Acute brain injury and nanomedicine: sex as a biological variable
Amberlyn Simmons,
Olivia Mihalek,
Heather A. Bimonte Nelson
et al.
Abstract:Sex as a biological variable has been recognized for decades to be a critical aspect of the drug development process, as differences in drug pharmacology and toxicity in female versus male subjects can drive the success or failure of new therapeutics. These concepts in development of traditional drug systems have only recently begun to be applied for advancing nanomedicine systems that are designed for drug delivery or imaging in the central nervous system (CNS). This review provides a comprehensive overview o… Show more
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