Shape Selectivity in Primate Frontal Eye Field

Peng, Xinmiao; Sereno, Margaret E.; Silva, Amanda K.; Lehky, Sidney R.; Sereno, Anne B.

doi:10.1152/jn.01188.2007

Cited by 57 publications

(53 citation statements)

References 80 publications

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“…However, the visual capabilities of FEF neurons may be underappreciated. Reports have found feature selectivity in FEF (e.g., Bichot et al 1996;Peng et al 2008) and support a role for it in top-down control of feature attention (Zhou and Desimone 2011).…”

Section: Behavioral Implications Of Remappingmentioning

confidence: 89%

Circuits for presaccadic visual remapping

Rao

Mayo

Sommer

2016

Journal of Neurophysiology

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Saccadic eye movements rapidly displace the image of the world that is projected onto the retinas. In anticipation of each saccade, many neurons in the visual system shift their receptive fields. This presaccadic change in visual sensitivity, known as remapping, was first documented in the parietal cortex and has been studied in many other brain regions. Remapping requires information about upcoming saccades via corollary discharge. Analyses of neurons in a corollary discharge pathway that targets the frontal eye field (FEF) suggest that remapping may be assembled in the FEF's local microcircuitry. Complementary data from reversible inactivation, neural recording, and modeling studies provide evidence that remapping contributes to transsaccadic continuity of action and perception. Multiple forms of remapping have been reported in the FEF and other brain areas, however, and questions remain about the reasons for these differences. In this review of recent progress, we identify three hypotheses that may help to guide further investigations into the structure and function of circuits for remapping. eye movements; perception; remapping; saccades; vision WE PERCEIVE THE ENVIRONMENT as continuous, but neurons in the brain take samples that are constrained in space and time. Specific ranges of stimuli drive a neuron to produce action potentials. From the 1960s through the 1970s, it was essentially dogma that the stimulus-spike relationship of a sensory neuron revealed its "receptive field," the portion of the world to which a sensory neuron responds. Response gain could be modulated by internal factors such as attention or external factors such as contrast, but the structure of receptive fields seemed immutable and their function, to report what is out there, seemed passive. In the case of the visual system, neurons were assumed to have static receptive fields relative to the fovea.Evidence for exceptions to this rule emerged in the 1980s, and the dogma was overturned in the 1990s, when behaving animal preparations allowed for studies in which eye movements were incorporated as factors in experimental design. It became clear that around the time of saccades the spatial structure of receptive fields can change. Here we summarize the advances in our understanding of labile receptive field location with a focus on circuit-level studies from the past 20 years. Progress has been made in elucidating the mechanisms of receptive field remapping both at the macrocircuit level (pathways between brain areas) and the microcircuit level (processing within brain areas). Recent physiological and modeling experiments have leveraged this circuit information to explore the visuomotor and perceptual functions of remapping. Taken together, a new picture of the genesis and role of presaccadic remapping emerges, yielding testable hypotheses for future work. Presaccadic Visual RemappingThe first hint that visual receptive fields can be spatially dynamic was reported by Mays and Sparks (1980) in a study of neurons located in the intermediate...

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Section: Behavioral Implications Of Remappingmentioning

confidence: 89%

Circuits for presaccadic visual remapping

Rao

Mayo

Sommer

2016

Journal of Neurophysiology

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“…This is not the first observation of noncorrespondence in shape selectivity. In a frontal eye field study where cells were tested for object selectivity in a fixation task and a delayed match to sample task (DMTS), only 5 of 65 neurons had selectivity in both tasks (Peng et al 2008). When only most and least preferred shapes in the two tasks were compared, selectivity seemed largely consistent, but when the order of preference across the range of shapes was compared, the correspondence was far less consistent.…”

Section: Discussionmentioning

confidence: 99%

“…At the single-neuron level, we first focused our analysis on neurons that were shape selective in both tasks (n ϭ 11). We used a procedure similar to that described by Peng et al (2008) to determine whether individual neurons were selective for the same shapes in each task. For each neuron, we selected the two most preferred shapes and one least preferred shape in the single step.…”

Section: ϫ8mentioning

confidence: 99%

Shape selectivity and remapping in dorsal stream visual area LIP

Subramanian

Colby

2014

Journal of Neurophysiology

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Subramanian J, Colby CL. Shape selectivity and remapping in dorsal stream visual area LIP. J Neurophysiol 111: 613-627, 2014. First published November 13, 2013 doi:10.1152/jn.00841.2011.-We explore the visual world by making rapid eye movements (saccades) to focus on objects and locations of interest. Despite abrupt retinal image shifts, we see the world as stable. Remapping contributes to visual stability by updating the internal image with every saccade. Neurons in macaque lateral intraparietal cortex (LIP) and other brain areas update information about salient locations around the time of a saccade. The depth of information transfer remains to be thoroughly investigated. Area LIP, as part of the dorsal visual stream, is regarded as a spatially selective area, yet there is evidence that LIP neurons also encode object features. We sought to determine whether LIP remaps shape information. This knowledge is important for understanding what information is retained from each glance. We identified 82 remapping neurons. First, we presented shapes within the receptive field and tested for shape selectivity in a fixation task. Among the remapping neurons, 28 neurons (34%) were selective for shape. Second, we presented the same shapes in the future location of the receptive field around the time of the saccade and tested for shape selectivity during remapping. Thirty-one (38%) neurons were selective for shape. Of 11 neurons that were shape selective in both tasks, 5 showed significant correlation between shape selectivity in the two tasks. Across the population, there was a weak but significant correlation between responses to shape in the two tasks. Our results provide neurophysiological evidence that remapped responses in area LIP can encode shape information as well as spatial information.

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“…However, recent studies have revealed that FEF neurons can have visual responses that are selective to stimulus shape (Peng et al, 2008), and monkeys can detect microstimulation of the FEF at intensities well below the levels needed to trigger saccades (Murphey and Maunsell, 2008). Both these results suggest that FEF may be closer to sensory analysis than previously believed.…”

Section: Introductionmentioning

confidence: 85%

Ultra-Rapid Sensory Responses in the Human Frontal Eye Field Region

Kirchner¹,

Barbeau²,

Thorpe³

et al. 2009

Journal of Neuroscience

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Most of what we know about the human frontal eye field (FEF) is extrapolated from studies in animals. There is ample evidence that this region is crucial for eye movements. However, evidence is accumulating that this region also plays a role in sensory processing and that it belongs to a "fast brain" system. We set out to investigate these issues in humans, using intracerebral recordings in patients with drug-refractory epilepsy. Event-related potential recordings were obtained from 11 epileptic patients from within the FEF region while they passed a series of visual and auditory perceptual tests. No eye movement was required. Ultra-rapid responses were observed, with mean onset latencies at 24 ms after stimulus to auditory stimuli and 45 ms to visual stimuli. Such early responses were compatible with cortical routes as assessed with simultaneous recordings in primary auditory and visual cortices. Components were modulated very early by the sensory characteristics of the stimuli, in the 30 -60 ms period for auditory stimuli and in the 45-60 ms period for visual stimuli. Although the frontal lobes in humans are generally viewed as being involved in high-level cognitive processes, these results indicate that the human FEF is a remarkably quickly activated multimodal region that belongs to a network of low-level neocortical sensory areas.

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Shape Selectivity in Primate Frontal Eye Field

Cited by 57 publications

References 80 publications

Circuits for presaccadic visual remapping

Circuits for presaccadic visual remapping

Shape selectivity and remapping in dorsal stream visual area LIP

Ultra-Rapid Sensory Responses in the Human Frontal Eye Field Region

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