Shaofu Zhuyu Decoction Regresses Endometriotic Lesions in a Rat Model

Zhu, Guijin; Jiang, Chunhua; Yan, Xin; Zhao, Shu; Xu, Dingjie; Cao, Ying

doi:10.1155/2018/3927096

Cited by 10 publications

(8 citation statements)

References 39 publications

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“…However, according to the warning from the Herbal Pharmacopeia [ 39 ], leonuri Herba (Yi Mu Cao) and Shao-Fu-Zhu-Yu-Tang should be used with caution during pregnancy due to possible adverse effects such as increased contractile frequency and activity of the uterus [ 40 ]. We speculate that these herbs are likely to be used by older, highly educated women to treat infertility caused by dysmenorrhea and endometriosis disease [ 41 , 42 ]. Therefore, we recommend that TCM physicians should be cautious when prescribing CHM for pregnant women.…”

Section: Discussionmentioning

confidence: 99%

Prescription patterns and factors influencing the use of Chinese herbal medicine among pregnant women in Taiwan: a population-based retrospective study

Wen

Chang

Shen

et al. 2020

BMC Complement Med Ther

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Background The use of Chinese herbal medicine (CHM) has been widely promoted as a natural and safe way to treat illness during pregnancy. However, prescription patterns and factors influencing its use are largely unknown. Therefore, we conducted a population-based study to address these questions. Methods Pregnant women aged 18–50 years were selected from Taiwan’s National Health Insurance Research Database between 2001 to 2011. CHM prescriptions and diagnostic records were collected. Demographic data and pre-existing diseases were compared between CHM users and non-users. A multivariate logistic regression analysis was performed to identify possible factors influencing the use of CHM during pregnancy. Results A total of 81,873 eligible prescription records were identified, and 16,553 pregnant women were prescribed CHM during pregnancy, yielding a CHM prescription rate of 20.2%. The three most frequently used herbs were Scutellariae Radix (Huang Qin) (4.4%), Eucommiae cortex (Du Zhong) (2.5%), and Atractylodes Rhizome (Bai Zhu) (2.4%). The most frequently used herbal formulae were Dang-Guei-Shao-Yao-San (4.1%), Jia-Wei-Xiao-Yao-San (3.5%), and Xiang-Sha-Liu-Jun-Zi-Tang (2.6%). Multivariate logistic regression revealed that subjects with an older age, a university education, a pre-pregnancy history of CHM use, asthma, chronic renal disease, and cardiac valvular disease and living in a residential area other than northern Taiwan had an increase in adjusted odds ratio for CHM use during pregnancy. Conclusions In this population-based study, we found that demographic factors and pre-existing diseases were associated with the use of CHM among pregnant women. It is worth noting that Leonuri Herba (Yi Mu Cao) and Shao-Fu-Zhu-Yu-Tang should be used with caution in the first trimester. Further research is needed to explore the safety and effectiveness of the use of CHM in pregnant women.

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Section: Discussionmentioning

confidence: 99%

Prescription patterns and factors influencing the use of Chinese herbal medicine among pregnant women in Taiwan: a population-based retrospective study

Wen

Chang

Shen

et al. 2020

BMC Complement Med Ther

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“…Pentobarbital sodium and rabbit polyclonal antibody against cyclooxygenase-2 (ab15191; Abcam, UK) were purchased from Beijing Diweile Biotechnology Co., Ltd. e SFZYD contained 11 herbs: Foeniculi Fructus, Zingiberis Rhizoma, Corydalis Rhizoma, Myrrha, Rhizoma, Angelica Sinensis Radix, Radix Paeoniae Rubra, Cortex Cinnamomi, Typhae Pollen, and Trogopteri Feces. e origins, medicinal parts, and weight ratios of these herbs have been described in a previous article [18]. We created the formulation as follows.…”

Section: Chemicals and Reagentsmentioning

confidence: 99%

“…SFZYD is now widely used in TCM therapy for endometriosis. Our previous study showed that SFZYD inhibited cellular proliferation, promoted apoptosis, and reduced angiogenesis in ectopic endometrial tissues, thus playing a role in the treatment of endometriosis [ 18 ]. The purpose of the present study is to investigate our hypothesis that letrozole and SFZYD act on gut microbiota to inhibit the progression of lesions in rats with EMs.…”

Section: Introductionmentioning

confidence: 99%

Letrozole and the Traditional Chinese Medicine, Shaofu Zhuyu Decoction, Reduce Endometriotic Disease Progression in Rats: A Potential Role for Gut Microbiota

Cao

Jiang

Jia

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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We previously showed that the Chinese herbal medicine, Shaofu Zhuyu decoction (SFZYD), shrank the size of endometriotic lesions in rats with endometriosis. We therefore conducted the present study to investigate the effects of letrozole and SFZYD on gut microbiota in endometriotic rats. Rats were divided into four groups: a blank group, model group, letrozole group, and SFZY group. Ectopic lesion size and COX-2 expression in the endometrium and endometriotic lesions were compared, and the community of gut microbiota was detected using 16S rRNA gene sequencing. Both letrozole and SFZYD reduced the size of ectopic lesions as well as lowered the expression of COX-2, thus reducing the inflammatory response. Compared with the blank group, the α-diversity of gut microbiota in endometriotic rats decreased, the Firmicutes/Bacteroidetes ratio increased, and the abundance of Ruminococcaceae was reduced. The α-diversity of gut microbiota in the letrozole group was similar to that in the model group, but the Firmicutes/Bacteroidetes ratio was diminished. The α-diversity in the SFZY group was similar to that in the blank group, the Firmicutes/Bacteroidetes ratio was attenuated, and the abundance of Ruminococcaceae was elevated compared with the model group. These results indicated that the therapeutic mechanisms of both letrozole and SFZYD were related to the restoration of gut microbiota.

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“…Shaofu Zhuyu Decoction (SZD) consists of ten commonly used herbs and has been widely used in clinical practice to relieve symptoms of endometriosis. SZD significantly reduced the size of ectopic lesions inhibited cell proliferation, increased cell apoptosis, and reduced MVD, HIF-1 α and CD34 expression in the ectopic endometrium in a rat model [ 159 ].…”

Section: Resultsmentioning

confidence: 99%

Anti‐Angiogenic Alternative and Complementary Medicines for the Treatment of Endometriosis: A Review of Potential Molecular Mechanisms

Zheng

Cao²,

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Endometriosis is caused by the growth or infiltration of endometrial tissues outside of the endometrium and myometrium. Symptoms include pain and infertility. Surgery and hormonal therapy are widely used in Western medicine for the treatment of endometriosis; however, the side effects associated with this practice include disease recurrence and menopause, which can severely influence quality of life. Angiogenesis is the main biological mechanism underlying the development of endometriosis. Numerous natural products and Chinese medicines with potent anti-angiogenic effects have been investigated, and the molecular basis underlying their therapeutic effects in endometriosis has been explored. This review aims to describe natural products and compounds that suppress angiogenesis associated with endometriosis and to assess their diverse molecular mechanisms of action. Furthermore, this review provides a source of information relating to alternative and complementary therapeutic products that mediate anti-angiogenesis. An extensive review of the literature and electronic databases, such as the China National Knowledge Infrastructure, PubMed, and Embase, was conducted using the keywords ‘endometriosis,' ‘traditional Chinese medicine,' ‘Chinese herbal medicine,' ‘natural compounds,' and ‘anti-angiogenic' therapy. Anti-angiogenic therapy is an emerging strategy for the treatment of endometriosis. Natural anti-angiogenic products and Chinese medicines provide several beneficial clinical effects, including pain relief. In this review, we summarize clinical trials and experimental studies of endometriosis using natural products and Chinese medicines. In particular, we focus on anti-angiogenic products and alternative and complementary medicines for the treatment of endometriosis and additionally examine their therapeutic efficacy and mechanisms of action. Anti-angiogenic natural products and/or compounds provide a new approach for the treatment of endometriosis. Future work will require randomized trials with larger numbers of subjects, as well as long-term follow-up to confirm the findings described here.

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Shaofu Zhuyu Decoction Regresses Endometriotic Lesions in a Rat Model

Cited by 10 publications

References 39 publications

Prescription patterns and factors influencing the use of Chinese herbal medicine among pregnant women in Taiwan: a population-based retrospective study

Prescription patterns and factors influencing the use of Chinese herbal medicine among pregnant women in Taiwan: a population-based retrospective study

Letrozole and the Traditional Chinese Medicine, Shaofu Zhuyu Decoction, Reduce Endometriotic Disease Progression in Rats: A Potential Role for Gut Microbiota

Anti‐Angiogenic Alternative and Complementary Medicines for the Treatment of Endometriosis: A Review of Potential Molecular Mechanisms

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