Sex Steroid Regulation of Macrophage Migration Inhibitory Factor in Normal and Inflamed Colon in the Female Rat

Houdeau, Eric; Moriez, Raphaël; Lévêque, Mathilde; Salvador–Cartier, Christel; Waget, Aurélie; Leng, Lin; Buéno, Lionel; Bucala, Richard; Fioramonti, Jean

doi:10.1053/j.gastro.2006.12.028

Cited by 82 publications

(62 citation statements)

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“…Furthermore, we showed that neutrophil infiltration in the colon faced with inflammation was dramatically enhanced in female rats only. The latter correlated with an increase in the tissue levels of MIF, a stimulating factor of proinflammatory cytokines in acute colitis (28). It is noteworthy that, in contrast with the antiinflammatory effect of a direct NOAEL exposure in OVX rats, the same dose administered to pregnant and lactating mothers resulted in opposite effects in female offspring in adulthood.…”

Section: Discussionmentioning

confidence: 90%

“…Estrogens show antiinflammatory activity in the gut, decreasing the severity of colitis in animal models of human inflammatory bowel diseases (28). Similarly, we showed that BPA at NOAEL in OVX rats provides anti-inflammatory activity at the onset of inflammation, in reducing neutrophil infiltration and tissue level of MIF, a proinflammatory cytokine involved in the pathogenesis of inflammatory bowel disease known as a target for estrogen-mediated protection in the colon (28). Because the TDI BPA had no effect, these findings suggest that a daily BPA exposure does not represent a risk factor in developing inflammation in the adult female gut.…”

Section: Discussionmentioning

confidence: 99%

“…Altogether, a sex difference in intestinal permeability and inflammation (22), the prevalence of irritable bowel syndrome in women (23), the fluctuations of irritable bowel syndrome-associated abdominal pain in women during their menstrual cycle (24), as well as the wide expression of estrogen receptors (ERs) in human fetal and adult colonic mucosa (25,26) suggest that estrogens play a key role. In animal studies, estrogen action on intestinal permeability, inflammation, and viscerosensitivity are controlled by ERs in gut epithelial cells and sensory neurons, the latter conveying peripheral information to the central nervous system (27)(28)(29). Therefore, we assumed that BPA may target these receptors.…”

mentioning

confidence: 99%

“…In ovariectomized (OVX) rats exposed for 15 d to the NOAEL or the predicted safe dose TDI, we first examined colonic paracellular permeability under basal conditions (i.e., without inflammation), then inflammatory response through determination of neutrophil infiltration and colonic content of macrophage migration inhibitory factor (MIF), a proinflammatory cytokine targeted by estradiol in colitis (28). Second, we tested the hypothesis that daily oral exposure to BPA may impact pain perception in a model of visceral sensitivity in response to colorectal distension.…”

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confidence: 99%

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Impact of oral bisphenol A at reference doses on intestinal barrier function and sex differences after perinatal exposure in rats

Braniste¹,

Jouault²,

Gaultier³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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Bisphenol A (BPA), a chemical estrogen widely used in the foodpackaging industry and baby bottles, is recovered in human fluids (0.1-10 nM). Recent studies have reported that BPA is hormonally active at low doses, emphasizing the debate of a risk for human health. Estrogen receptors are expressed in the colon, and although the major route of BPA exposure is food, the effects on gut have received no attention. We first examined the endocrine disrupting potency of BPA on colonic paracellular permeability (CPP), experimental colitis, and visceral sensitivity in ovariectomized rats orally exposed to 5 mg/kg/d BPA (i.e., the no observed adverse effect level), 50 μg/kg/d BPA (i.e., tolerable daily intake), or lower doses. BPA dosedependently decreased basal CPP, with a half-maximal inhibitory dose of 5.2 μg/kg/d, 10-fold below the tolerable daily intake. This correlated with an increase in epithelial tight junction sealing, also observed in Caco-2 cells exposed to 10 nM BPA. When ovariectomized rats were fed with BPA at the no observed adverse effect level, the severity of colitis was reduced, whereas the same dose increased pain sensitivity to colorectal stimuli. We then examined the impact of perinatal exposure to BPA on intestinal permeability and inflammatory response in the offspring. In female rats, but not in male rats, perinatal BPA evoked a decrease of CPP in adulthood, whereas the proinflammatory response of colonic mucosa was strengthened. This study first demonstrates that the xenoestrogen BPA at reference doses influences intestinal barrier function and gut nociception. Moreover, perinatal exposure promotes the development of severe inflammation in adult female offspring only.endocrine disruptor | gut permeability | inflammation | pain | estrogen

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Impact of oral bisphenol A at reference doses on intestinal barrier function and sex differences after perinatal exposure in rats

Braniste¹,

Jouault²,

Gaultier³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

158

111

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“…In mouse models of estrogen-depletion, mimicking aging-related reductions of estrogen levels in women, MIF was found up-regulated in cutaneous wounds but functioned to attenuate wound healing [13,14]. Estrogen-mediated down-regulation of MIF and protection from MIF-dependent inflammatory processes was recently confirmed in a model of colon inflammation [30]. On the other hand, Abe and colleagues observed that an upregulation of MIF in skin wounds of rats was accompanied by an accelerating effect of MIF on the wound healing process of skin tissue [15].…”

Section: Discussionmentioning

confidence: 99%

Macrophage migration inhibitory factor (MIF) promotes fibroblast migration in scratch‐wounded monolayers in vitro

Dewor

Steffens²,

Krohn³

et al. 2007

FEBS Letters

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MIF was recently redefined as an inflammatory cytokine, which functions as a critical mediator of diseases such as septic shock, rheumatoid arthritis, atherosclerosis, and cancer. MIF also regulates wound healing processes. Given that fibroblast migration is a central event in wound healing and that MIF was recently demonstrated to promote leukocyte migration through an interaction with G-protein-coupled receptors, we investigated the effect of MIF on fibroblast migration in wounded monolayers in vitro. Transient but not permanent exposure of primary mouse or human fibroblasts with MIF significantly promoted wound closure, a response that encompassed both a proliferative and a pro-migratory component. Importantly, MIF-induced fibroblast activation was accompanied by an induction of calcium signalling, whereas chronic exposure with MIF down-regulated the calcium transient, suggesting receptor desensitization as the underlying mechanism.

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Double Jeopardy

Zenlea

Wolf

2013

Inflammatory Bowel Diseases

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Sex Steroid Regulation of Macrophage Migration Inhibitory Factor in Normal and Inflamed Colon in the Female Rat

Cited by 82 publications

References 59 publications

Impact of oral bisphenol A at reference doses on intestinal barrier function and sex differences after perinatal exposure in rats

Impact of oral bisphenol A at reference doses on intestinal barrier function and sex differences after perinatal exposure in rats

Macrophage migration inhibitory factor (MIF) promotes fibroblast migration in scratch‐wounded monolayers in vitro

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