Sexually dimorphic gene expression in mouse brain precedes gonadal differentiation

Dewing, Phoebe; Shi, Tao; Horvath, Steve; Vilain, Éric

doi:10.1016/s0169-328x(03)00339-5

Cited by 305 publications

(215 citation statements)

References 46 publications

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“…At this time in the mouse model system there is differential expression of 51 genes in the brains of XX versus XY embryos, most of which are autosomal (Dewing et al 2003). These data indicate that the XX/XY karyotype somehow influences (in trans) the expression of many genes during later embryo development (but before the testes start secreting T) in a manner that is independent of androgen signaling.…”

Section: Timing Of Xx/xy-induced Epi-marks That Canalize Sexual Develmentioning

confidence: 86%

Homosexuality as a Consequence of Epigenetically Canalized Sexual Development

Rice

Friberg²,

Gavrilets³

2012

The Quarterly Review of Biology

111

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Section: Timing Of Xx/xy-induced Epi-marks That Canalize Sexual Develmentioning

confidence: 86%

Homosexuality as a Consequence of Epigenetically Canalized Sexual Development

Rice

Friberg²,

Gavrilets³

2012

The Quarterly Review of Biology

111

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“…Indeed, the identification of genes differentially expressed in male and female mouse brains even before the formation of the gonads (at E10.5) suggests that genetic factors may also influence the sexual differentiation of the brain [9,10].…”

Section: Extent Of Global Sexual Dimorphismmentioning

confidence: 99%

Sexual dimorphism in environmental epigenetic programming

Gabory

Attig

Junien

2009

Molecular and Cellular Endocrinology

245

196

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The phenotype of an individual is the result of complex interactions between genotype and current, past and ancestral environment leading to a lifelong remodelling of our epigenomes. The vast majority of common diseases, including atherosclerosis, diabetes, osteoporosis, asthma, neuropsychological and autoimmune diseases, which often take root in early development, display some degree of sex bias, very marked in some cases. This bias could be explained by the role of sex chromosomes, the different regulatory pathways underlying sexual development of most organs and finally, lifelong fluctuating impact of sex hormones. A substantial proportion of dimorphic genes expression might be under the control of sex-specific epigenetic marks. Environmental factors such as social behaviour, nutrition or chemical compounds can influence, in a gender-related manner, these flexible epigenetic marks during particular spatiotemporal windows of life. Thus, finely tuned developmental program aspects, for each sex, may be more sensitive to specific environmental challenges, particularly during developmental programming and gametogenesis, but also throughout the individual's life under the influence of sex steroid hormones and/or sex chromosomes. An unfavourable programming could thus lead to various defects and different susceptibility to diseases between males and females. Recent studies suggest that this epigenetic programming could be sometimes transmitted to subsequent generations in a sex specific manner and lead to transgenerational effects (TGEs).This review summarizes the current understanding in the field of epigenetic programming and highlights the importance of studying both sexes in epidemiological protocols or dietary interventions both in humans and in experimental animal models.

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“…On sait également que les différences de développe-ment du cerveau et de comportement entre les mâles et les femelles, aux stades précédant la différenciation gonadique, résultent directement des profils d'expression sexuellement dimorphiques de gènes liés au déve-loppement neuronal. Au jour 10,5 du développement embryonnaire chez la souris, on peut détecter l'expression différentielle d'une cinquantaine de gènes, pour la plupart autosomiques, entre les cerveaux d'embryons mâles et femelles [13]. Dans leur très grande majorité, ces gènes interviennent dans trois catégories de fonctions biologiques : différenciation et prolifération cellulaires, régulation transcriptionnelle et signalisation.…”

Section: Stades Précoces Précédant La Différenciation Gonadiqueunclassified