Shape memory polymer foams for cerebral aneurysm reparation: Effects of plasma sterilization on physical properties and cytocompatibility

Nardo, Luigi De; Alberti, R; Cigada, A.; Yahia, L’Hocine; Tanzi, Maria Cristina; Farè, Silvia

doi:10.1016/j.actbio.2008.11.017

Cited by 63 publications

(66 citation statements)

References 28 publications

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“…Since, the three-dimensional (3D) scaffolds are designed for cell growth within their entire volume, they possess unique properties, such as relatively poor mechanical properties, very high porosity, and specific surface area, which provide the optimal condition for growing cells [3,4,5]. Proper choice of a sterilization method is especially difficult when the examined material must keep its thermally-induced shape memory properties.…”

Section: Introductionmentioning

confidence: 99%

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Influence of Radiation Sterilization on Properties of Biodegradable Lactide/Glycolide/Trimethylene Carbonate and Lactide/Glycolide/ε-caprolactone Porous Scaffolds with Shape Memory Behavior

et al. 2016

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The aim of the study was the evaluation of gamma irradiation and electron beams for sterilization of porous scaffolds with shape memory behavior obtained from biodegradable terpolymers: poly(l-lactide-co-glycolide-co-trimethylene carbonate) and poly(l-lactide-co-glycolide-co-ɛ-caprolactone). The impact of mentioned sterilization techniques on the structure of the scaffolds before and after the sterilization process using irradiation doses ranged from 10 to 25 kGy has been investigated. Treatment of the samples with gamma irradiation at 15 kGy dose resulted in considerable drop in glass transition temperature (Tg) and number average molecular weight (Mn). For comparison, after irradiation of the samples using an electron beam with the same dose, no significant changes in structure or properties of examined scaffolds have been noticed. Higher doses of irradiation via electron beam caused essential changes of the scaffolds’ pores resulting in partial melting of their surface. Nevertheless, obtained results have revealed that sterilization with electron beam, when compared to gamma irradiation, is a better method because it does not affect significantly the physicochemical properties of the scaffolds. Both used methods of sterilization did not influence the shape memory behavior of the examined materials.

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Section: Introductionmentioning

confidence: 99%

“…According to literature data, the vast majority of polymeric materials with shape memory behavior have been sterilized using a gas plasma sterilization process at room temperature [5,10,11]. However, in the case of this method, when used for sterilization of porous scaffolds, the increase in pore interconnection has been observed.…”

Section: Introductionmentioning

confidence: 99%

Influence of Radiation Sterilization on Properties of Biodegradable Lactide/Glycolide/Trimethylene Carbonate and Lactide/Glycolide/ε-caprolactone Porous Scaffolds with Shape Memory Behavior

et al. 2016

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“…Moreover, ion insertion in TiO 2 structure is also possible, providing that a suitable electrochemical bath is selected, although TiO 2 ion doping at low voltage anodization is actually a controversial issue (80, 81, 85, 86). Diffraction studies showed the oxide films material to be treated in a plasma under a high voltage bias (104)(105)(106). The term plasma is used to define a state of matter ("the fourth state of matter") characterized by the presence of a significant number of electrically charged or ionized atoms and/or molecules having the fundamental characteristic of exhibiting a collective behavior due to long-range Coulomb interactions (107).…”

Section: Anodic Oxidationmentioning

confidence: 99%

Titanium Oxide Antibacterial Surfaces in Biomedical Devices

et al. 2011

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Int J Artif Organs ( 2011; : 9) 929-946 34 TITANIUM OXIDE AND ANTIBACTERIAL SURFACES IN BIOMEDICAL DEVICES Device-related infections: a clinical demand driving material science researchAn increasing number of clinical procedures requires the use of biomedical devices, whose widespread presence in modern therapeutic treatments is driving the demand for better performances and longer reliability. One of the major issues of both short-term devices and implantable prostheses is represented by device-related infections (DRIs) Accepted: August 31, 2011 rEViEW due to bacterial colonization and proliferation (1). About half of the 2 million cases of nosocomial infections that occur each year in the United States are associated with indwelling devices (2): these infections generally require a longer period of antibiotic therapy and repeated surgical procedures, resulting in potential risks for the patient and increased costs for the healthcare system. The planktonic bacteria that colonize a device surface tend to form a biofilm and the sessile bacterial cells, enclosed in a self-produced polymeric matrix of this kind, can withstand host immune responses and generally show extraordinary antibiotic resistance (3). Eventually, bacteria rapid multiply and disperse in planktonic form, giving rise

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“…[18] Therapeutic embolization entails deliberately blocking a blood vessel (e.g., clipping an aneurysm to prevent internal bleeding, or reducing/stopping blood flow to tumors), and body temperature-responsive poly(ether urethane) SMP-based foams have been shown to be cytocompatible and enable the infiltration of mouse L929 fibroblast cells in vitro which is promising for potential future applications as aneurysm fillers in vivo. [19] Different temperature-responsive polyurethane SMPs that responded to temperature by expanding up to 70 times their original volume were shown to be relatively non-immunogenic in vitro [20] and after 90 days of implantation of radio-opaque analogues in a pig aneurysm model these materials showed low inflammation and good healing responses. [21] 3.…”

Section: Research Newsmentioning

confidence: 99%

Responsive Biomaterials: Advances in Materials Based on Shape‐Memory Polymers

et al. 2016

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Shape-memory polymers (SMPs) are morphologically responsive materials with potential for a variety of biomedical applications, particularly as devices for minimally invasive surgery and the delivery of therapeutics and cells for tissue engineering. A brief introduction to SMPs is followed by a discussion of the current progress toward the development of SMP-based biomaterials for clinically relevant biomedical applications.

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Shape memory polymer foams for cerebral aneurysm reparation: Effects of plasma sterilization on physical properties and cytocompatibility

Cited by 63 publications

References 28 publications

Influence of Radiation Sterilization on Properties of Biodegradable Lactide/Glycolide/Trimethylene Carbonate and Lactide/Glycolide/ε-caprolactone Porous Scaffolds with Shape Memory Behavior

Influence of Radiation Sterilization on Properties of Biodegradable Lactide/Glycolide/Trimethylene Carbonate and Lactide/Glycolide/ε-caprolactone Porous Scaffolds with Shape Memory Behavior

Titanium Oxide Antibacterial Surfaces in Biomedical Devices

Responsive Biomaterials: Advances in Materials Based on Shape‐Memory Polymers

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