Sexual dimorphism in immune cell responses following stroke

Liu, Jialing; Sato, Yuzo; Falcone-Juengert, Jaime; Kurisu, Kota; Shi, Jian; Yenari, Midori A.

doi:10.1016/j.nbd.2022.105836

Cited by 12 publications

(2 citation statements)

References 155 publications

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“…Neutrophil activation and migration-specific genes were both time- and sex-dependent; immediately following cardioembolic stroke, females exhibited differentially expressed genes, whereas males did not. In contrast, in experimental models of stroke, older males had increased brain neutrophil infiltration than their female counterparts of the same age [ 65 , 66 ]. Unfortunately, our literature search could not reveal any relationship between monocytes and sex.…”

Section: Discussionmentioning

confidence: 99%

Monocyte to HDL and Neutrophil to HDL Ratios as Potential Ischemic Stroke Prognostic Biomarkers

Gkantzios

Tsiptsios

Karapepera

et al. 2023

Neurology International

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Ischemic stroke (IS) exhibits significant heterogeneity in terms of etiology and pathophysiology. Several recent studies highlight the significance of inflammation in the onset and progression of IS. White blood cell subtypes, such as neutrophils and monocytes, participate in the inflammatory response in various ways. On the other hand, high-density lipoproteins (HDL) exhibit substantial anti-inflammatory and antioxidant actions. Consequently, novel inflammatory blood biomarkers have emerged, such as neutrophil to HDL ratio (NHR) and monocyte to HDL ratio (MHR). Literature research of two databases (MEDLINE and Scopus) was conducted to identify all relevant studies published between 1 January 2012 and 30 November 2022 dealing with NHR and MHR as biomarkers for IS prognosis. Only full-text articles published in the English language were included. Thirteen articles have been traced and are included in the present review. Our findings highlight the utility of NHR and MHR as novel stroke prognostic biomarkers, the widespread application, and the calculation of which, along with their inexpensive cost, make their clinical application extremely promising.

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Section: Discussionmentioning

confidence: 99%

Monocyte to HDL and Neutrophil to HDL Ratios as Potential Ischemic Stroke Prognostic Biomarkers

Gkantzios

Tsiptsios

Karapepera

et al. 2023

Neurology International

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“…Previous studies have reported sex differences in stroke pathology, especially relating to the immune response to stroke. Here we will highlight a few examples; however, we acknowledge this topic has previously been reviewed in depth by others (Ahnstedt and McCullough, 2019;Banerjee and McCullough, 2022;Liu et al, 2022;Tariq et al, 2023). McCullough and others found sex differences in pathways leading to cell death after middle cerebral artery occlusion (MCAO) in mice (McCullough et al, 2005).…”

Section: Pathophysiologymentioning

confidence: 99%

Acute brain injury and nanomedicine: sex as a biological variable

Simmons,

Mihalek,

Bimonte Nelson

et al. 2024

Front. Biomater. Sci.

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Sex as a biological variable has been recognized for decades to be a critical aspect of the drug development process, as differences in drug pharmacology and toxicity in female versus male subjects can drive the success or failure of new therapeutics. These concepts in development of traditional drug systems have only recently begun to be applied for advancing nanomedicine systems that are designed for drug delivery or imaging in the central nervous system (CNS). This review provides a comprehensive overview of the current state of two fields of research - nanomedicine and acute brain injury—centering on sex as a biological variable. We highlight areas of each field that provide foundational understanding of sex as a biological variable in nanomedicine, brain development, immune response, and pathophysiology of traumatic brain injury and stroke. We describe current knowledge on female versus male physiology as well as a growing number of empirical reports that directly address sex as a biological variable in these contexts. In sum, the data make clear two key observations. First, the manner in which sex affects nanomedicine distribution, toxicity, or efficacy is important, complex, and depends on the specific nanoparticle system under considerations; second, although field knowledge is accumulating to enable us to understand sex as a biological variable in the fields of nanomedicine and acute brain injury, there are critical gaps in knowledge that will need to be addressed. We anticipate that understanding sex as a biological variable in the development of nanomedicine systems to treat acute CNS injury will be an important determinant of their success.

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Armcx1 attenuates secondary brain injury in an experimental traumatic brain injury model in male mice by alleviating mitochondrial dysfunction and neuronal cell death

Wang

Liu

et al. 2023

Neurobiology of Disease

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Sexual dimorphism in immune cell responses following stroke

Cited by 12 publications

References 155 publications

Monocyte to HDL and Neutrophil to HDL Ratios as Potential Ischemic Stroke Prognostic Biomarkers

Monocyte to HDL and Neutrophil to HDL Ratios as Potential Ischemic Stroke Prognostic Biomarkers

Acute brain injury and nanomedicine: sex as a biological variable

Armcx1 attenuates secondary brain injury in an experimental traumatic brain injury model in male mice by alleviating mitochondrial dysfunction and neuronal cell death

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