Sexual dimorphism of physical activity on cognitive aging: Role of immune functioning

Casaletto, Kaitlin B.; Lindbergh, Cutter A.; Memel, Molly; Staffaroni, Adam M.; Elahi, Fanny M; Weiner‐Light, Sophia; You, Michelle; Fonseca, Corrina; Karydas, Anna; Jacobs, Emily G.; Dubal, Dena B.; Yaffe, Kristine; Kramer, Joel H.

doi:10.1016/j.bbi.2020.05.014

Cited by 17 publications

(16 citation statements)

References 81 publications

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“…Interestingly we found overexpressed in male players the T cell receptor also, which is an upstream component of the same pathways confirming the ability of physical exercise to significantly alters the immune system ( Nieman and Wentz, 2019 ). Our findings agree with previous epidemiological results showing that the women have a greater Illness risk during international competition events suggesting that immune activation may be a male-specific pathway through which exercise confers benefit ( Nieman and Wentz, 2019 ; Casaletto et al, 2020 ).…”

Section: Discussionsupporting

confidence: 93%

Modulation of Plasma Proteomic Profile by Regular Training in Male and Female Basketball Players: A Preliminary Study

et al. 2022

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Monitoring fatigue and recovery during training periods contributes to identifying the best training methods to achieve sports performance. To date, little is known about sex-related differences in sports adaptations. The aim of the present study is to identify sex-related sports adaptation proteins in female basketball players and male basketball players using proteomics approach on plasma samples withdrawn from athletes during in-season training period but far from a competition. A cohort of 20 professional basketball players, 10 female (BF) and 10 male (BM), and 20 sedentary male (10 CM) and female (10 CF) as control, of comparable age and BMI, were involved in this study. Protein profiles of plasma samples obtained from BM, BF, CM, and CF were analyzed by two-dimensional electrophoresis (2-DE). Differentially expressed proteins were identified by mass spectrometry. The computational 2-DE gel image analysis pointed out 33 differentially expressed protein spots (ANOVA p-value < 0.05) and differences between male and female basketball players are more evident among the players than controls. The expression profile of 54.5% of the total proteins is affected by sports activity. Furthermore, 14 proteins are differentially expressed in basket female players in comparison with their relative controls while seven are differentially expressed in basket male players in comparison with their controls. In conclusion, we identify in female athletes a reduction in proteins related to transcription regulation, most of these modulate chronic inflammation confirming the anti-inflammatory effect of regular training in female muscle metabolism. In male and female athletes, we found a decrease in Transthyretin involved in muscle homeostasis and regeneration and Dermcidin a stress-induced myokine linked to inflammatory and it will be interesting to fully understand the role of its different isoforms in male and female skeletal muscle contraction.

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Section: Discussionsupporting

confidence: 93%

Modulation of Plasma Proteomic Profile by Regular Training in Male and Female Basketball Players: A Preliminary Study

et al. 2022

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“…This differential association between physical activity and brain integrity in men vs women suggests the existence of partly distinct reserve mechanisms according to biological sex. Although the exact underliers of this remains to be tested, previous works suggest the implication of sex‐specific immune mechanisms, 22 sex hormones, 48 sex differences in neuroplasticity, dopaminergic, or cardiovascular activity ( 49 for review), by which physical activity might differently promote brain and cognitive health in men and women. Of note, although we found no differences in the average amount of physical activity reported by men and women, or when investigating more specifically the type of activity, we cannot rule out the possibility that the specific components and intensity of exercise differ between sexes.…”

Section: Discussionmentioning

confidence: 99%

Men and women show partly distinct effects of physical activity on brain integrity

Gonneaud

Moreau

Felisatti

et al. 2022

Alz & Dem Diag Ass & Dis Mo

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Introduction Physical inactivity and female sex are independently associated with increased Alzheimer's disease (AD) lifetime risk. This study investigates the possible interactions between sex and physical activity on neuroimaging biomarkers. Methods In 134 cognitively unimpaired older adults (≥65 years, 82 women) from the Age‐Well randomized controlled trial (baseline data), we investigated the association between physical activity and multimodal neuroimaging (gray matter volume, glucose metabolism, perfusion, and amyloid burden), and how sex modulates these associations. Results The anterior cingulate cortex volume was independently associated with sex and physical activity. Sex and physical activity interacted on perfusion and amyloid deposition in medial parietal regions, such that physical activity was related to perfusion only in women, and to amyloid burden only in men. Discussion Physical activity has both sex‐dependent and sex‐independent associations with brain integrity. Our findings highlight partly distinct reserve mechanisms in men and women, which might in turn influence their risk of AD. Highlights Sex and physical activity have been linked to Alzheimer's disease (AD) progression. The association of sex and physical activity with brain health is partly independent. Different reserve mechanisms exist in men and women.

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“…Most of the previous studies were performed exclusively in male rodents ( Villeda et al, 2014 ; Deczkowska et al, 2017 ; Horowitz et al, 2020 ; Smith et al, 2015 ). Sex-dimorphic cognitive decline has been reported with age in humans ( Casaletto et al, 2019 ; Casaletto et al, 2020 ; Jack et al, 2015 ) and rodents ( Davis et al, 2019 ; Davis et al, 2020 ). In the current study, we identified cognitive reversal with ISRIB administration in both male and female mice; taking the critical first steps towards studying sex-dimorphic age responses in the ISR.…”

Section: Discussionmentioning

confidence: 99%

Small molecule cognitive enhancer reverses age-related memory decline in mice

Krukowski

Nolan

Frias

et al. 2020

eLife

103

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With increased life expectancy age-associated cognitive decline becomes a growing concern, even in the absence of recognizable neurodegenerative disease. The integrated stress response (ISR) is activated during aging and contributes to age-related brain phenotypes. We demonstrate that treatment with the drug-like small-molecule ISR inhibitor ISRIB reverses ISR activation in the brain, as indicated by decreased levels of activating transcription factor 4 (ATF4) and phosphorylated eukaryotic translation initiation factor eIF2. Furthermore, ISRIB treatment reverses spatial memory deficits and ameliorates working memory in old mice. At the cellular level in the hippocampus, ISR inhibition i) rescues intrinsic neuronal electrophysiological properties, ii) restores spine density and iii) reduces immune profiles, specifically interferon and T cell-mediated responses. Thus, pharmacological interference with the ISR emerges as a promising intervention strategy for combating age-related cognitive decline in otherwise healthy individuals.

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Sexual dimorphism of physical activity on cognitive aging: Role of immune functioning

Cited by 17 publications

References 81 publications

Modulation of Plasma Proteomic Profile by Regular Training in Male and Female Basketball Players: A Preliminary Study

Modulation of Plasma Proteomic Profile by Regular Training in Male and Female Basketball Players: A Preliminary Study

Men and women show partly distinct effects of physical activity on brain integrity

Small molecule cognitive enhancer reverses age-related memory decline in mice

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