Sexually dimorphic expression of multiple doublesex-related genes in the embryonic mouse gonad

Kim, Shinseog; Kettlewell, Jae R.; Anderson, Rebecca Cogwell; Bardwell, Vivian J.; Zarkower, David

doi:10.1016/s1567-133x(02)00071-6

Cited by 128 publications

(134 citation statements)

References 18 publications

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“…Besides medaka, there are no reports of other vertebrate species whose testes contain the sec-ond form of DMRT1. Thus, medaka is unique to have two forms of DMRT1 homolog genes in testes, although mice express several DM domain genes in the testis, including DMRT1, DMRT3, and DMRT4 (Kim et al, 2003). This study also showed that DMY protein localized in both the nuclei and cytoplasm of A-type spermatogonia-supporting Sertoli cells, although DMY is regarded as a transcriptional factor.…”

Section: Expression Of Dmrt1 During Testicular Developmentmentioning

confidence: 60%

Two DM domain genes, DMY and DMRT1, involved in testicular differentiation and development in the medaka, Oryzias latipes

Kobayashi

Matsuda

Kajiura-Kobayashi

et al. 2004

Developmental Dynamics

288

239

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The recent discovery of the DMY gene (DM domain gene on Y chromosome and one of the DMRT1 family genes) as a key determinant of male development in the medaka (Oryzias latipes) has led to its designation as the prime candidate gene for sex-determination in this species. This study focused on the sites and pattern of expression of DMY and DMRT1 genes during gonadal differentiation of medaka to further determine their roles in testis development. DMY mRNA and protein are expressed specifically in the somatic cells surrounding primordial germ cells (PGCs) in the early gonadal primordium, before morphological sex differences are seen. However, somatic cells surrounding PGCs never express DMY during the early migratory period. Expression of DMY persists in Sertoli cell lineage cells, from PGC-supporting cells to Sertoli cells, indicating that only DMY-positive cells enclose PGCs during mitotic arrest after hatching. DMRT1 is expressed in spermatogonium-supporting cells after testicular differentiation (20 -30 days after hatching), and its expression is much higher than that of DMY in mature testes. In XX sex-reversed testes, DMRT1 is expressed in the Sertoli cell lineage, similar to the expression of DMY in XY testes. These results suggest strongly that DMY regulates PGC proliferation and differentiation sex-specifically during early gonadal differentiation of XY individuals and that DMRT1 regulates spermatogonial differentiation. Developmental Dynamics 231:518 -526, 2004.

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Section: Expression Of Dmrt1 During Testicular Developmentmentioning

confidence: 60%

Two DM domain genes, DMY and DMRT1, involved in testicular differentiation and development in the medaka, Oryzias latipes

Kobayashi

Matsuda

Kajiura-Kobayashi

et al. 2004

Developmental Dynamics

288

239

View full text Add to dashboard Cite

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“…Some DM domain proteins are involved in the induction of sexual dimorphism in divergent invertebrates including flies and nematodes (Zarkower, 2002). DM domain genes other than dmrt1 have been identified in fish and mammals, and several of them might be involved in gonad development in the mouse (Brunner et al, 2001;Kondo et al, 2002;Kim et al, 2003;Winkler et al, 2004).…”

Section: Transposable Elements and Speciationmentioning

confidence: 99%

Genome evolution and biodiversity in teleost fish

2004

Heredity

592

430

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Teleost fish, which roughly make up half of the extant vertebrate species, exhibit an amazing level of biodiversity affecting their morphology, ecology and behaviour as well as many other aspects of their biology. This huge variability makes fish extremely attractive for the study of many biological questions, particularly of those related to evolution. New insights gained from different teleost species and sequencing projects have recently revealed several peculiar features of fish genomes that might have played a role in fish evolution and speciation. There is now substantial evidence that a round of tetraploidization/rediploidization has taken place during the early evolution of the ray-finned fish lineage, and that hundreds of duplicate pairs generated by this event have been maintained over hundreds of millions of years of evolution. Differential loss or subfunction partitioning of such gene duplicates might have been involved in the generation of fish variability. In contrast to mammalian genomes, teleost genomes also contain multiple families of active transposable elements, which might have played a role in speciation by affecting hybrid sterility and viability. Finally, the amazing diversity of sex determination systems and the plasticity of sex chromosomes observed in teleost might have been involved in both pre-and postmating reproductive isolation. Comparison of data generated by current and future genome projects as well as complementary studies in other species will allow one to approach the molecular and evolutionary mechanisms underlying genome diversity in fish, and will certainly significantly contribute to our understanding of gene evolution and function in humans and other vertebrates. Heredity (2005) 94, 280-294.

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“…In the mouse, functional redundancy may apply because several other DM domain genes have now been described, some of which are also expressed in the urogenital system. (72) Such redundancy could also occur in birds. Proof of a role for DMRT1 in the chicken embryo awaits experimental overexpression or knockdown (discussed below).…”

Section: Dmrt1 and The Z Dosage Hypothesismentioning

confidence: 99%

Sex determination: insights from the chicken

2004

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SummaryNot all vertebrates share the familiar system of XX:XY sex determination seen in mammals. In the chicken and other birds, sex is determined by a ZZ:ZW sex chromosome system. Gonadal development in the chicken has provided insights into the molecular genetics of vertebrate sex determination and how it has evolved. Such comparative studies show that vertebrate sex-determining pathways comprise both conserved and divergent elements. The chicken embryo resembles lower vertebrates in that estrogens play a central role in gonadal sex differentiation. However, several genes shown to be critical for mammalian sex determination are also expressed in the chicken, but their expression patterns differ, indicating functional plasticity. While the genetic trigger for sex determination in birds remains unknown, some promising candidate genes have recently emerged. The Z-linked gene, DMRT1, supports the Z-dosage model of avian sex determination. Two novel W-linked genes, ASW and FET1, represent candidate female determinants.

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Sexually dimorphic expression of multiple doublesex-related genes in the embryonic mouse gonad

Cited by 128 publications

References 18 publications

Two DM domain genes, DMY and DMRT1, involved in testicular differentiation and development in the medaka, Oryzias latipes

Two DM domain genes, DMY and DMRT1, involved in testicular differentiation and development in the medaka, Oryzias latipes

Genome evolution and biodiversity in teleost fish

Sex determination: insights from the chicken

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