Shape Memory Behavior of Novel (<scp>l</scp>-Lactide−Glycolide−Trimethylene Carbonate) Terpolymers

Zini, Elisa; Scandola, Mariastella; Dobrzyński, P.; Kasperczyk, Janusz; Bero, Maciej

doi:10.1021/bm700773s

Cited by 90 publications

(94 citation statements)

References 26 publications

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“…Biodegradable G-Cap and G-Cap-L polymers releasing ciprofloxacin were synthesized in the Center of Polymer and Carbon Materials of the Polish Academy of Sciences in Zabrze. Polymers were obtained by ring opening polymerization using non-toxic coordination initiator zirconium acetylacetonate Zr(acac) 4 [6,23]. Biodegradable polymeric coatings of G-Cap and G-Cap-L type were applied to metal implants by dip coating.…”

Section: Methodsmentioning

confidence: 99%

Corrosion resistance of Ti6Al4V alloy coated with caprolactone-based biodegradable polymeric coatings

Kajzer¹,

Jaworska²,

Jelonek³

et al. 2018

Eksploatacja i Niezawodność – Maintenance and Reliability

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The aim of this study was to determine the influence of long-term exposure of Ringer’s solution on degradation of the anodically oxidated Ti6Al4V alloy coated with a biodegradable polymer coating. Polymeric coatings made of poly(glycolide-ε-caprolactone) – G-Cap and poly(glycolide- ε-caprolactone-lactide) – G-Cap-L were applied by a dip-coating method. Degradation was assessed on the basis of the results of pitting corrosion resistance and density of metal ions infiltrating to the solution. Studies were conducted for samples after 3, 6, 8, 10 and 12 weeks of exposure to the corrosive environment. In addition, topography of the surface of the polymer coating was assessed. As a result of potentiodynamic studies, the value of the polarization resistance and corrosion potential for the G-Cap and G-Cap-L coated samples were significantly decreased while simultaneous reduction of the density of metal ions infiltrating to the solution throughout the whole study period. There was also observed a faster degradation of the G-Cap coating compared to G-Cap-L, which showed local discontinuity after 12 weeks of exposure. The obtained results provide the basis for the development of polymeric coatings on surface of metal implants with predictable time / kinetics of degradation by selecting the composition of polymers while simultaneous limitation of metal ions infiltration into surrounding tissues.

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Section: Methodsmentioning

confidence: 99%

Corrosion resistance of Ti6Al4V alloy coated with caprolactone-based biodegradable polymeric coatings

Kajzer¹,

Jaworska²,

Jelonek³

et al. 2018

Eksploatacja i Niezawodność – Maintenance and Reliability

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“…As T trans (= 37°C)>T g (= 22°C) was used for shaping (elongation to 150%), and fixing occurred T = 0°C [15]. Several works were devoted to synthesize terpolymers composed of trimethylene carbonate, L-lactide and glycolide (PTMC-LLA-GA) [16].…”

Section: Molecular Structure 211 T G -Based Systemsmentioning

confidence: 99%

Biodegradable polyester-based shape memory polymers: Concepts of (supra)molecular architecturing

Karger‐Kocsis

Kéki

2014

Express Polym. Lett.

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Shape memory (SM) biodegradable polymers (SMPs) and related composites are emerging smart materials in different applications. SMPs may adopt one (dual-shape), two (triple-shape) or several (multishape) stable temporary shapes and recover their permanent shape (or other temporary shapes in case of multi-shape versions) upon the action of an external stimulus. The external stimulus may be temperature, pH, water, light irradiation, redox condition etc. In most cases, however, the SMPs are thermally activated. The 'switching' or transformation temperature (T trans ), enabling the material to return to its permanent shape, is either linked with the glass transition (T g ) or with the melting temperature (T m ).Thus, SMPs are often subdivided based on their switch types into T g -or T m -based SMPs. As reversible 'switches' other mechanisms such as liquid crystallization and related transitions, supermolecular assembly/disassembly, irradiation-induced reversible network formation, formation and disruption of a percolation network, may also serve [1]. The permanent shape is guaranteed by physical or chemical network structures. The latter may be both on molecular and supramolecular levels. Linkages of these networks are termed net points. The temporary shape is created by mechanical deformation above T trans . In some cases the deformation temperature may be below Abstract. Shape memory polymers (SMPs) are capable of memorizing one or more temporary shapes and recovering to the permanent shape upon an external stimulus that is usually heat. Biodegradable polymers are an emerging family within the SMPs. This minireview delivers an overlook on actual concepts of molecular and supramolecular architectures which are followed to tailor the shape memory (SM) properties of biodegradable polyesters. Because the underlying switching mechanisms of SM actions is either related to the glass transition (T g ) or melting temperatures (T m ), the related SMPs are classified as T g -or T m -activated ones. For fixing of the permanent shape various physical and chemical networks serve, which were also introduced and discussed. Beside of the structure developments in one-way, also those in two-way SM polyesters were considered. Adjustment of the switching temperature to that of the human body, acceleration of the shape recovery, enhancement of the recovery stress, controlled degradation, and recycling aspects were concluded as main targets for the future development of SM systems with biodegradable polyesters.

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“…Consequently, they require harsh temperatures to fix temporary shape (<0°C) (3,(6)(7)(8) or trigger shape recovery (>70°C) that is often slow and incomplete (9)(10)(11). Moreover, few existing SMPs possess tunable biofunctionalizability and adequate mechanical strength at body temperature (12).…”

mentioning

confidence: 99%

High performance shape memory polymer networks based on rigid nanoparticle cores

Song

2010

Proc. Natl. Acad. Sci. U.S.A.

122

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Smart materials that can respond to external stimuli are of widespread interest in biomedical science. Thermal-responsive shape memory polymers, a class of intelligent materials that can be fixed at a temporary shape below their transition temperature (T trans ) and thermally triggered to resume their original shapes on demand, hold great potential as minimally invasive self-fitting tissue scaffolds or implants. The intrinsic mechanism for shape memory behavior of polymers is the freezing and activation of the long-range motion of polymer chain segments below and above T trans , respectively. Both T trans and the extent of polymer chain participation in effective elastic deformation and recovery are determined by the network composition and structure, which are also defining factors for their mechanical properties, degradability, and bioactivities. Such complexity has made it extremely challenging to achieve the ideal combination of a T trans slightly above physiological temperature, rapid and complete recovery, and suitable mechanical and biological properties for clinical applications. Here we report a shape memory polymer network constructed from a polyhedral oligomeric silsesquioxane nanoparticle core functionalized with eight polyester arms. The cross-linked networks comprising this macromer possessed a gigapascal-storage modulus at body temperature and a T trans between 42 and 48°C. The materials could stably hold their temporary shapes for >1 year at room temperature and achieve full shape recovery ≤51°C in a matter of seconds. Their versatile structures allowed for tunable biodegradability and biofunctionalizability. These materials have tremendous promise for tissue engineering applications.nanocompsite | shape memory materials | thermal responsive materials A thermal-responsive shape memory polymer (SMP) can be imparted with a "permanent" shape above a critical transition temperature (T trans ) when it is cast in a mold. For polymers, the T trans is either glass transition temperature T g or melting temperature T m . Such a permanent shape, formed at the elastic state of the material without external stress, is retained (memorized) as the SMP cools to a temperature below its T trans . The SMP can be deformed into a desired "temporary" shape by force at T > T trans , and this strained configuration can be fixed as the temperature cools below the T trans . When a thermal stimulus above the T trans is reapplied, however, the SMP recovers to its less strained permanent shape. This unique shape memory behavior has captured the imagination of the biomedical community as scientists strive to design smart implants and tissue scaffolds that can be delivered in a minimally invasive configuration and be subsequently reverted to a preprogrammed permanent shape in vivo.Since the first demonstration of degradable SMPs for potential tissue engineering applications (1, 2), many semicrystalline and amorphous polyester and polyurethane SMP networks have been reported. Adjustment of thermomechanical properties and degrad...

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Shape Memory Behavior of Novel (l-Lactide−Glycolide−Trimethylene Carbonate) Terpolymers

Cited by 90 publications

References 26 publications

Corrosion resistance of Ti6Al4V alloy coated with caprolactone-based biodegradable polymeric coatings

Corrosion resistance of Ti6Al4V alloy coated with caprolactone-based biodegradable polymeric coatings

Biodegradable polyester-based shape memory polymers: Concepts of (supra)molecular architecturing

High performance shape memory polymer networks based on rigid nanoparticle cores

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