Ultra-Rapid Sensory Responses in the Human Frontal Eye Field Region

Kirchner, Holle; Barbeau, Emmanuel J.; Thorpe, Simon J.; Régis, Jean; Liégeois‐Chauvel, Catherine

doi:10.1523/jneurosci.1233-09.2009

Cited by 93 publications

(70 citation statements)

References 128 publications

(47 reference statements)

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“…In our retinotopic paradigm, which emphasized eventrelated responses, we might expect to see the synaptic inputs in the low-frequency bands, including the alpha band, before the spiking outputs and the HGP Ray et al, 2008Ray et al, , 2011. In fact, several studies using event-related potentials reported very early RLs, which might reflect synaptic inputs rather than spiking activity (Chen et al, 2007;Kirchner et al, 2009). Indeed, our VEP analyses replicated these findings (see Fig.…”

Section: Longest Rls In the Alpha Bandsupporting

confidence: 79%

Frequency-dependent spatiotemporal profiles of visual responses recorded with subdural ECoG electrodes in awake monkeys: Differences between high- and low-frequency activity

2016

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Electrocorticography (ECoG) constitutes a powerful and promising neural recording modality in humans and animals. ECoG signals are often decomposed into several frequency bands, among which the so-called high-gamma band (80-250Hz) has been proposed to reflect local cortical functions near the cortical surface below the ECoG electrodes. It is typically assumed that the lower the frequency bands, the lower the spatial resolution of the signals; thus, there is not much to gain by analyzing the event-related changes of the ECoG signals in the lower-frequency bands. However, differences across frequency bands have not been systematically investigated. To address this issue, we recorded ECoG activity from two awake monkeys performing a retinotopic mapping task. We characterized the spatiotemporal profiles of the visual responses in the time-frequency domain. We defined the preferred spatial position, receptive field (RF), and response latencies of band-limited power (BLP) (i.e., alpha [3.9-11.7Hz], beta [15.6-23.4Hz], low [30-80Hz] and high [80-250Hz] gamma) for each electrode and compared them across bands and time-domain visual evoked potentials (VEPs). At the population level, we found that the spatial preferences were comparable across bands and VEPs. The high-gamma power showed a smaller RF than the other bands and VEPs. The response latencies for the alpha band were always longer than the latencies for the other bands and fastest in VEPs. Comparing the response profiles in both space and time for each cortical region (V1, V4+, and TEO/TE) revealed regional idiosyncrasies. Although the latencies of visual responses in the beta, low-, and high-gamma bands were almost identical in V1 and V4+, beta and low-gamma BLP occurred about 17ms earlier than high-gamma power in TEO/TE. Furthermore, TEO/TE exhibited a unique pattern in the spatial response profile: the alpha and high-gamma responses tended to prefer the foveal regions, whereas the beta and low-gamma responses preferred the peripheral visual fields with larger RFs. This suggests that neurons in TEO/TE first receive less selective spatial information via beta and low-gamma BLP but later receive more fine-tuned spatial foveal information via high-gamma power. This result is consistent with a hypothesis previously proposed by Nakamura et al. (1993) that states that visual processing in TEO/TE starts with coarse-grained information, which primes subsequent fine-grained information. Collectively, our results demonstrate that ECoG can be a potent tool for investigating the nature of the neural computations in each cortical region that cannot be fully understood by measuring only the spiking activity, through the incorporation of the knowledge of the spatiotemporal characteristics across all frequency bands.

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Section: Longest Rls In the Alpha Bandsupporting

confidence: 79%

Frequency-dependent spatiotemporal profiles of visual responses recorded with subdural ECoG electrodes in awake monkeys: Differences between high- and low-frequency activity

2016

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“…Consistent with these findings, attending to task-relevant stimulus features strongly activates the PPC and the FEF (Corbetta et al, 2000;Hopfinger et al, 2000;Indovina and Macaluso, 2007). As the FEF responds extremely quickly to sensory stimulation, the propagation of task-related modulation of activity through the attention network may have its origin here (Fecteau and Munoz, 2006;Buschman and Miller, 2007;Kirchner et al, 2009).…”

Section: Introductionsupporting

confidence: 57%

The Dorsal Attention Network Mediates Orienting toward Behaviorally Relevant Stimuli in Spatial Neglect

Ptak

Schnider²

2010

J. Neurosci.

119

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Experimental neurophysiology and functional neuroimaging have identified a dorsal attention network that encodes neural signals related to the behavioral significance of a stimulus. The core anatomical areas of this network are the frontal eye fields and the posterior parietal cortex, which are interconnected by the superior longitudinal fasciculus. Here, we show that damage or disconnection of this network predicts the extent to which task-relevant stimuli capture attention of human stroke patients with spatial neglect. Healthy volunteers, right-hemisphere-damaged control participants, and patients with left neglect reacted to peripheral targets defined by their color, which were preceded by a brief distracter stimulus. The position of the distracter and its relevance for the current trial were independently varied. In neglect patients with damage including the frontal eye fields and the superior longitudinal fasciculus, ipsilesional distracters impaired orienting into contralesional space regardless of their relevance for the current task. In contrast, patients with sparing of these regions were only impaired when distracters were task-relevant. These findings indicate that the dorsal attention network controls spatial orienting by modulating the saliency of distracter stimuli according to current action goals.

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“…Eye movements to the memorized color, when compared to onsets in the same condition, led to the shortest saccade latencies. This effect was small (about 40 ms) but significant, and it suggests that object memory is able to influence saccade programming at a very early stage (Kirchner, Barbeau, Thorpe, Régis, & Liégeois-Chauvel, 2009). …”

Section: Discussionmentioning

confidence: 94%

The interaction between memorized objects and abrupt onsets in oculomotor capture

Wong

Peterson

2011

Atten Percept Psychophys

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Recent evidence has been found for a source of task-irrelevant oculomotor capture (defined as when a salient event draws the eyes away from a primary task) that originates from working memory. An object memorized for a nonsearch task can capture the eyes during search. Here, an experiment was conducted that generated interactions between the presence of a memorized object (a colored disk) with the abrupt onset of a new object during visual search. The goal was to compare memory-driven oculomotor capture to oculomotor capture caused by an abrupt onset. This has implications for saccade programming theories, which have little to say about saccades that are influenced by object working memory. Results showed that memorized objects capture the eyes at nearly the same rate as abrupt onsets. When the abrupt onset and a memorized color coincide in the same object, this combination leads to even greater oculomotor capture. Finally, latencies support the competitive integration model: Shorter saccade latencies were found when the memorized color combined with the onset captured the eyes, as compared to either color or onset only. Longer latencies were also found when the color and onset occurred in the same display but were spatially separated.

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Ultra-Rapid Sensory Responses in the Human Frontal Eye Field Region

Cited by 93 publications

References 128 publications

Frequency-dependent spatiotemporal profiles of visual responses recorded with subdural ECoG electrodes in awake monkeys: Differences between high- and low-frequency activity

Frequency-dependent spatiotemporal profiles of visual responses recorded with subdural ECoG electrodes in awake monkeys: Differences between high- and low-frequency activity

The Dorsal Attention Network Mediates Orienting toward Behaviorally Relevant Stimuli in Spatial Neglect

The interaction between memorized objects and abrupt onsets in oculomotor capture

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