between the boundary conditions and the long range orientational ordering in the bulk or long range distortions of the director field. [7,9,11] A spherical particle, immersed in an otherwise uniformly aligned nematic LC, introduces a hyperbolic point defect-hedgehog or a disclination loop when bearing vertical surface alignment of the director. [12][13][14] Arrays of spherical particles can generate disclination loops with knots and links, such as the Hopf link, the star of David, and the Borromean rings. [15][16][17][18][19] The topology of the generated disclinations can be further enriched by immersing particles with complex topologies into LCs, leading, for example, to two disclination loops around a torus particle or knotted disclination loops around a trefoil particle. [20][21][22][23][24] LCs with topological defects represent a promising medium for photonic applications, [25][26][27] for directing the self-assembly of particles with sizes from micrometers to nanometers, [15,[28][29][30][31][32][33] for programmable origami, [34,35] and for command of active matter. [36][37][38] Therefore, significant efforts have recently been dedicated to developing techniques for generating topological defects with designable structures. [39][40][41][42][43][44][45][46] For example, Yoshida and co-workers demonstrated suspended disclination loops by designing twist angle distribution [40,41] and 3D disclination networks by shifting defect patterns at the top and bottom surfaces. [42] Yokoyama et al. demonstrated stable webs of freestanding disclinations by using designed alignment patterns on two confining surfaces. [43] These studies demonstrate many appealing features of topological defects while triggering a question whether the approach can be further developed to enable more complex geometries of disclinations with preprogrammed features.In this work, we demonstrate the capability to precisely design and create complex 3D disclination networks, by using a recently developed plasmonic photopatterning technique to inscribe arbitrary 2D director patterns of LCs at two flat confining surfaces. [47,48] We present examples of precisely designed networks in which singular disclinations are either anchored to the substrates or remain freely suspended in bulk, forming polygonal loops or wavy curves. The type of the network is entirely determined by the designed director patterns at two confining surfaces of a flat nematic slab. We further demonstrate that the radius of curvature, size, and shape of these Linear defect-disclinations are of fundamental interest in understanding complex structures explored by soft matter physics, elementary particles physics, cosmology, and various branches of mathematics. These defects are also of practical importance in materials applications, such as programmable origami, directed colloidal assembly, and command of active matter. Here an effective engineering approach is demonstrated to pattern molecular orientations at two flat confining surfaces that produce complex yet designable network...