Sexual dimorphism in relationships between of plasma creatinine and some neuro-endocrine parameters

Background. Earlier we found that effects of plasma nitrogenous metabolites as urea, creatinine, and bilirubin on neuro-endocrine parameters, as well as anxiety, are significantly different in men and women of different ages. The purpose of this study is to analyze the relationships between the plasma uric acid level and some psycho-neuro-endocrine parameters in the same cohort. Materials and Methods. The object of observation were almost healthy volunteers: 31 males (24÷69 y) and 30 females, from among them 18 postmenopausal (48÷76 y) and 12 of reproductive age (30÷45 y). In basal conditions we determined plasma levels of uric acid and adaptation hormones, estimated the severity of the trait and reactive anxiety, recorded the ongoing HRV and EEG. After 4 or 7 days, repeated testing was performed. Results. By uric acid regression models with stepwise exclusion, it was found that in men plasma uric acid downregulates the PSD of β-rhythm in P4 and δ-rhythm in others 4 loci, but upregulates the Asymmetry of δ-rhythm, variability of α-rhythm, PSD of θ-rhythm in P3 and O1 loci, Entropy of EEG in T4 as well as Testosterone plasma level. The measure of determination is 54,5%. In postmenopausal women, uricemia downregulates the Amplitude of β-rhythm and its PSD in 8 loci as well as sympathetic tone, but upregulates the PSD of HF and VLF bands HRV, Testosterone plasma level, PSD of θ-rhythm in F3 and O2 loci as well as the Laterality of δ-rhythm. The degree of determination of neuro-endocrine parameters is 94,4%. In women of reproductive age uricemia upregulates the Asymmetry and Amplitude of β-rhythm and its PSD in 6 loci, the Amplitude and Laterality of θ-rhythm and its PSD in F8 locus, as well as the PSD of α-rhythm in F8 locus. The degree of positive determination of EEGs parameters is 95,5%. Conclusion. Plasma uric acid has a modulating effect on neuro-endocrine parameters, but this effect is significantly different in men and women of different ages, which is due, apparently, to the influence of sex hormones on the expression of adenosine receptors in neurons.

Section: Introductionmentioning

confidence: 96%

Sexual dimorphism in relationships between of plasma uric acid and some psycho-neuro-endocrine parameters

Bombushkar

Корда

Żukow

et al. 2022

“…During the realization of the project "Physiological activity of uric acid", our group new data were obtained in favor of this assumption. In particular, the level of uric acid in the serum through the corresponding nuclei of the cortex, amygdala, brainstem and medulla upregulate sympathetic tone and downregulate vagal tone [3,4,5], that is, it acts similarly to caffeine. However, the fact we obtained about a weak, but still positive (r=0,22) relationship between changes in uricemia (the level of which is comparable to the concentrations of adenosine and theophylline in in vitro immune tests) and relative content of CD8 + T cells in the blood, that is, theophyllinesensitive, at first glance, contradicts the classical position.…”

Section: Introductionmentioning

confidence: 99%

Variants of the influence of endogenous uric acid on the blood level of theophylline-sensitive T-lymphocytes can be predicted without error

Popovych,

Gozhenko,

Bombushkar

et al. 2024

Background. During the implementation of the project "Physiological activity of uric acid", our group discovered three variants of relationships between changes in uricemia and blood level of theophylline-sensitive CD8+ T-lymphocytes. The aim of this study is to find out the possibility of predicting one or another variants based on the set of initial parameters (predictors) of the patient. Materials and methods. Under an observations were 34 males (23-70 years) and 10 females (33-76 years) with chronic pyelonephritis in the phase of remission. Testing was performed twice - on admission and after 7-10 days of standard balneotherapy on Truskavets Spa. The main object of the study was serum and urine levels of uric acid. Other metabolic, endocrine and immune parameters were determined in the same blood and urine samples. In addition, EEG and HRV was recorded almost synchronously. Results. As a result of discriminant analysis, 23 predictors were selected. Among them, 10 reflect the power spectral density of all 4 EEG rhythms, 2 – EEG entropy, autonomous reactivity, 2 – hormones, 4 – immunity, 2 – metabolism, and another 2 – Popovych’s leukocytary indices of Strain and Adaptation. Prediction accuracy is 100%. Conclusion. The uric acid molecule, as a structural analog of methylxanthines and adenosine, exerts effects on neurons, endocrinocytes, and immunocytes, presumably through their adenosine receptors. The nature of the interaction of uric acid and adenosine receptors of theophylline-sensitive CD8+ T-lymphocytes is determined by a certain biochemical and physiological situation.

“…During the implementation of the project "Physiological activity of uric acid" [13,44], our group discovered four variants of the combination of levels of uricemia and uricosuria in patients with chronic pyelonephritis in the remission phase, which are accompanied by characteristic constellations of parameters of the central [7] and autonomic [5] nervous, endocrine [5], and immune [18,19,54] systems, as well as the exchange of nitrogenous metabolites and electrolytes [13], the levels of which correlate with uricemia and/or uricosuria. Similar tests, with the exception of EEG, were conducted in an experiment on healthy rats [3,4,[14][15][16][17]43].…”

Section: Introductionmentioning

confidence: 99%

Uric acid, neuroendocrine-immune complex and metabolism: relationships

Popovych,

Bombushkar,

Żukow

et al. 2023

Background. During the implementation of the project "Physiological activity of uric acid", our group discovered four variants of the combination of levels of uricemia and uricosuria in patients with chronic pyelonephritis in the remission phase, which are accompanied by characteristic constellations of parameters of the central and autonomic nervous, endocrine, and immune systems, as well as the exchange of nitrogenous metabolites and electrolytes, the levels of which correlate with uricemia and/or uricosuria. The aim of this study is to clarify the relationship between parameters of uric acid exchange and neuroendocrine-immune complex as well as other metabolites. Materials and methods. Under an observations were 34 males (23-70 years) and 10 females (33-76 years) with chronic pyelonephritis in the phase of remission. The main object of the study was serum and urine levels of uric acid. Other metabolic, endocrine and immune parameters were determined in the same blood and urine samples. In addition, EEG and HRV was recorded almost synchronously. Results. Among all registered parameters, 28 were identified as characteristic of the four variants of uric acid metabolism. The discriminant model includes, in addition to uricosuria and uricemia by definition, 10 neuroendocrine, 5 immune, and 6 metabolic parameters, as well as bacteriuria, Bifidobacteria of feces, entropy of immunocytogram and Popovych’s leukocytogram strain index. According to the results of the canonical correlation analysis, it was established that balneotherapy-induced concomitant changes in uricosuria and uricemia positively determine changes in, first, the PSD of the theta-rhythm in the T3 locus and beta-rhythm in the O2 locus aa well as HRV-markers of vagal tone and sympatho-vagal balance; secondly – diuresis and excretion of urea, magnesium, sodium, phosphates, calcium, potassium and chloride, as well as calciumemia and magnesiumemia; thirdly – serum IgG and CIC. Instead, changes in cortisolemia and testosteroneemia as well as TNF-alpha and the intensity of Staph. aureus phagocytosis are subject to negative determination. In general, the rate of uric acid determination of the dynamics of the listed parameters of the body is 96%. Conclusion. The uric acid molecule, as a structural analog of methylxanthines and adenosine, exerts effects on neurons, endocrinocytes, and immunocytes, presumably through their adenosine receptors, and the metabolic effects of uric acid are the consequences of its neuro-endocrine effects.