A proposal research for new health check-up items focusing on the future super-aging society in Japan

Nishizaki, Yasuhiro; Kubo, Akira; Kuwahira, Ichiro; Tanino, Ryuzaburo; Ogawa, Tetsuhei; Ishii, Naoaki

doi:10.7143/jhep.38.537

Cited by 8 publications

(10 citation statements)

References 31 publications

(51 reference statements)

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“…This prohormone serves as an initial substance in the synthesis of sex steroid hormones, namely, androgens and estrogens [ 1 ]. DHEAs has been thought to be a biomarker of aging because its serum level peaks in young adulthood and significantly decreases with aging (2%–3% per year) [ [2] , [3] , [4] ]. Recently, DHEAs have attracted considerable attention because the decline in serum DHEAs levels with advancing age is related to age-related diseases or with the deterioration of physiological functions [ 5 ] such as cognitive function [ 6 ], depression [ 7 ], cardiovascular disease [ 8 ], osteoporosis [ 9 ], and cancer [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Correlation of age and sex with urine dehydroepiandrosterone sulfate level in healthy Thai volunteers

Krorakai

Tontipattananon

Leemahanil

et al. 2021

Practical Laboratory Medicine

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Objective Dehydroepiandrosterone sulfate (DHEAs), a prohormone secreted by the adrenal gland, plays a role in the synthesis of sex hormones, namely, androgen and estrogen. It has been found that the amount of DHEAs is correlated with age, although most studies have focused on the correlation of serum DHEAs levels with age and sex. Thus, this noninvasive, cross-sectional study aimed to investigate the correlation of urine DHEAs levels with age and sex in healthy Thai volunteers aged 20–80 years. Methods DHEAs levels were measured in 178 healthy volunteers using electrochemiluminescence immunoassay and then normalized by creatinine. Multiple regression was performed to determine the correlation of urine DHEAs levels normalized by creatinine with age and sex. Results The normalized DHEAs levels are correlated with age group for both sexes. Moreover, an increasing trend in DHEAs levels was found in the age group 20–29 years, and the DHEAs level peaked at the age group 30–39 years before declining with advancing age. Based on the multiple regression analyses, the significance of the interaction term ( P < 0.05) indicates that both age and sex significantly contribute to the prediction of ln (DHEAs/Creatinine). Our fitted model implies the following: as age increases by 1 year, DHEAs/Creatinine is expected to decrease by 3.63% in females and by 2.18% in males. Conclusion This study reports more data on clinical reference value of urine DHEAs levels in healthy volunteers. Our result demonstrates urine DHEAs levels are associated with age and sex and decline by 2–3% a year.

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Section: Introductionmentioning

confidence: 99%

Correlation of age and sex with urine dehydroepiandrosterone sulfate level in healthy Thai volunteers

Krorakai

Tontipattananon

Leemahanil

et al. 2021

Practical Laboratory Medicine

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“…This research was very useful in that we were able to confirm, in the same group of Japanese individuals, factors strongly correlated with advancing age, as well as surrogate markers for its effects. This enabled us to give guidance based on aging-related physiological changes 3) .…”

Section: Check-up Systemmentioning

confidence: 99%

Retrospective on nine years of the Anti-Aging Health Check-ups in Tokai University Tokyo Hospital: From establishment to future

Nishizaki

Yamada

Kishimoto

et al. 2015

HEP

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In June 2006, Tokai University launched the Check-up System at the Tokyo Hospital with the aim of assessing agerelated changes and various factors that influence their progression, and following up with medical intervention. Prior to launching this Anti-Aging Health Check-up System, we conducted a questionnaire survey of individuals who had received general health check-ups at our hospital. More than 90% of the respondents knew about anti-aging medicine and were interested in it. The tests carried out as part of our anti-aging health check-ups are broadly divided into those that indicate the present degree of aging and those that focus on factors that contribute to aging. Our Anti-Aging Health Checkup System includes more than 70 examination items and provides various unique services.As of March 2015, approximately 1,640 individuals had received the anti-aging health check-up, and 75.4% of these were repeat recipients. The average age is currently 63.7 years for males and 61.7 for females. The gender ratio is 54% male compared to 46% female. Of the total number of recipients, 57% also received a general health check-up at the same time. By age group, individuals in their 60s account for the largest proportion with one-third of the total, and more than 80% of all those tested are aged 50 to 70. Some individuals have finished their 9th check-up, and many of them have kept aging-related markers steady or actually improved them.The rationale of the Anti-Aging Health Check-up System, which assumes advancing age to be the biggest risk factor for disease and aims to identify signs and intervene at an early stage, is considered an appropriate step in the right direction in terms of primary prevention. However, it may not always be possible to clearly convey its importance due to its complex nature. To properly develop this aspect, it should always be based on evidence with the target of extending life expectancy; it should be judged objectively, without ignoring conflicting evidence, while sufficient information should be provided and options offered to those receiving the check-ups. In view of the super-aging society, we hope that this kind of health assessment and guidance method will take root and flourish.

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“…The expressions "thin" and "thick" are generally used in connection with blood, but besides the fluidity of blood, we also carry out various other tests to predict the occurrence and progression of disease (biomarkers) which are not measured in ordinary check-ups. A disturbance in the balance of serum lipids can accelerate the progression of arteriosclerosis 10) .…”

Section: (2) Items Which Influence the Progress Of Arterial Sclerosismentioning

confidence: 99%

“…2 shows categories of "level of aging" and "aging risk factors" designated by the Japanese Society of AntiAging Medicine is shown in. Table 1 lists different tests conducted for anti-aging health check-up at the Tokai University Tokyo Hospital 10,11) .…”

Section: Examination Items Carried Out In Anti-aging Health Checkupsmentioning

confidence: 99%

Anti-aging health check-up system

Nishizaki

Kubo

Kuwahira

et al. 2012

HEP

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There are two words for "aging" in Japanese: karei and rōka. While karei simply means "increasing age", a Japanese dictionary defines rōka as "(1) Senescence; a decline in bodily functions due to increasing age. (2) Deterioration of the functions and properties of living organisms and substances with the passage of time". As such, rōka is closer in nuance to the English word "aging". All things existing in this world share the fate of suffering "negative change" accompanying the passage of time. This not only affects animate objects; the same is true of inanimate objects. In the case of animate objects, this negative change which is a universal, intrinsic, progressive and deleterious process is called "aging" 1) ; when dealing with inanimate objects, it is covered by a number of terms including oxidation, degradation, degeneration and decay.The mechanism of aging is notionally divided into physical aging and biological aging. Physical aging is governed by the passage of time and advances at a relatively regular speed under certain environmental conditions. Biological aging is associated with life activity and, as such, is unique to animate objects; a typical example would be the free radicals that arise as a result of breathing. Biological aging has a modifying effect on physical aging, sometimes accelerating it, sometimes slowing it down 2) . The authors speculate that the direct causes of the negative change of declining physical and philological functions can be more easily understood in terms of the human lifespan and changes in the somatic cell count, such as atrophic change caused by apoptosis. In the course of a person's life, the peak of bodily REVIEW ARTICLES ABSTRACTThe concept of "anti-aging medicine" as a means of intervening in and controlling the aging process is a relatively new medical field. One of the major aims of anti-aging medicine is to reduce susceptibility to diseases and death caused by aging. In that sense, anti-aging medicine is a further development of "preventive medicine", which relies on various forms of medical support to reduce or remove negative changes, both physical and mental, due to increasing age.The purpose of anti-aging health check-ups is to extend healthy life expectancy as well as longevity. Thus, a check-up can only be called an "anti-aging" check-up if the person undergoing it also receives proper health guidance based on the results of the examination. Tokai University Tokyo Hospital started offering anti-aging health check-ups in June 2006, since when more than 1,100 people have received one. We have confirmed clear improvements in age-related changes following guidance for a number of items.The ultimate target of preventive medicine is to promote health and longevity through medical intervention, such as various tests and health guidance before the occurrence of problems, or in asymptomatic periods. It is classified into primary prevention, secondary prevention and tertiary prevention, depending on the timing and stage of intervention. Currently, for example, the...

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A proposal research for new health check-up items focusing on the future super-aging society in Japan

Cited by 8 publications

References 31 publications

Correlation of age and sex with urine dehydroepiandrosterone sulfate level in healthy Thai volunteers

Correlation of age and sex with urine dehydroepiandrosterone sulfate level in healthy Thai volunteers

Retrospective on nine years of the Anti-Aging Health Check-ups in Tokai University Tokyo Hospital: From establishment to future

Anti-aging health check-up system

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