Shape memory polymers and their composites in biomedical applications

Zhao, Wei; Liu, Liwu; Zhang, Fenghua; Leng, Jinsong; Liu, Yanju

doi:10.1016/j.msec.2018.12.054

Cited by 209 publications

(139 citation statements)

References 82 publications

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“…On the contrary, if the tying force is too weak, it may result in scars and even non-union. Therefore, the shape memory effect of this novel suture provides a potential therapeutic strategy that doctors could suture wounds in its slack elongated state, and then the suture would be triggered by body temperature to return to its original shape and the contraction of suture makes the knot tight in an adapted force (Zhao et al, 2019).…”

Section: In Vivo Shape Memorymentioning

confidence: 99%

Berberine-Incorporated Shape Memory Fiber Applied as a Novel Surgical Suture

et al. 2020

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The surgical suture has long been used to reconnect the injured tissues to restore their structure and function. However, its utility remains challenging in many areas, such as surgical site infections and minimally invasive surgeries. Herein, we report a novel surgical suture that possesses both antibacterial activity and shape memory effect to address these issues. In detail, natural antibacterial berberine was incorporated directly into the spinning solution of shape memory polyurethane with a near body transition temperature, and then berberine-containing polyurethane (BP) fibers were prepared by a facile one-step wetspinning method for surgical suture. The prepared BP fibers were micro-sized and characterized by their transition temperature, morphology, water contact angles, mechanical properties, in vitro shape memory effect, drug release, and antibacterial activity. The results showed that with the increasing amount of the incorporated berberine, the transition temperatures of the fibers were not significantly affected, remains at near body temperature, while the contact angles of the fibers were significantly decreased and the mechanical properties of the fibers were significantly weakened. The optimized fiber was selected to evaluate the cytotoxicity and in vivo biocompatibility before in vivo shape memory effect and wound healing capacity in a mouse skin suture-wound model was tested. Besides the shape memory effect, it was demonstrated that the fiber is capable of antibacterial activity and anti-inflammatory effect, and promoting wound healing. The mechanism of the antibacterial activity and anti-inflammatory effect of the fiber was discussed. Overall, it is expected that by the berberine added to the fiber for surgical suture, it will be more popular and extend the utility of the sutures in a wide range of clinical applications.

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Section: In Vivo Shape Memorymentioning

confidence: 99%

Berberine-Incorporated Shape Memory Fiber Applied as a Novel Surgical Suture

et al. 2020

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“…As time progressed in the modern age, humans were not satisfied with the available materials as some desirable characteristics of products cannot be satisfied by monolithic materials. Beside the product characteristics, economic requirements and the drive for miniaturization are compelling factors that promoted the gradual transition from monolithic to composites (Tasdemir and Kiziltas, 2009;Sharma et al, 2018;Zhao et al, 2019;Panaitescu et al, 2019;Henning et al, 2019;Echeverria et al, 2019). The miniaturization movement objectively drove progress in composite development from macrocomposite fabrication to micro-composite development.…”

Section: Introductionmentioning

confidence: 99%

Optimisation of Water Absorption Parameters of Dual-Filler Filled Composites Using Taguchi and Moderated Taguchi Techniques

2019

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This work contributes two novel modified Taguchi techniques to the optimal parametric setting for minimum water absorption in epoxy composites. Taguchi method, using ASTM standards was applied with factors (initial weight, final weight, length, sample thickness and time of immersion) and four levels in the experimental design. The analysis of variance (ANOVA) evaluates the significance and individual contributions of the parameters. The optimal parametric setting was A1B4C3D4E1 (initial weight, 2.61 g; final weight, 2.69 g; length, 62.73 mm; thickness, 3.88 mm; time, 15.65 hrs). The ANOVA identifies time and length as dominant parameters (98.98 and 1.02 % contributions, respectively). Taguchi-Pareto analysis found only factor-level from the time and length parameters economical to optimality. The Taguchi-ABC analysis revealed the individual weights and contributions of the factor-level irrespective of its initial groupings. The new Taguchi techniques highlighted the importance of time and length of sample in obtaining minimum water absorption of composites.

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“…The next important milestone in the development of SMPs is the application of heat shrinkable tubes and heat shrinkable films in the 1960s [11][12][13][14]. Nowadays, after decades of development, SMPs have been successfully used in many fields, such as aerospace [15][16][17][18], biomedical [19][20][21][22][23], and smart appliances [24]. Compared with shape memory alloys (SMAs) and shape memory ceramics (SMCs), SMPs have the advantages of lower density, higher strain (up to 800% [25]), excellent processability, good chemical stability, biocompatibility [20,22], and an adjustable biodegradation rate [26].…”

Section: Introductionmentioning

confidence: 99%

Effect of PEW and CS on the Thermal, Mechanical, and Shape Memory Properties of UHMWPE

et al. 2020

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Modified ultra-high-molecular-weight polyethylene (UHMWPE) with calcium stearate (CS) and polyethylene wax (PEW) is a feasible method to improve the fluidity of materials because of the tense entanglement network formed by the extremely long molecular chains of UHMWPE, and a modified UHMWPE sheet was fabricated by compression molding technology. A Fourier-transform infrared spectroscopy test found that a new chemical bond was generated at 1097 cm−1 in the materials. Besides, further tests on the thermal, thermomechanical, mechanical, and shape memory properties of the samples were also conducted, which indicates that all properties are affected by the dimension and distribution of crystal regions. Moreover, the experimental results indicate that the addition of PEW and CS can effectively improve the mechanical properties. Additionally, the best comprehensive performance of the samples was obtained at the PEW content of 5 wt % and the CS content of 1 wt %. In addition, the effect of temperature on the shape memory properties of the samples was investigated, and the results indicate that the shape fixity ratio (Rf) and the shape recovery ratio (Rr) can reach 100% at 115 °C and 79% at 100 °C, respectively, which can contribute to the development of UHMWPE-based shape memory polymers.

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Shape memory polymers and their composites in biomedical applications

Cited by 209 publications

References 82 publications

Berberine-Incorporated Shape Memory Fiber Applied as a Novel Surgical Suture

Berberine-Incorporated Shape Memory Fiber Applied as a Novel Surgical Suture

Optimisation of Water Absorption Parameters of Dual-Filler Filled Composites Using Taguchi and Moderated Taguchi Techniques

Effect of PEW and CS on the Thermal, Mechanical, and Shape Memory Properties of UHMWPE

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