Sexual transmission of hepatitis C virus: cohort study (1981-9) among European homosexual men.

Melbye, Mads; Biggar, Robert J.; Wantzin, Per; Krogsgaard, Kim; Ebbesen, Peter; Becker, Niels G.

doi:10.1136/bmj.301.6745.210

Cited by 141 publications

(39 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although multiple sexual partners cannot be protective against HCV infection, this finding is evidence against significant heterosexual transmission of hepatitis C. This agrees with some studies [17,18] whilst being contrary to others [19,20]. The risk for partners of men who have sex with men was based on small numbers, as would be expected in a blood donor population.…”

Section: Discussionsupporting

confidence: 85%

Risk factors for hepatitis C virus infection. A case-control study of blood donors in the Trent Region (UK)

et al. 1994

View full text Add to dashboard Cite

SUMMARYThe introduction of screening for hepatitis C virus (HCV) by the National Blood Transfusion Service identified donors who had acquired HCV infection. We undertook a case-control study amongst blood donors in the Trent Region to determine risks for HCV infection. A total of 74 blood donors confirmed positive for hepatitis C infection and 150 age, sex and donor venue matched controls were included in the study. Fifty-three percent of hepatitis C infected blood donors reported previous use of injected drugs compared to no controls; relative risk (RR) not estimatable (lower limit 95% CI = 20). Other risk factors were a history of: receipt of a blood transfusion or blood products RR = 3-6 (95% CI 15-8-3), having been a 'health care worker' RR = 2-8 (95% CI 1t 1-76), tattooing RR = 3 3 (95% CI 1-2-8-7), and an association with having been born abroad RR = 3 2 (95% CI 1-1-95). No risk was shown for a history of multiple sexual partners, ear piercing or acupuncture. Injecting drug use explains more than 50 % of hepatitis C infections in blood donors, a group who are less likely to have injected drugs than the general population.

show abstract

Section: Discussionsupporting

confidence: 85%

Risk factors for hepatitis C virus infection. A case-control study of blood donors in the Trent Region (UK)

et al. 1994

View full text Add to dashboard Cite

show abstract

“…similar to rates reported from Denmark (4.1%) (14). although a somewhat higher prevalence rate (8%) was reported from Spain (11).…”

Section: Discussionsupporting

confidence: 68%

Antibody to Hepatitis C Virus in Risk Groups in Canada

Chaudhary

Mo²

1991

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

RK CHAUDHARY, T Mo. Antibody to hepatitis C virus in risk groups in Canada. Can J Infect Dis 1992; 3(1):27-29. The prevalence of antibodies against hepatitis C virus (HCV] was studied in h emophiliacs, hemodialysis patients. intravenous drug abusers, female prisoners, homosexuals, individuals with no markers of recent hepatitis A orB virus infections and normal individuals (federal public servants). by an enzyme immunoassay (Orlho Diagnostic Systems Inc). Repeal positive samples were further tested by recombinant immunoblol assay (RIBA) HCV (Chi ron Corp. California). The number of samples positive for antibodies to HCV (anti-HCV] was higher witl1 enzyme immunoassay than by RJBA HCV in most cases. A high prevalence of anti-HCV was detected in hemophiliacs by both enzyme immunoassay (68.8%) and RJBA HCV (53.7% ). Among intravenous drug abusers and female prisoners the prevalence rates for anti-HCV were 42.8% and 29.8%, respectively. by RJBA HCV; the results with enzyme immunoassay were only slightly higher. The prevalence rate was also high by both tests (54.2% ) in hemodialysis patients' sera taken dming 1980-82. when many cases of non-A,non-B hepatitis were suspected in this group. In contrast. only 14.1% of sera tal

show abstract

“…10,11 In addition, other papers including studies relating HCV to patients with sexually transmitted diseases (STDs) 6'12 and to heterosexual activity with more than partner have been published. 13 Contrary to these findings, other investigations have suggested only rare sexual transmission of HCV among homosexuals 3 and among sexual contacts of high-risk intravenous (IV)-drug abusers. (Table 2).…”

contrasting

confidence: 43%

“…1,2 However, this type of transmission was recently estimated to account for as low as only 10-15% of patients with non-A, non-B hepatitis. 3 Recently, the isolation and cloning of a piece of DNA from non-A, non-B hepatitis virus and development of an assay for the antibody to hepatitis C virus (HCV) made possible the detection of many patients with a non-A, non-B hepatitis and the examination of transmission routes. 4'5 Recently, a 2nd-generation test for the detection of antibody vs. HCV was licensed.…”

mentioning

confidence: 99%

Prevalence of Hepatitis C Virus Antibody in Patients With Sexually Transmitted Diseases Attending a Harrisburg, PA, STD Clinic

Sautter

Jones

Weber

et al. 1994

Infectious Diseases in Obstetrics and Gynecology

View full text Add to dashboard Cite

Objective: The prevalence of hepatitis B and hepatitis C in a sexually transmitted disease (STD) clinic population was studied, along with the prevalence of various STD agents, in an attempt to identify possible STD markers for the hepatitis C virus and help delineate the role of hepatitis C as an STD. The hepatitis C antibody rates found in the STD clinic were also compared with those found among patients attending a local OB/GYN clinic and those enrolled in a blood donor program, all from the same geographical area.Methods: A total of 150 women attending an STD clinc were examined for each of the following agents: Chlamydia trachomatis, Neisseria gonorrhoeae, syphilis, hepatitis B surface antigen, hepatitis B core antibody, hepatitis B surface antibody, and hepatitis C virus antibody. Additionally, several patients who signed informed consent to be evaluated for human immunodeficiency virus (HIV) antibody were tested by an enzyme immunoassay (EIA) screen method. The prevalence of each agent was then compared with the other agents.Results: The overall prevalence rates detected were as follows: hepatitis B 16%, hepatitis C 4%, chlamydia 18.7%, gonorrhea 7.4%, syphilis 0.7%, and HIV 0%. Hepatitis C antibody was detected in 4% of patients in the STD clinic, 0.76% of volunteer blood donors from central Pennsylvania, and 0% of patients studied from the Harrisburg Hospital (Harrisburg, PA) prenatal population.Conclusions: This screening study reveals an association between attending a Harrisburg, PA, area STD clinic and having an increased prevalence of hepatitis C antibody, but larger matched control studies will be needed to help clarify sexual transmission as a mode of transmission for the hepatitis C virus. (C) Seven patients were found to be repeatedly reactive by the HCV EIA procedure. Six of the 7 (85.7%) reactive EIA specimens were found to be positive for antibody to HCV by the 2nd-generation HCV (EIA) procedure and by the RIBA. Of these 6 patients, 3 were also positive for hepatitis B core antibody. Of the subjects who were confirmed positive for HCV antibody, only (16%) had no risk factor as defined earlier. Three or 50% of the HCV-positive subjects had multiple risk factors with the most common risk factors being previous blood transfusion (50%), IV-drug abuse (33%), and multiple sexual partners (33%). No statistically significant associations were found for HCV-positive subjects and their risk factors. Other STDs were detected in those patients positive for HCV; however, no statistically significant association was determined. The overall prevalence of hepatitis C in 3 populations (STD, prenatal, and blood donor)

show abstract

Sexual transmission of hepatitis C virus: cohort study (1981-9) among European homosexual men.

Cited by 141 publications

References 12 publications

Risk factors for hepatitis C virus infection. A case-control study of blood donors in the Trent Region (UK)

Risk factors for hepatitis C virus infection. A case-control study of blood donors in the Trent Region (UK)

Antibody to Hepatitis C Virus in Risk Groups in Canada

Prevalence of Hepatitis C Virus Antibody in Patients With Sexually Transmitted Diseases Attending a Harrisburg, PA, STD Clinic

Contact Info

Product

Resources

About