Men and women show partly distinct effects of physical activity on brain integrity

Gonneaud, Julie; Moreau, Ilana; Felisatti, Francesca; Arenaza‐Urquijo, Eider M.; Ourry, Valentin; Touron, Edelweiss; Sayette, Vincent de La; Vivien, Denis; Chételat, Gaël

doi:10.1002/dad2.12302

Cited by 3 publications

(5 citation statements)

References 65 publications

(110 reference statements)

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“…We observed that higher PA was associated with lower amyloid burden; however, in sensitivity analyses, we found that the statistical significance of this association was driven by few men. Nevertheless, this finding would correspond to a recent study that also reported a significant association between amyloid burden and PA in men but not in women 49 …”

Section: Discussionsupporting

confidence: 90%

“…Nevertheless, this finding would correspond to a recent study that also reported a significant association between amyloid burden and PA in men but not in women. 49 We want to address some caveats regarding the interpretation of our results. As with all cross-sectional studies, we cannot provide direct causal evidence for protective roles of the studied lifestyle-related factors.…”

Section: Discussionmentioning

confidence: 98%

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Lifestyle Affects Amyloid Burden and Cognition Differently in Men and Women

Bachmann

Roman

Buchmann

et al. 2022

Annals of Neurology

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Objective Evidence on associations of lifestyle factors with Alzheimer's pathology and cognition are ambiguous, potentially because they rarely addressed inter‐relationships of factors and sex effects. While considering these aspects, we examined the relationships of lifestyle factors with brain amyloid burden and cognition. Methods We studied 178 cognitively normal individuals (women, 49%; 65.0 [7.6] years) and 54 individuals with mild cognitive impairment (women, 35%; 71.3 [8.3] years) enrolled in a prospective study of volunteers who completed 18F‐Flutemetamol amyloid positron emission tomography. Using structural equation modeling, we examined associations between latent constructs representing metabolic/vascular risk, physical activity, and cognitive activity with global amyloid burden and cognitive performance. Furthermore, we investigated the influence of sex in this model. Results Overall, higher cognitive activity was associated with better cognitive performance and higher physical activity was associated with lower amyloid burden. The latter association was weakened to a nonsignificant level after excluding multivariate outliers. Examination of the moderating effect of sex in the model revealed an inverse association of metabolic/vascular risk with cognition in men, whereas in women metabolic/vascular risk trended toward increased amyloid burden. Furthermore, a significant inverse association between physical activity and amyloid burden was found only in men. Inheritance of an APOE4 allele was associated with higher amyloid burden only in women. Interpretation Sex modifies effects of certain lifestyle‐related factors on amyloid burden and cognition. Notably, our results suggest that the negative impact of metabolic/vascular risk influences the risk of cognitive decline and Alzheimer's disease through distinct paths in women and men. ANN NEUROL 2022;92:451–463

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 98%

Lifestyle Affects Amyloid Burden and Cognition Differently in Men and Women

Bachmann

Roman

Buchmann

et al. 2022

Annals of Neurology

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“…The vast majority of studies indicate that men have higher levels of physical activity than women, which may be due to different uses of the time available in the course of a day [33][34][35][36]. A nationwide study reported that, on average, men devote one hour and thirty-three minutes per day to sports, while women, on average, perform physical exercises for one hour and nineteen minutes per day.…”

Section: Of 22mentioning

confidence: 99%

“…Moreover, men's workouts tend to be characterized by higher intensity than those performed by women. As a result, men's higher physical activity, to a greater extent than women's, may be a factor in protecting their mental fitness [35,36].…”

Section: Of 22mentioning

confidence: 99%

“…This suggests that the conclusions of the empirical works published to date are inconclusive. The reported results vary depending on the region of Poland, as well as the part of world in which they're conducted [33][34][35][36][37], which at the same time suggests that they appear to be worth supplementing. The results of our own research will therefore allow us to determine whether, and possibly to what extent, the observations of other researchers reflect the situation of the people of Eastern Poland.…”

Section: Of 22mentioning

confidence: 99%

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The Structure of the Relationship between Physical Activity and Psychosocial Functioning of Women and Men during the COVID-19 Epidemic in Poland

Mazur

Bartoń

2022

IJERPH

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Since the coronavirus disease (COVID-19) pandemic is a serious crisis in many countries around the world, it is important to conduct empirical research aimed at identifying risks and factors protecting the functioning of people affected by it. For this reason, the goals of the present research were to determine the level of physical activity and the severity of symptoms characteristic of mental disorders, cognitive disorders and the quality of social functioning, as well as the structure of the relationship between physical activity and psychosocial functioning of 226 women and 226 men during the COVID-19 epidemic in Eastern Poland. The research was conducted using the IPAQ-SF Questionnaire, GHQ-28 Questionnaires, TUS Test-6/9 version, the original SFS Scale and a self-developed sociodemographic survey. The collected data indicate that women as compared to men show lower levels of weekly physical activity, walking, moderate activity, vigorous activity and quality of functioning in family relationships, but higher severity of mental health disorders, somatic symptoms, functional disorders, depressive symptoms, cognitive disorders, perceptual work disorders, attention deficits and higher quality of functioning in work relationships. On the other hand, the structural model indicates that physical activity, interacting with mental health disorders and cognitive disorders, is positively associated with the social functioning of the respondents, and gender is the moderator of the occurring dependencies. This suggests that physical activity adapted to the condition of health may be an important component of gender-individualized psychopreventive interventions.

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Associations of Physical Activity Engagement with Cerebral Amyloid-β and Tau from Midlife

Gonzales,

Kojis,

Spartano

et al. 2024

JAD

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Background: Higher midlife physical activity engagement has been associated with lower dementia risk in late life. However, the underlying mechanisms contributing to the protective effect remain unclear. Objective: The goal of the current study was to evaluate the associations of physical activity with cerebral amyloid-β (Aβ) and tau in a predominately middle-aged community-based cohort, as well as to explore whether the associations differ by sex or age. Methods: Participants from the Framingham Heart Study underwent 11C-Pittsburgh Compound B amyloid and 18F-Flortaucipir tau positron emission tomography (PET) imaging. Total physical activity levels were evaluated by self-report using the Physical Activity Index (PAI). Cross-sectional associations between total PAI with regional Aβ and tau PET retention were evaluated using linear regression models adjusted for demographic and cardiovascular risk factors. Interactions with sex and age group were examined and stratified analyses were performed when significant. FDR-correction for multiple comparisons was applied. Results: The sample included 354 participants (mean age 53±8 years, 51% female). Higher total PAI scores were associated with lower entorhinal cortex tau PET binding (β (SE) = –0.021(0.008), p = 0.049). There were significant interactions with sex. In men alone, total PAI inversely associated with entorhinal cortex (β (SE) = –0.035(0.009), p = 0.001), inferior temporal (β (SE) = –0.029(0.010), p = 0.012), and rhinal cortex tau(β (SE) = –0.033(0.010), p = 0.002). Conclusions: The results suggest that higher midlife physical activity engagement may confer resistance to tau pathology. However, the effects may vary based on sex, highlighting the importance of better understanding and tailoring lifestyle interventions to address sex disparities.

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Men and women show partly distinct effects of physical activity on brain integrity

Cited by 3 publications

References 65 publications

Lifestyle Affects Amyloid Burden and Cognition Differently in Men and Women

Lifestyle Affects Amyloid Burden and Cognition Differently in Men and Women

The Structure of the Relationship between Physical Activity and Psychosocial Functioning of Women and Men during the COVID-19 Epidemic in Poland

Associations of Physical Activity Engagement with Cerebral Amyloid-β and Tau from Midlife

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