“…Considering that the statistical significance is dependent on the sample variance, 35 the larger standard deviation of the results may have contributed to the statistical similarities among the analyses performed at different voxel sizes. Several studies that have evaluated debris accumulations by micro-CT have also shown a large standard deviation 2,4,7,8,11,12 or non-normal distribution of data. 5,6 Even using methods that improve the sample selection criteria, such as micro-CT analyses for tooth selection and sample randomization, 5 it is difficult to standardize the debris accumulated in each root canal after its preparation.…”