Shaping the next steps of research on frailty: challenges and opportunities

Aprahamian, Ivan; Xue, Qian

doi:10.1186/s12877-021-02370-z

Cited by 11 publications

(8 citation statements)

References 30 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increased recognition of frailty without face-to-face examination [ 10 ]. Multinational epidemiological surveys have shown the global nature of frailty which has a prevalence of between 12 and 24% among community dwelling older adults [ 11 ]. Multimorbidity interact with frailty, and patients with chronic multimorbidity are more likely to develop frailty than the general elderly [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Research on the frailty status and adverse outcomes of elderly patients with multimorbidity

et al. 2022

BMC Geriatr

View full text Add to dashboard Cite

Background As patients age, the frailty of those with multimorbidity increases, often resulting in adverse health outcomes. The current study investigated the frailty status and the factors which influence it in elderly patients with multimorbidity in Chinese hospitals. The relationship between the frailty of patients with multimorbidity and adverse outcomes was explored. Methods The current prospective cohort study investigated inpatients in the internal medicine department of 5 tertiary hospitals in Sichuan Province, China. A total of 3836 elderly patients with multimorbidity were enrolled. Frailty was assessed using the FRAIL scale and adverse outcome events occurring during hospitalization were tracked. Descriptive statistics and logistic regressions were used for data analysis. Results The prevalence of frailty was 27.2% and of pre-frailty, 58.9%. Logistic regression analysis showed that increasing age, low BMI, low education level, lack of exercise, multiple types of medications and multiple numbers of chronic diseases were the main risk factors for frailty in elderly patients with multimorbidity (OR values: 1.020, 1.469, 2.350, 2.836, 1.156 and 1.308, respectively). The incidence of adverse outcomes was 13.9% among the cohort with the most common being deep vein thrombosis (42.4%), followed by pressure injury (38.8%). Regression analysis showed a significant correlation of frailty with adverse outcome (OR: 1.496; p < 0.01). Conclusions The prevalence of frailty and pre-frailty in hospitalized elderly patients with multimorbidity was high. Increasing age, low BMI, low education level, lack of exercise, multiple types of medications and multiple numbers of chronic diseases were factors which influenced frailty and frailty was an important factor in the occurrence of adverse outcomes. The most common adverse outcome of elderly multimorbidity patients during hospitalization was deep vein thrombosis.

show abstract

Section: Introductionmentioning

confidence: 99%

Research on the frailty status and adverse outcomes of elderly patients with multimorbidity

et al. 2022

BMC Geriatr

View full text Add to dashboard Cite

show abstract

“…As the HYVET study [9] suggested in 2015, more prospective research is needed to evaluate this association but since then less is done to fill this gap. There has been a recent call [38,39] to increase the number of studies incorporating the frailty syndrome and identifying new frailty/healthy aging markers to prevent frailty occurrence or progression is extremely important.…”

Section: Discussionmentioning

confidence: 99%

The influence of hypertension management on frailty prevention among older persons aged 65 and over: a systematic review

Qipo

Debain²,

Bautmans³

et al. 2022

Aging Clin Exp Res

View full text Add to dashboard Cite

Background Frailty and hypertension are interrelated, but it remains unclear whether this relationship is modified by antihypertensive drugs. Methods and results A systematic review of PubMed and Web of Science databases was performed to review the influence of hypertension management on preventing the occurrence or progression of frailty in older people aged 65 and over. Studies providing information on this association regardless of the study setting, or definition of hypertension and frailty were included. Among the initial 2298 articles identified, 7 were included in the review. Three observational studies assessed the association between frailty and hypertension. Two of them reported no relationship between Aldosterone Antagonists use and frailty prevention. No relationship between BP and incidence frailty after adjustment for hypertension treatment was observed in two other articles. An indirect relationship was reported in the RCTs included. Higher AT11RaAb levels (control group), can lead to a generalized weakness/frailty risk shown by a decrease in grip strength (r = -0.57, p < 0.005) and walking speed (r = -0.47, p < 0.005). No significant differences between int-hypertensive intervention and control were observed in frailty status after a 12-weeks follow-up after applying three different frailty measurement tools in the other RCT. Conclusions Based on the results of this systematic review we conclude that BP and frailty occur together but whether the treatment with anti-hypertensive drugs modifies this relationship remains unclear and needs to be further investigated.

show abstract

“…Previous research has proposed that disability may be one of the main drivers of frailty in pwMS [6]. In other words, the onset of MS-related disability may antecede the manifestation of frailty, a condition often referred to as secondary frailty [30], which differs in etiology from primary frailty (i.e., due to aging processes). In this respect, it should be noted that participants in the current study had a median age of 60 years and that no correlation between…”

Section: Plos Onementioning

confidence: 99%

Frailty among people with multiple sclerosis who are wheelchair users

2022

View full text Add to dashboard Cite

Background Frailty is a biological syndrome arising from cumulative declines across multiple physiologic systems. Although recent reports have described elevated frailty levels in people with multiple sclerosis (MS) with minimal to moderate disability, very little is known about frailty in individuals with severe disability. The objective of the current investigation was to evaluate frailty through the deficit accumulation model and to explore the relationship of frailty with MS clinical subtypes, disease duration and fall-history in wheelchair users living with MS. Materials and methods Standard validated procedures were used to calculate a frailty index in 45 wheelchair and scooter users living with MS (median age = 60.0[16.0] years, 82.2% female, patient determined disease steps score = 7.0). Information on demographics, MS clinical subtypes, disease duration, and six-month fall-history were collected as part of a standardized medical survey. Results The mean frailty index score was 0.54 (standard deviation = 0.13). Overall, 91.1% and 8.9% of participants met objective diagnostic criteria for severe and moderate frailty, respectively. A one-way ANOVA revealed no significant differences (F = 0.054, p = 0.948) in the frailty index among participants with relapsing-remitting MS, primary progressive, and secondary progressive MS. No relationship between frailty and disease duration (r = -0.058, p = 0.706) was found. A univariable negative binomial regression analysis revealed a significant association between frailty index scores and the number of falls experienced in the previous six months (IRR = 1.75, 95% CI [1.06–2.91], p = 0.030). Conclusion The current study suggests that individuals with MS with advanced disability also live with coexisting frailty and that the frailty index may be a valuable tool in evaluating fall-risk in wheelchair users living with MS. The significant overlap observed between severe disability and severe frailty highlights the emerging need to untangle this bi-directional relationship to identify appropriate therapeutic pathways in the MS population living with advanced disability.

show abstract

Shaping the next steps of research on frailty: challenges and opportunities

Cited by 11 publications

References 30 publications

Research on the frailty status and adverse outcomes of elderly patients with multimorbidity

Research on the frailty status and adverse outcomes of elderly patients with multimorbidity

The influence of hypertension management on frailty prevention among older persons aged 65 and over: a systematic review

Frailty among people with multiple sclerosis who are wheelchair users

Contact Info

Product

Resources

About