Sexual dimorphism in corpus callosum and schizophrenia

Lewine, Richard; Flashman, Laura A.; Gulley, Lawrence R.; Beardsley, Scott; Wasserman, Amy; Lucas, Marsha; Risch, S. Craig

doi:10.1016/0920-9964(91)90012-g

Cited by 9 publications

(2 citation statements)

References 12 publications

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“…Males have an earlier age at onset (Lewine et al, 1991), more severe negative symptoms (Castle and Murray, 1991), higher incidence of maternal obstetric complications as a risk factor (Pearlson et al, 1985), and poorer response to antipsychotic treatment (Seeman, 1986). Women have a second peak of incidence during their late 40s to mid-50s (Kenna et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Prenatal Stress Induces Schizophrenia-Like Alterations of Serotonin 2A and Metabotropic Glutamate 2 Receptors in the Adult Offspring: Role of Maternal Immune System

Holloway¹,

Moreno²,

Umali³

et al. 2013

J. Neurosci.

113

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It has been suggested that severe adverse life events during pregnancy increase the risk of schizophrenia in the offspring. The serotonin 5-HT2A and the metabotropic glutamate 2 (mGlu2) receptors both have been the target of considerable attention regarding schizophrenia and antipsychotic drug development. We tested the effects of maternal variable stress during pregnancy on expression and behavioral function of these two receptors in mice. Prenatal stress increased 5-HT2A and decreased mGlu2 expression in frontal cortex, a brain region involved in perception, cognition and mood. This pattern of expression of 5-HT2A and mGlu2 receptors was consistent with behavioral alterations, including increased head-twitch response to the hallucinogenic 5-HT2A agonist DOI, and decreased mGlu2-dependent antipsychotic-like effect of the mGlu2/3 agonist LY379268 in adult, but not prepubertal, mice born to stressed mothers during pregnancy. Cross-fostering studies determined that these alterations were not due to effects of prenatal stress on maternal care. Additionally, a similar pattern of biochemical and behavioral changes were observed in mice born to mothers injected with poly-(I:C) during pregnancy as a model of prenatal immune activation. These data strengthen pathophysiological hypotheses that propose an early neurodevelopmental origin for schizophrenia and other psychiatric disorders.

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Section: Discussionmentioning

confidence: 99%

Prenatal Stress Induces Schizophrenia-Like Alterations of Serotonin 2A and Metabotropic Glutamate 2 Receptors in the Adult Offspring: Role of Maternal Immune System

Holloway¹,

Moreno²,

Umali³

et al. 2013

J. Neurosci.

113

View full text Add to dashboard Cite

show abstract

“…Recently, many researchers have focused on shape and size variations of the corpus callosum between distinct populations. There appears to be evidence confirming possible morphological differences between normal subjects and those subjects afflicted with schizophrenia (18,6,9), dyslexia (17) or Alzheimer's disease (16). If these effects are found to be distinctive enough we can hope to be able to use these differences in a diagnostic manner.…”

Section: Introductionmentioning

confidence: 96%

Sexual Dimorphism in the Corpus Callosum: A Characterization of Local Size Variations and a Classification Driven Approach to Morphometry

Pettey

Gee

2002

NeuroImage

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Sexual Dimorphism in the Corpus Callosum: Methodological Considerations in MRI Morphometry

Bermudez

Zatorre

2001

NeuroImage

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Sexual dimorphism in corpus callosum and schizophrenia

Cited by 9 publications

References 12 publications

Prenatal Stress Induces Schizophrenia-Like Alterations of Serotonin 2A and Metabotropic Glutamate 2 Receptors in the Adult Offspring: Role of Maternal Immune System

Prenatal Stress Induces Schizophrenia-Like Alterations of Serotonin 2A and Metabotropic Glutamate 2 Receptors in the Adult Offspring: Role of Maternal Immune System

Sexual Dimorphism in the Corpus Callosum: A Characterization of Local Size Variations and a Classification Driven Approach to Morphometry

Sexual Dimorphism in the Corpus Callosum: Methodological Considerations in MRI Morphometry

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