Sexual Characteristics Are Altered by 4-tert-Octylphenol and 17β-Estradiol in the Adult Male Guppy (Poecilia reticulata)

Toft, Gunnar; Baatrup, Erik

doi:10.1006/eesa.2000.1985

Cited by 68 publications

(35 citation statements)

References 57 publications

(59 reference statements)

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“…spermatogenesis occur in the Lake Apopka mosquitofish is presently under investigation. However, it is reasonable to assume that the lower sperm production is caused by endocrine disruption, because reduced sperm counts in poeciliid fishes have previously been observed in laboratory studies after exposure to EDCs such as 4-tert-octylphenol, bisphenol A, tributyltin, vinclozolin, and p,p´-DDE (Baatrup and Junge 2001;Bayley et al 2002;Haubruge et al 2000;Toft and Baatrup 2001). The endocrine control of sperm cell production in fish has not been described in detail, but it has been demonstrated in Japanese eel (Anguilla japonica) that chorionic gonadotropin or 11-ketotestosterone injections induce complete spermatogenesis (Miura et al 1991a(Miura et al , 1991b.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, poeciliids have several readily measurable sexual characteristics that are affected by exposure to chemicals with estrogenic or antiandrogenic activity (Baatrup and Junge 2001;Bayley et al 1999;Dreze et al 2000;Haubruge et al 2000;Toft and Baatrup 2001). Male mosquitofish have mature sperm cells in their testes year-round (Fraile et al 1992), and they have an extended reproductive period dependent on photoperiod and temperature (Fraile et al 1994;Koya et al 1998).…”

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confidence: 99%

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Disturbed sexual characteristics in male mosquitofish (Gambusia holbrooki) from a lake contaminated with endocrine disruptors.

Toft

Edwards

Baatrup

et al. 2003

Environ Health Perspect

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Previous laboratory studies have demonstrated that estrogenic and antiandrogenic chemicals can alter several sexual characteristics in male poeciliid fishes. Whether similar disturbances occur under field conditions remains to be confirmed. Lake Apopka, Florida, is contaminated with numerous chemicals, some of which possess endocrine-disrupting activity. Male mosquitofish (Gambusia holbrooki) were collected monthly from December 2000 through May 2001 from Lake Apopka and two nearby reference lakes, Orange Lake and Lake Woodruff National Wildlife Refuge. Selected sexual characteristics were compared temporally and among lakes during the collection period. Male fish from Lake Apopka had slightly shorter gonopodia and on average 32 and 47% fewer sperm cells per milligram testis, when compared with the fish collected from Orange Lake and Lake Woodruff, respectively. The testes weights increased markedly during spring, with significantly smaller testes in fish from Lake Apopka than from Orange Lake, but surprisingly, the smallest testes occurred in males obtained from the Lake Woodruff population. The highest liver weights were found in the Lake Apopka population. Whole-body concentrations of testosterone and estradiol varied among months; the peak testosterone concentration occurred in January and was significantly lower in male fish from Lake Apopka compared with Orange Lake. The intensity of male courtship behavior was highly correlated to body testosterone concentration, but no statistically significant differences in sexual behavior among the lakes were found. We conclude that sexual characteristics of relevance to male reproductive capacity are altered in the Lake Apopka mosquitofish population, and we discuss the presence of chemicals with antiandrogenic effects in Lake Apopka as a possible cause of the observed alterations.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Disturbed sexual characteristics in male mosquitofish (Gambusia holbrooki) from a lake contaminated with endocrine disruptors.

Toft

Edwards

Baatrup

et al. 2003

Environ Health Perspect

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“…In fish breeding, influencing the sex of fish by feeding high doses of sex hormones had been a common method to obtain monosex cultures [32]. Because sex differentiation differs not only between families but also within families, feminization by exposure to estrogenic compounds is not a common feature of fish, but has been observed in some fish species, such as roach (Rutilus rutilus) [35], medaka (O. latipes) [36], or guppies (Poecilia reticulata) [37].…”

Section: Fishmentioning

confidence: 99%

Endocrine disruptors in the environment (IUPAC Technical Report)

Lintelmann

Katayama

Kurihara

et al. 2003

Pure and Applied Chemistry

333

122

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Republication or reproduction of this report or its storage and/or dissemination by electronic means is permitted without the need for formal IUPAC permission on condition that an acknowledgment Endocrine disruptors in the environment (IUPAC Technical Report)Abstract: Many chemical substances of natural or anthropogenic origin are suspected or known to be endocrine disruptors, which can influence the endocrine system of life. This observation has led to increased interest on the part of the public and the media, as well as to a steep rise of research activities in the scientific community. New papers and results are presented so fast that it is impossible to give a complete review of this emerging research field. Therefore, this paper tries to give insight into some topics of the great scope of endocrine disruptors in the environment. To get a general idea of the biochemical and biological background, some parts of the endocrine systems of mammalians and nonmammalians are explained. The sections that follow describe important mechanisms of endocrine disruption such as interactions with hormone receptors. Test strategies for anthropogenic chemicals on various organisms are critically reviewed with respect to their problems and gaps concerning endocrine disruptors. The main emphasis of the paper is on the chemical substances suspected or known to be endocrine disruptors. To get a better comprehension of their behavior in the environment, physicochemical data such as water solubility or K ow , as well as information about their use and/or function are reviewed and compared. The main routes of exposure for most chemicals are shortly described, and data about concentrations in the environment (soil/sediment, water) are detailed.

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“…Subsequently, we assessed the effects of these three chemicals on the number of ejaculated sperm cells at the cellular level, body coloration, length of gonopodium (copulatory organ), and relative gonadal weight at the organ level, and finally courtship behavior at the organismal level. Previous studies have demonstrated that most of these end points are altered in adult male guppies exposed to the natural estrogen 17β-estradiol and the xenoestrogen 4-tert-octylphenol (31,35).…”

mentioning

confidence: 99%

“…The adult male has a bright orange coloration and performs a distinct courtship behavior. His anal fin is developed into a copulatory organ (the gonopodium) for internal fertilization, and ejaculates of sperm can be evacuated for sperm counting without harming the fish (30,31). The hormonal pathways controlling the expression of the male sexual characteristics are not fully understood, but sperm production, body coloration, and courtship behavior are known to be regulated by androgens (32)(33)(34).…”

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confidence: 99%

Antiandrogenic Pesticides Disrupt Sexual Characteristics in the Adult Male Guppy (Poecilia reticulata)

Baatrup¹,

Junge²

2001

Environmental Health Perspectives

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Sexual Characteristics Are Altered by 4-tert-Octylphenol and 17β-Estradiol in the Adult Male Guppy (Poecilia reticulata)

Cited by 68 publications

References 57 publications

Disturbed sexual characteristics in male mosquitofish (Gambusia holbrooki) from a lake contaminated with endocrine disruptors.

Disturbed sexual characteristics in male mosquitofish (Gambusia holbrooki) from a lake contaminated with endocrine disruptors.

Endocrine disruptors in the environment (IUPAC Technical Report)

Antiandrogenic Pesticides Disrupt Sexual Characteristics in the Adult Male Guppy (Poecilia reticulata)

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