Shaping the future: recent advances of 3D printing in drug delivery and healthcare

Trenfield, Sarah J.; Awad, Atheer; Madla, Christine M.; Hatton, Grace B.; Firth, Jack; Goyanes, Álvaro; Gaisford, Simon; Basit, Abdul W.

doi:10.1080/17425247.2019.1660318

Cited by 222 publications

(108 citation statements)

References 102 publications

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“…Three-dimensional printing (3DP) is an innovative additive manufacturing technology that has come to the fore in the preparation of personalised dose printlets (3D printed tablets) [10][11][12][13][14]. 3D printing is an umbrella term that encompasses various technologies, many of which have already been evaluated in the pharmaceutical field [15][16][17][18], including powder bed inkjet printing, fused deposition modelling (FDM) [19][20][21][22][23][24][25][26][27], semi-solid extrusion (SSE) [28][29][30][31][32][33], selective laser sintering (SLS), direct powder extrusion (DPE) [34] and stereolithography (SLA) [15,[35][36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron

Allahham¹,

Fina

Marcuta³

et al. 2020

Pharmaceutics

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142

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The aim of this work was to explore the feasibility of using selective laser sintering (SLS) 3D printing (3DP) to fabricate orodispersable printlets (ODPs) containing ondansetron. Ondansetron was first incorporated into drug-cyclodextrin complexes and then combined with the filler mannitol. Two 3D printed formulations with different levels of mannitol were prepared and tested, and a commercial ondansetron orally disintegrating tablet (ODT) product (Vonau® Flash) was also investigated for comparison. Both 3D printed formulations disintegrated at ~15 s and released more than 90% of the drug within 5 min independent of the mannitol content; these results were comparable to those obtained with the commercial product. This work demonstrates the potential of SLS 3DP to fabricate orodispersible printlets with characteristics similar to a commercial ODT, but with the added benefit of using a manufacturing technology able to prepare medicines individualized to the patient.

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Section: Introductionmentioning

confidence: 99%

Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron

Allahham¹,

Fina

Marcuta³

et al. 2020

Pharmaceutics

Self Cite

142

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“…A potential technology to produce the aforementioned meshes is 3D printing. This technology allows clinicians to prepare devices adapted to patient's anatomy and requirements [14][15][16][17]. Furthermore, a wide range of materials can be used for 3D printing applications.…”

Section: Introductionmentioning

confidence: 99%

3D Printing of Drug-Loaded Thermoplastic Polyurethane Meshes: A Potential Material for Soft Tissue Reinforcement in Vaginal Surgery

et al. 2020

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Current strategies to treat pelvic organ prolapse (POP) or stress urinary incontinence (SUI), include the surgical implantation of vaginal meshes. Recently, there have been multiple reports of issues generated by these meshes conventionally made of poly(propylene). This material is not the ideal candidate, due to its mechanical properties leading to complications such as chronic pain and infection. In the present manuscript, we propose the use of an alternative material, thermoplastic polyurethane (TPU), loaded with an antibiotic in combination with fused deposition modelling (FDM) to prepare safer vaginal meshes. For this purpose, TPU filaments containing levofloxacin (LFX) in various concentrations (e.g., 0.25%, 0.5%, and 1%) were produced by extrusion. These filaments were used to 3D print vaginal meshes. The printed meshes were fully characterized through different tests/analyses such as fracture force studies, attenuated total reflection-Fourier transform infrared, thermal analysis, scanning electron microscopy, X-ray microcomputed tomography (μCT), release studies and microbiology testing. The results showed that LFX was uniformly distributed within the TPU matrix, regardless the concentration loaded. The mechanical properties showed that poly(propylene) (PP) is a tougher material with a lower elasticity than TPU, which seemed to be a more suitable material due to its elasticity. In addition, the printed meshes showed a significant bacteriostatic activity on both Staphylococcus aureus and Escherichia coli cultures, minimising the risk of infection after implanting them. Therefore, the incorporation of LFX to the TPU matrix can be used to prepare anti-infective vaginal meshes with enhanced mechanical properties compared with current PP vaginal meshes.

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“…Selective laser sintering (SLS) is a powder-based 3D printing technology in which a laser beam is used to selectively bind powder particles together to create 3D objects [48][49][50]. SLS 3D printing is used in the fields of tissue engineering to produce scaffolds [51][52][53][54][55], and drug delivery to fabricate printlets with different release characteristics such as orally disintegrating [56][57][58], immediate release and modified release dosage forms [59].…”

Section: Introductionmentioning

confidence: 99%

3D Printed Tablets (Printlets) with Braille and Moon Patterns for Visually Impaired Patients

et al. 2020

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Visual impairment and blindness affects 285 million people worldwide, resulting in a high public health burden. This study reports, for the first time, the use of three-dimensional (3D) printing to create orally disintegrating printlets (ODPs) suited for patients with visual impairment. Printlets were designed with Braille and Moon patterns on their surface, enabling patients to identify medications when taken out of their original packaging. Printlets with different shapes were fabricated to offer additional information, such as the medication indication or its dosing regimen. Despite the presence of the patterns, the printlets retained their original mechanical properties and dissolution characteristics, wherein all the printlets disintegrated within ~5 s, avoiding the need for water and facilitating self-administration of medications. Moreover, the readability of the printlets was verified by a blind person. Overall, this novel and practical approach should reduce medication errors and improve medication adherence in patients with visual impairment.

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Shaping the future: recent advances of 3D printing in drug delivery and healthcare

Cited by 222 publications

References 102 publications

Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron

Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron

3D Printing of Drug-Loaded Thermoplastic Polyurethane Meshes: A Potential Material for Soft Tissue Reinforcement in Vaginal Surgery

3D Printed Tablets (Printlets) with Braille and Moon Patterns for Visually Impaired Patients

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