Shape optimization of pulsatile ventricular assist devices using FSI to minimize thrombotic risk

Long, Christopher C.; Marsden, Alison L.; Bazilevs, Yuri

doi:10.1007/s00466-013-0967-z

Cited by 110 publications

(61 citation statements)

References 58 publications

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“…To model the valve closure phase, the fluid viscosity in the region local to the valves was increased by 1e+4, resulting in a velocity of approximating zero through the "closed" valve. using the method similar to Long et al, 3 the afterload pressure at outlet was set to 80-120 mm Hg to mimic the output pressure fluctuation of pulsatile VAD. The preload at inlet was set to 10 mm Hg.…”

Section: Fsi Simulationmentioning

confidence: 99%

“…2 In light of pulsatile blood flow's benefit for myocardial recovery, perfusion of coronary arteries and end organs, pulsatile VADs are still widely used as paracorporeal mechanical circulatory support devices in clinical applications, especially in pediatric heart failure patients. [3][4][5] However, adverse events associated with VAD blood damage usually occur in clinical applications. [6][7][8] The blood damage of VADs includes not only hemolysis but also thrombosis.…”

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confidence: 99%

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The Influence of Different Operating Conditions on the Blood Damage of a Pulsatile Ventricular Assist Device

et al. 2015

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Because of pulsatile blood flow's benefit for myocardial recovery, perfusion of coronary arteries and end organs, pulsatile ventricular assist devices (VADs) are still widely used as paracorporeal mechanical circulatory support devices in clinical applications, especially in pediatric heart failure patients. However, severe blood damage limits the VAD's service period. Besides optimizing the VAD geometry to reduce blood damage, the blood damage may also be decreased by changing the operating conditions. In this article, a pulsatile VAD was used to investigate the influence of operating conditions on its blood damage, including hemolysis, platelet activation, and platelet deposition. Three motion profiles of pusher plate (sine, cosine, and polynomial), three stroke volumes (ejection fractions) (56 ml [70%], 42 ml [52.5%], and 28 ml [35%]), three pulsatile rates (75, 100, and 150 bpm), and two assist modes (copulsation and counterpulsation) were implemented respectively in VAD fluid-structure interaction simulations to calculate blood damage. The blood damage indices indicate that cosine motion profile, higher ejection fraction, higher pulsatile rate, and counterpulsation can decrease platelet deposition whereas increase hemolysis and platelet activation, and vice versa. The results suggest that different operating conditions have different effects on pulsatile VAD's blood damage and may be beneficial to choose suitable operating condition to reduce blood damage in clinical applications.

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Section: Fsi Simulationmentioning

confidence: 99%

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confidence: 99%

The Influence of Different Operating Conditions on the Blood Damage of a Pulsatile Ventricular Assist Device

et al. 2015

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“…Long residence times and areas of blood recirculation or stagnation may lead to increased risk of thrombosis in PVADs [169]. A method for calculating particle residence time for flows in moving spatial domains was proposed in [170], and the developments for PVAD FSI and residence time computations were used to perform a shape-optimization study of a paediatric device, as in [171]. The optimization using a derivative-free surrogate management framework (SMF) [172] was carried out for a full-scale three-dimensional device, with time-dependent FSI simulations performed under physiologically realistic conditions ( figure 17).…”

Section: Fluid -Structure Interaction Modelling Simulation and Optimmentioning

confidence: 99%

USNCTAM perspectives on mechanics in medicine

Bao

Bazilevs

Chung

et al. 2014

J. R. Soc. Interface.

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Over decades, the theoretical and applied mechanics community has developed sophisticated approaches for analysing the behaviour of complex engineering systems. Most of these approaches have targeted systems in the transportation, materials, defence and energy industries. Applying and further developing engineering approaches for understanding, predicting and modulating the response of complicated biomedical processes not only holds great promise in meeting societal needs, but also poses serious challenges. This report, prepared for the US National Committee on Theoretical and Applied Mechanics, aims to identify the most pressing challenges in biological sciences and medicine that can be tackled within the broad field of mechanics. This echoes and complements a number of national and international initiatives aiming at fostering interdisciplinary biomedical research. This report also comments on cultural/educational challenges. Specifically, this report focuses on three major thrusts in which we believe mechanics has and will continue to have a substantial impact. (i) Rationally engineering injectable nano/microdevices for imaging and therapy of disease. Within this context, we discuss nanoparticle carrier design, vascular transport and adhesion, endocytosis and tumour growth in response to therapy, as well as uncertainty quantification techniques to better connect models and experiments. (ii) Design of biomedical devices, including point-of-care diagnostic systems, model organ and multi-organ microdevices, and pulsatile ventricular assistant devices. (iii) Mechanics of cellular processes, including mechanosensing and mechanotransduction, improved characterization of cellular constitutive behaviour, and microfluidic systems for single-cell studies.

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“…In Ref. 75, the recently-developed residence time formulation was employed in the definition of the objective function for the FSI-based shape optimization study of a current PVAD design.…”

Section: Introductionmentioning

confidence: 99%

ST and ALE-VMS methods for patient-specific cardiovascular fluid mechanics modeling

Takizawa

Bazilevs

Tezduyar

et al. 2014

Math. Models Methods Appl. Sci.

113

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This paper provides a review of the space-time (ST) and Arbitrary Lagrangian-Eulerian (ALE) techniques developed by the first three authors' research teams for patientspecific cardiovascular fluid mechanics modeling, including fluid-structure interaction (FSI). The core methods are the ALE-based variational multiscale (ALE-VMS) method, the Deforming-Spatial-Domain/Stabilized ST formulation, and the stabilized ST FSI 2437 Math. Models Methods Appl. Sci. 2014.24:2437-2486. Downloaded from www.worldscientific.com by UNIVERSITY OF GEORGIA on 11/27/14. For personal use only. 2438 K. Takizawa et al.technique. A good number of special techniques targeting cardiovascular fluid mechanics have been developed to be used with the core methods. These include: (i) arterial-surface extraction and boundary condition techniques, (ii) techniques for using variable arterial wall thickness, (iii) methods for calculating an estimated zero-pressure arterial geometry, (iv) techniques for prestressing of the blood vessel wall, (v) mesh generation techniques for building layers of refined fluid mechanics mesh near the arterial walls, (vi) a special mapping technique for specifying the velocity profile at an inflow boundary with noncircular shape, (vii) a scaling technique for specifying a more realistic volumetric flow rate, (viii) techniques for the projection of fluid-structure interface stresses, (ix) a recipe for pre-FSI computations that improve the convergence of the FSI computations, (x) the Sequentially-Coupled Arterial FSI technique and its multiscale versions, (xi) techniques for calculation of the wall shear stress (WSS) and oscillatory shear index (OSI), (xii) methods for stent modeling and mesh generation, (xiii) methods for calculation of the particle residence time, and (xiv) methods for an estimated element-based zero-stress state for the artery. Here we provide an overview of the special techniques for WSS and OSI calculations, stent modeling and mesh generation, and calculation of the residence time with application to pulsatile ventricular assist device (PVAD). We provide references for some of the other special techniques. With results from earlier computations, we show how these core and special techniques work.

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Shape optimization of pulsatile ventricular assist devices using FSI to minimize thrombotic risk

Cited by 110 publications

References 58 publications

The Influence of Different Operating Conditions on the Blood Damage of a Pulsatile Ventricular Assist Device

The Influence of Different Operating Conditions on the Blood Damage of a Pulsatile Ventricular Assist Device

USNCTAM perspectives on mechanics in medicine

ST and ALE-VMS methods for patient-specific cardiovascular fluid mechanics modeling

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