Background: Nigeria has one of the highest maternal morbidity and mortality worldwide. Use of modern contraceptive has been shown to significantly reduce maternal morbidity and mortality. However, contraceptive use is still low among young women in Nigeria. This study was to determine the prevalence and determinants of contraceptive use among female undergraduates in Edo State.Methods: The study was a cross sectional study. 360 female undergraduates attending Irrua Specialist Teaching Hospital who met the eligibility criteria were consecutively recruited and questionnaire administered to them. The results were analysed using epi info 3.5.4 statistical software and significance level was set at p value less than 0.05.Results: The prevalence of contraceptive use among female undergraduates was found to be 28% despite 100% knowledge of contraception. Reasons for non-usage included fear of future infertility, refusal by male partner, fear of safety profile of the methods and lack of interest. Determinants of contraceptive use among the study population were older age (p = 0.02), being single (p = 0.04) and high socioeconomic status (p < 0.001).Conclusion: Contraceptive use is low among female undergraduates despite adequate knowledge due to fear of adverse effects and non-cooperation by male partner.Implication for Action: There is need for greater advocacy and education on the safety profile of modern contraception by policy makers, as well as educating men on the importance and benefits of contraception as their cooperation is key to increased usage.