Sex Steroid Hormone Pathway Genes and Health-Related Measures in Women of 4 Races/Ethnicities: The Study of Women’s Health Across the Nation (SWAN)

Sowers, Mary Fran; Wilson, Angela; Karvonen‐Gutierrez, Carrie; Kardia, Sharon R.

doi:10.1016/j.amjmed.2006.07.012

Cited by 43 publications

(42 citation statements)

References 24 publications

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“…The G and C alleles respectively have been associated with higher gene expression (Alonso et al, 2011), and increased serum estrogen levels Sowers et al, 2006), although not consistently (Malacara et al, 2004;Yaffe et al, 2009). In a similar manner, one or both alleles have also been associated with more favourable estrogen-dependent outcomes such as higher bone mass density and lower fractures (Ioannidis et al, 2002)), and a decreased risk of cognitive impairment (Yaffe et al, 2002), Alzheimer's disease (Monastero et al, 2006), phobia (Ryan et al, 2011b), general anxiety (Tiemeier et al, 2005) and cardiovascular disease .…”

Section: Discussionmentioning

confidence: 99%

“…Two ESR1 SNPs located at position 397 and 351 of intron 1 were examined, rs9340799 and rs2234693 respectively. These SNPs were chosen for because: 1/ they have shown potential causal associations with other estrogen-dependent health outcomes, including Alzheimer's disease (Corbo et al, 2006), cognitive function (Yaffe et al, 2002), cardiovascular disease (Herrington et al, 2002;Shearman et al, 2003), osteoporosis (Ioannidis et al, 2002), breast cancer (Kjaergaard et al, 2007;Slattery et al, 2007) and vasomotor symptoms (Malacara et al, 2004); 2/ we have previously demonstrated significant associations between these ESR1 polymorphisms and depressive symptoms in older women (Ryan et al, 2011a); 3/ there is evidence that these polymorphisms are functional as they regulate ESR1 expression (Alonso et al, 2011;Herrington et al, 2002;Maruyama et al, 2000) and have shown some association serum estradiol levels Sowers et al, 2006).…”

Section: Methodsmentioning

confidence: 99%

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Estrogen receptor alpha gene variants and major depressive episodes

Ryan

Scali

Carrière

et al. 2012

Journal of Affective Disorders

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Background: Despite evidence of estrogen's mood-enhancing effects, the association between estrogen receptor (ER) gene variants and lifetime major depression has been insufficiently studied.Methods: 3987 community-dwelling women aged 65 years and over were recruited in France as part of the Three City Study. Current and past major depressive disorders (MDD) were diagnosed using the Mini-International Neuropsychiatry Interview, according to DSM-IV criteria. The association between two common estrogen receptor alpha (ESR1) polymorphisms with lifetime MDD was examined using adjusted logistic regression models, taking into account the age at first depressive episode and the recurrence of depression.Results: Women homozygous for the variant G allele of ESR1 rs9340799 had a 1.6-fold increased risk of MDD across their lifetime compared with women who were homozygous for the A allele (p=0.009). There was a similar non-significant trend for the C allele of rs2234693 being associated with an increased risk (p=0.09). Polytomous regression analysis further indicated that the GG genotype of rs9340799 was specifically associated with an increased risk of recurrent depressive episodes, regardless of the age at first onset of depression relative to the menopause. Limitations:The duration and severity of depressive episodes was not considered in the analysis.Conclusions: This is the first study to examine the association between ESR1 gene variants and lifetime MDD. Our findings indicate a significant association between common variants and the risk of recurrent depressive episodes. This suggests that certain depressed women could be most responsive to hormone-based treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Estrogen receptor alpha gene variants and major depressive episodes

Ryan

Scali

Carrière

et al. 2012

Journal of Affective Disorders

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“…As sex hormones, DHEA-s, free testosterone and estradiol are deeply involved in reproductive activity, but start to fall after the peak between the 20s and 40s [18], [19], [20] . This decrease is particularly pronounced among females, and plays a part in menopause disorders, osteoporosis, loss of muscle volume, promotion of arteriosclerosis, and other conditions known as aging phenomena [20] .…”

Section: Discussionmentioning

confidence: 99%

“…This decrease is particularly pronounced among females, and plays a part in menopause disorders, osteoporosis, loss of muscle volume, promotion of arteriosclerosis, and other conditions known as aging phenomena [20] . Today, hormone replacement therapy is available in Japan under health insurance.…”

Section: Discussionmentioning

confidence: 99%

“…To discover the balance between these, we measured the urine concentration and production rate of 8-hydroxydeoxyguanosine (8-OHdG) [12] and isoprostanes (IPs) [13] as oxidation markers, and vitamin A [14] , vitamin B12 [15] and folic acid [16] as anti-oxidation factors opposing these. As serum hormones, we measured insulin-like growth factor (IGF-1) [17] , dehydroepiandrosterone sulfate (DHEA-s) [18], [19] , free testosterone in males [19] , estrogen in females [20] , free-thyroxine (T4) [21] and adiponectin [22], [23] . Besides these, we also measured blood pressure [22], [23] and cystatin C [24] .…”

Section: Study Items and Methodsmentioning

confidence: 99%

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A proposal research for new health check-up items focusing on the future super-aging society in Japan

Nishizaki

Kubo

Kuwahira

et al. 2011

HEP

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Longitudinal interplays of estrogen receptor alpha gene rs9340799 with social‐environmental factors on post‐traumatic stress disorder in Chinese Han adolescents after Wenchuan earthquake

Feng

Yan

et al. 2017

American J of Med Genetics Pt B

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Indirect evidences suggested associations of estrogen receptor alpha (ESR1) with post-traumatic stress disorder (PTSD). However, the relationship between rs9340799 on ESR1 gene and PTSD has not been reported yet. The present study was to explore the longitudinal changes of prevalence and severity of PTSD in adolescents with different genotypes of rs9340799 after the 2008 Wenchuan earthquake. Social-environmental factors were collected by questionnaires in 465 high school students. Variants of rs9340799 were determined by polymerase chain reaction-restriction fragment length polymorphism analyses and verified by DNA sequencing. PTSD symptoms were assessed by PTSD Checklist-Civilian Version (PCL-C) at 6, 12, and 18 months after the earthquake. The female AA homozygotes had a trend of higher prevalence of PTSD and significantly higher PCL-C scores than the female G allele carriers at 6 months after the earthquake. The female students had higher prevalence of PTSD and higher PCL-C scores than the male subjects at 6 months in the AA homozygotes, but not in the G allele carriers. Consecutive decreases in PCL-C scores were observed only in the female AA homozygotes. Only in the female, the AA genotype was the risk factor and predictor of PCL-C scores at 6 months. Potential factors of PTSD prevalence and predictors of PCL-C scores were different between the AA homozygotes and G allele carriers at different time during the follow-up. These results suggest gene-environment interactions may occur among rs9340799 and social-environmental factors, and influence the development and natural rehabilitation of PTSD in the course after stressed by the earthquake.

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Sex Steroid Hormone Pathway Genes and Health-Related Measures in Women of 4 Races/Ethnicities: The Study of Women’s Health Across the Nation (SWAN)

Cited by 43 publications

References 24 publications

Estrogen receptor alpha gene variants and major depressive episodes

Estrogen receptor alpha gene variants and major depressive episodes

A proposal research for new health check-up items focusing on the future super-aging society in Japan

Longitudinal interplays of estrogen receptor alpha gene rs9340799 with social‐environmental factors on post‐traumatic stress disorder in Chinese Han adolescents after Wenchuan earthquake

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