in relation to other markers of SVD.…”

Section: Developmental Origins Of Health and Disease And Cerebrovascu...mentioning

confidence: 99%

Cerebral Small Vessel Disease: Early-Life Antecedents and Long-Term Implications for the Brain, Aging, Stroke, and Dementia

Backhouse,

Boardman,

Wardlaw

2024

Hypertension

View full text Add to dashboard Cite

Cerebral small vessel disease is common in older adults and increases the risk of stroke, cognitive impairment, and dementia. While often attributed to midlife vascular risk factors such as hypertension, factors from earlier in life may contribute to later small vessel disease risk. In this review, we summarize current evidence for early-life effects on small vessel disease, stroke and dementia focusing on prenatal nutrition, and cognitive ability, education, and socioeconomic status in childhood. We discuss possible reasons for these associations, including differences in brain resilience and reserve, access to cognitive, social, and economic resources, and health behaviors, and we consider the extent to which these associations are independent of vascular risk factors. Although early-life factors, particularly education, are major risk factors for Alzheimer disease, they are less established in small vessel disease or vascular cognitive impairment. We discuss current knowledge, gaps in knowledge, targets for future research, clinical practice, and policy change.

show abstract

“…24 ) and may result in reduced grey matter or total brain volume. [25][26][27] Collectively these could limit the brain reserve capacity of an individual, 28 and therefore increase the risk of cognitive impairment or neurodegeneration. Similarly, in the context of preterm birth as a risk factor for later life cerebrovascular disease (CVD), there may be a genetic element to this risk in addition to any developmental or injury induced component.…”

Section: Early-life Events As Risk Factors For Long-term Neurological...mentioning

confidence: 99%

Developmental priming of early cerebrovascular ageing: Implications across a lifetime

Stolp,

Solito

2024

Int J Geriat Psychiatry

View full text Add to dashboard Cite

IntroductionNeurological conditions such as Alzheimer's disease and stroke represent a substantial health burden to the world's ageing population. Cerebrovascular dysfunction is a key contributor to these conditions, affecting an individual's risk profile, age of onset, and severity of neurological disease. Recent data shows that early‐life events, such as maternal health during pregnancy, birth weight and exposure to environmental toxins can ‘prime’ the vascular system for later changes. With age, blood vessels can become less flexible and more prone to damage. This can lead to reduced blood flow to the brain, which is associated with cognitive decline and an increased risk of stroke and other cerebrovascular diseases. These in turn increase the risk of vascular dementia and Alzheimer's disease.ObjectivesWe aim to explore how early life factors influence cerebrovascular health, ageing and disease.MethodsWe have reviewed recently published literature from epidemiological studies, clinical cases and basic research which explore mechanisms that contribute to cerebrovascular and blood‐brain barrier dysfunction, with a particularly focus on those that assess contribution of early‐life events or vascular priming to subsequent injury.ResultsPerinatal events have been linked to acute cerebrovascular dysfunction and long‐term structural reorganisation. Systemic disease throughout the lifetime that produce inflammatory or oxidative stress may further sensitise the cerebrovasculature to disease and contribute to neurodegeneration.ConclusionsBy identifying these early‐life determinants and understanding their mechanisms, scientists aim to develop strategies for preventing or mitigating cerebrovascular ageing‐related issues.

show abstract

Shaping the risk for late-life neurodegenerative disease: A systematic review on prenatal risk factors for Alzheimer’s disease-related volumetric brain biomarkers

Cited by 9 publications

References 111 publications

The social determinants of mental health and disorder: evidence, prevention and recommendations

The social determinants of mental health and disorder: evidence, prevention and recommendations

Cerebral Small Vessel Disease: Early-Life Antecedents and Long-Term Implications for the Brain, Aging, Stroke, and Dementia

Developmental priming of early cerebrovascular ageing: Implications across a lifetime

Contact Info

Product

Resources

About