Sexual Dysfunction in Women With Type 1 Diabetes

Enzlin, Paul; Mathieu, Chantal; Bruel, Annick Van den; Bosteels, Jan; Vanderschueren, Dirk; Demyttenaere, Koen

doi:10.2337/diacare.25.4.672

Cited by 226 publications

(269 citation statements)

References 25 publications

(41 reference statements)

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“…43) Diabetes also results reproductive disorders that results male and female infertility. 1,2) The present work confirm the male reproductive disorders in diabetic state as proposed by others 44) along with protective effect of the formulated experimental drug, MTEC for recovery of diabetes and testicular dysfunctions noted in diabetic state. The aqueous-methanol (40 : 60) extract of the above plant parts used here exhibit most effective and performing results than other solvents used for extract preparation which has been noted by trial and error by our labora- tory.…”

Section: Discussionsupporting

confidence: 75%

Protection of Testicular Dysfunctions by MTEC, a Formulated Herbal Drug, in Streptozotocin Induced Diabetic Rat

Mallick

Mandal

Barik

et al. 2007

Biological & Pharmaceutical Bulletin

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Diabetes is associated with declining sexual function in both male 1) and female 2) individuals. In case of female, diabetic symptoms consistent with autonomic neuropathy associated with decreased subjective sexual arousal. 3) In recent study Erol et al. noted that women with type 2 diabetes experienced higher prevalence rates of sexual dysfunction when compared to non diabetic. 4) Approximately 80% of diabetic patients complained loss of libido, 60% had diminished clitoral sensitivity, 50% experienced organic dysfunction, 40% experienced vaginal discomfort, and 40% experienced vaginal dryness. 5) Type 1 diabetic women experienced higher prevalence of reduced vasocongestion and reduced vaginal lubrication to erotic stimuli. 6) Thus these clinical studies suggest that both type 1 and type 2 impede the sexual arousal responses in women.Male reproductive alterations have been widely reported in model animals and human with diabetes. 7) Streptozotocin induced diabetes in male rats resulted atrophy of sex organ, changes in histoarchitecture of ventral prostate, 8) diminution in sperm count, 8) along with low levels in plasma gonadotrophins 9,10) and testosterone. 11) The copulatory behavior of diabetic rat has been collapsed 12) along with low fertility in induced normal mating. 12) In human, diabetes is associated with erectile dysfunction 13,14) along with loss of libido 1,5) and abnormal morphology of sperm, low plasma levels of gonadotrophins and testosterone. 15) Though there are several reports about dysfunctions of the male reproductive activity in diabetic state but the data are confusing, and the exact role that insulin plays in the regulation of male reproductive function is still unclear.In traditional practice, medicinal plants are used in many countries to control diabetes mellitus. The National Centre for Complementary and Alternative Medicine, established in 1998 by the United States Government where development of herbal medicine is one of the important subjects of study. 16,17) Moreover the herbal drug is of first choice at present because plant drugs are to be less toxic and more free from side effect than synthetic one. 18) M. paradisiaca is a tree like herb belonging to the Musaceae family and different parts of the plant have medicinal value. 19,20) T. indica LINN is tree type of plant belonging to the Caesalpiniaceae family was used as a traditional medicine for the management of diabetes mellitus. 21) E. Jambolana is used as traditional medicine for the management of diabetes. 19) This plant is found all over India and belongs to the Myrtaceae family. Jambu bark cure hemorrhages, burning sensation, dysentery, diarrhea, diabetes, excessive thirst, dyspepsia, cough and asthma and is used in preparation of astringent decoction for gargles and washes. 20) Seeds are used for the treatment of diabetes. 20) Coccinia indica is under Cucurbitaceae family and has medicinal importance as observed earlier by others. 22) In our previous work we have reported the antidiabetic effect of some of these plant pa...

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Section: Discussionsupporting

confidence: 75%

Protection of Testicular Dysfunctions by MTEC, a Formulated Herbal Drug, in Streptozotocin Induced Diabetic Rat

Mallick

Mandal

Barik

et al. 2007

Biological & Pharmaceutical Bulletin

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“…Also for diabetes mellitus, which represents an important causes of ED in men, 60 the data about the prevalence of FSD are controversial. [61][62][63] We found 64 a negative relationship between body weight and sexual function in 52 women with abnormal values of FSFI (score p23) (Figure 2). We also showed that obesity affects several aspects of sexual function in otherwise healthy women with FSD, including arousal, lubrication, satisfaction and orgasm, but not desire and pain.…”

Section: Obesity Metabolic Syndrome and Female Sexual Functionmentioning

confidence: 99%

Obesity and sexual dysfunction, male and female

et al. 2008

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Obesity has become a worldwide public health problem of epidemic proportions, as it may decrease life expectancy by 7 years at the age of 40 years: excess bodyweight is now the sixth most important risk factor contributing to the overall burden of disease worldwide. Overweight and obesity may increase the risk of erectile dysfunction (ED) by 30-90% as compared with normal weight subjects. On the other hand, subjects with ED tend to be heavier and with a greater waist than subjects without ED, and also are more likely to be hypertensive and hypercholesterolemic. The metabolic syndrome, characterized by a clustering of risk factors associated with insulin resistance and abdominal obesity, associates with ED. Moreover, women with the metabolic syndrome have an increased prevalence of sexual dysfunctions as compared with matched control women. Lifestyle changes aimed at reducing body weight and increasing physical activity induce amelioration of both erectile and endothelial functions in obese men. Moreover, preliminary evidence suggests that a Mediterranean-style diet might be effective in ameliorating sexual function in women with the metabolic syndrome. Lifestyle changes, mainly focussing on regular physical activity and a healthy diet, are effective and safe ways to reduce cardiovascular diseases and premature mortality in all population groups; they may also prevent and treat sexual dysfunctions in both sexes.

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“…14 Also for diabetes mellitus, which represents an important causes of erectile dysfunction in men, 15 the data about the prevalence of FSD are controversial. 16,17 Our study design has several strengths and weaknesses. (1) We did a case-control study across a wide range of body weight and including both premenopausal and postmenopausal women; so, it was not limited by the more prevalent sexual dysfunction in menopause.…”

Section: Discussionmentioning

confidence: 99%

Association of body weight with sexual function in women

et al. 2007

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Sexual difficulties in women appear to be widespread in society; the relationship between female sexual function and obesity is unclear. This study aimed to investigate the relationship between body weight, the distribution of body fat and sexual function in women. Fifty-two, otherwise healthy women with abnormal values of female sexual function index (FSFI) score (p23) were compared with 66 control women (FSFI 423), matched for age and menopausal status. All women were free from diseases known to affect sexual function. FSFI strongly correlated with body mass index (BMI) (r ¼ -0.72, P ¼ 0.0001), but not with waist-to-hip ratio (r ¼ -0.09, P ¼ 0.48), in women with sexual dysfunction. Of the six sexual function parameters, desire and pain did not correlate with BMI, while arousal (r ¼ -0.75), lubrication (r ¼ -0.66), orgasm (r ¼ -0.56) and satisfaction (r ¼ -0.56, all Po0.001) did. FSFI score was significantly lower in overweight women as compared with normal weight women, while cholesterol and triglyceride levels were higher. On multivariate analysis, both age and BMI explained about 68% of FSFI variance, with a primacy of BMI over age (ratio 4:1). In conclusion, obesity affects several aspects of sexuality in otherwise healthy women with sexual dysfunction.

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Sexual Dysfunction in Women With Type 1 Diabetes

Cited by 226 publications

References 25 publications

Protection of Testicular Dysfunctions by MTEC, a Formulated Herbal Drug, in Streptozotocin Induced Diabetic Rat

Protection of Testicular Dysfunctions by MTEC, a Formulated Herbal Drug, in Streptozotocin Induced Diabetic Rat

Obesity and sexual dysfunction, male and female

Association of body weight with sexual function in women

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