Sexual Habits and Human Papillomavirus Infection Among Females in Three New Independent States of the Former Soviet Union

Syrjänen, Stina; Shabalova, Irena; Petrovichev, Nicolaj; Козаченко, В. П.; Zakharova, T.; Pajanidi, Julia; Podistov, Jurij; Chemeris, Galina; Sozaeva, Larisa; Lipova, Elena; Tsidaeva, Irena; Ivanchenko, Olga; Pshepurko, Alla; Zakharenko, Sergej; Nerovjna, Raisa; Kljukina, Ludmila; Erokhina, Oksana; Branovskaja, Marina; Ņikitina, Maritta; Grujnberga, Valerija; Grujnberg, Alexandr; Juschenko, Anna; Johansson, B. O.; Tosi, Piero; Cintorino, Marcella; Santopietro, Rosa; Syrjänen, Kari

doi:10.1097/01.olq.0000079519.04451.d4

Cited by 23 publications

(45 citation statements)

References 21 publications

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“…A cohort study of women at risks for HPV infection in three independent states of the former Soviet Union suggested an overall HPV prevalence of 33.4% [34]. Differences in the prevalence estimates within Russia may be partly explained by the disparity in the study populations.…”

Section: Discussionmentioning

confidence: 99%

Sociodemographic characteristics, sexual behaviour and knowledge about cervical cancer prevention as risk factors for high-risk human papillomavirus infection in Arkhangelsk, North-West Russia

Roik

Sharashova

Kharkova

et al. 2018

International Journal of Circumpolar Health

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While sociodemographic predictors of cervical cancer (CC) are well understood, predictors of high-risk (HR) human papillomavirus (HPV) infection have not been fully elucidated. This study explored the HR-HPV infection positivity in relation to sociodemographic, sexual behavior characteristics and knowledge about HPV and CC prevention among women who visited the Arkhangelsk clinical maternity hospital named after Samoylova, Russia. This cross-sectional study was conducted in the city of Arkhangelsk, Northwest Russia. Women who consulted a gynecologist for any reason between 1 January 2015 and 30 April 2015 were residents of Arkhangelsk, 25–65 years of age were included. The Mann–Whitney and Pearson’s χ2 tests were used. To determine the HR-HPV status, we used the Amplisens HPV-DNA test. We used a questionnaire to collect the information on sociodemographic factors. Logistic regression was applied. The prevalence of HR-HPV infection was 16.7% (n = 50). HR-HPV infection was more prevalent in younger women, cohabiting, nulliparae, smokers, having had over three sexual partners and early age of sexual debut. The odds of having a positive HR-HPV status increased by 25% with an annual decrease in the age of sexual debut. Moreover women with one child or more were less likely to have positive HR-HPV status.

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Section: Discussionmentioning

confidence: 99%

Sociodemographic characteristics, sexual behaviour and knowledge about cervical cancer prevention as risk factors for high-risk human papillomavirus infection in Arkhangelsk, North-West Russia

Roik

Sharashova

Kharkova

et al. 2018

International Journal of Circumpolar Health

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“…A multicenter trial in three New Independent States (NISs) of the former Soviet Union with a cohort of more than 3,000 women with different risks for HPV infections recently tested the performances of the Pap test, the HC2 assay, and PCR as screening tools (21)(22)(23). The present report compares the performance of the HC2 assay with that of the PCR for the detection of clinically significant cervical lesions (high-grade intraepithelial lesions [HSILs]) in these women.…”

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confidence: 99%

Human Papillomavirus Testing with the Hybrid Capture 2 Assay and PCR as Screening Tools

et al. 2004

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The recognition of high-risk human papillomaviruses (HPVs) as etiological agents of cervical cancer has increased the demands to use testing for HPV for the detection of abnormal cervical smears and for cervical cancer screening. The present study compared the performance of the Hybrid Capture 2 (HC2) assay with that of PCR for the detection of significant cervical lesions in 1,511 women with different risks for HPV infections in three New Independent States of the former Soviet Union. The results showed that the level of agreement between the HC2 assay and PCR was substantial, with a kappa (Cohen) value of 0.669 (95% confidence interval [CI], 0.629 to 0.709). Of the 228 samples with discrepant results, 92 were positive by the HC2 assay but negative by PCR, whereas 136 samples were PCR positive but HC2 assay negative. The positive predictive values (PPVs) of the HC2 assay and PCR in detecting high-grade intraepithelial lesions (HSILs) were 4.5% (95% CI, 3.5 to 5.5%) and 3.6% (95% CI, 2.7 to 4.5%), respectively, and the negative predictive values (NPVs) were 99.6% (95% CI, 99.3 to 99.9%) and 99.3% (95% CI, 98.9 to 99.7%), respectively. The sensitivities of the HC2 assay and PCR for the detection of HSILs were 85.2 and 74.0%, respectively, and the specificities were 67.2 and 64.1%, respectively. In receiver operating characteristic (ROC) analysis, the performance of the HC2 assay for the detection of HSILs was excellent (P ‫؍‬ 0.0001); the area under the ROC analysis curve was 0.858 (95% CI, 0.811 to 0.905), and the optimal balance between sensitivity (86.5%) and specificity (80%) was obtained with an HC2 assay cutoff level of 15.6 relative light units/positive control. Use of this cutoff would increase the specificity of the HC2 assay to 80.0% without compromising sensitivity. In conclusion, the results of PCR and the HC2 assay were concordant for 85% of samples, resulting in substantial reproducibility. Both tests had low PPVs, equal specificities, and equal (almost 100%) NPVs for the detection of HSILs; but the sensitivity of the HC2 assay was slightly better.Cervical carcinoma is the second most common malignancy in women worldwide. Infection with high-risk (HR) types of human papillomaviruses (HPVs) is the single most important risk factor for cervical cancer and its precursors (27,29). Screening for cervical cancer is traditionally based on Pap smear cytology, which suffers from subjectivity and which depends on the skills of the observer. The Pap test usually shows variable (poor to moderate) sensitivities (30 to 87%), and equivocal cases need to be repeated to improve diagnostics (4, 13). The recognition of HR HPVs as etiological agents of cervical cancer has increased the demands to use testing for HPV for the diagnosis of abnormal cervical smears (11) and even for screening for cervical cancer (9, 18). Testing for HPV has been shown to have higher sensitivities (84 to 100%) than the conventional Pap smear. Also, the negative predictive value (NPV) of testing for HPV DNA is very high; Clavel et al.(1) rep...

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“…The HPV interactions with p21 CIP1/WAF1/SDI1 have received some attention only recently (5,6,(44)(45)(46)(47)(48), and even less reports are available on cyclin A expression and its eventual prognostic value in cervical cancer (8,(49)(50)(51). Thus, it was of interest to elucidate how the differential expression of these cell cycle regulators relates to the different intermediate end point markers in cervical carcinogenesis based on immunohistochemical staining of the baseline biopsies from Pap smear -positive and/or HCII-positive women followed-up as part of the original New Independent States Cohort study (26)(27)(28)(29)(30)(31).…”

Section: Discussionmentioning

confidence: 99%

“…The concordance (intraclass correlation coefficient, weighted j) between the two raters was 0.758 [95% confidence interval (95% CI), 0.684-0.815]. Cervical lesions were graded using the CIN nomenclature, extended by the lowest category (HPV-NCIN), denoting lesions with HPV morphology but devoid of CIN (1,26,27 Follow-up and Viral Outcomes. All women who presented with low-grade lesions (HPV-NCIN or HPV-CIN1) were subjected to prospective follow-up, whereas high-grade lesions were promptly treated as detailed before (28)(29)(30)(31).…”

Section: Methodsmentioning

confidence: 99%

“…12 We recently conducted a cohort study testing 3,187 women for optional screening tools in three New Independent States of the Former Soviet Union, and f900 of these women were followed-up to assess the natural history of their HPV infections (the New Independent States cohort study; refs. 26,27). We also analyzed the temporal relationships between acquisition, persistence, and clearance of high-risk HPV and the clinical outcome of the lesions (28)(29)(30)(31).…”

Section: Introductionmentioning

confidence: 99%

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Cell Cycle Regulators p105, p107, Rb2/p130, E2F4, p21CIP1/WAF1, Cyclin A in Predicting Cervical Intraepithelial Neoplasia, High-Risk Human Papillomavirus Infections and Their Outcome in Women Screened in Three New Independent States of the Former Soviet Union

Santopietro

Shabalova²,

Petrovichev³

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: The growth-controlling functions of the highrisk human papillomaviruses (HPV) depend on their ability to interact with several cellular proteins, including the key regulatory proteins of the cell cycle. We have examined the value of cell cycle regulatory proteins as predictors of the intermediate end point markers in cervical carcinogenesis: (a) grade of cervical intraepithelial neoplasia (CIN), (b) highrisk HPV type, (c) clearance/persistence of high-risk HPV, and (d) disease outcome in women participating in a multicenter follow-up study in three New Independent States countries. Methods: Totally, 232 biopsy samples tested high-risk HPVpositive and/or Papanicolaou smear -positive women were immunohistochemically stained for the following cell cycle markers: p105, p107, p130, E2F4, p21 CIP1/WAF1/SDI1 , cyclin A, and Ki-67. In addition, apoptotic index (AI) and mitotic index (MI) were determined in H&E-stained sections. Prospective follow-up data were available to disclose the clinical and virological outcome of the lesions.

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Sexual Habits and Human Papillomavirus Infection Among Females in Three New Independent States of the Former Soviet Union

Cited by 23 publications

References 21 publications

Sociodemographic characteristics, sexual behaviour and knowledge about cervical cancer prevention as risk factors for high-risk human papillomavirus infection in Arkhangelsk, North-West Russia

Sociodemographic characteristics, sexual behaviour and knowledge about cervical cancer prevention as risk factors for high-risk human papillomavirus infection in Arkhangelsk, North-West Russia

Human Papillomavirus Testing with the Hybrid Capture 2 Assay and PCR as Screening Tools

Cell Cycle Regulators p105, p107, Rb2/p130, E2F4, p21CIP1/WAF1, Cyclin A in Predicting Cervical Intraepithelial Neoplasia, High-Risk Human Papillomavirus Infections and Their Outcome in Women Screened in Three New Independent States of the Former Soviet Union

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