Sex-specific walking kinematics and kinetics in individuals with unilateral, symptomatic hip osteoarthritis: A cross sectional study

Allison, Kim; Hall, Michelle; Wrigley, Tim V.; Pua, Yong-Hao; Metcalf, Ben; Bennell, Kim L

doi:10.1016/j.gaitpost.2018.07.179

Cited by 15 publications

(13 citation statements)

References 36 publications

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“…Apart from a single study where no differences were found in any gait kinematic variable between OA and healthy patients in either men or women [ 43 ], all other studies showed gender differences. Men walked with a greater forward trunk lean and had greater peak hip external rotation moment than women [ 44 ]. However, women had a greater external hip adduction moment throughout stance than men [ 44 , 45 ].…”

Section: Resultsmentioning

confidence: 99%

Gender and Sex Are Key Determinants in Osteoarthritis Not Only Confounding Variables. A Systematic Review of Clinical Data

Tschon

Contartese

Pagani

et al. 2021

JCM

118

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Many risk factors for osteoarthritis (OA) have been noted, while gender/sex differences have been understated. The work aimed to systematically review literature investigating as primary aim the relationship between gender/sex related discriminants and OA. The search was performed in PubMed, Science Direct and Web of Knowledge in the last 10 years. Inclusion criteria were limited to clinical studies of patients affected by OA in any joints, analyzing as primary aim gender/sex differences. Exclusion criteria were review articles, in vitro, in vivo and ex vivo studies, case series studies and papers in which gender/sex differences were adjusted as confounding variable. Of the 120 records screened, 42 studies were included. Different clinical outcomes were analyzed: morphometric differences, followed by kinematics, pain, functional outcomes after arthroplasty and health care needs of patients. Women appear to use more health care, have higher OA prevalence, clinical pain and inflammation, decreased cartilage volume, physical difficulty, and smaller joint parameters and dimensions, as compared to men. No in-depth studies or mechanistic studies analyzing biomarker differential expressions, molecular pathways and omic profiles were found that might drive preclinical and clinical research towards sex-/gender-oriented protocols.

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Section: Resultsmentioning

confidence: 99%

Gender and Sex Are Key Determinants in Osteoarthritis Not Only Confounding Variables. A Systematic Review of Clinical Data

Tschon

Contartese

Pagani

et al. 2021

JCM

118

View full text Add to dashboard Cite

show abstract

“…A number of applications were presented throughout this paper. Additional interest has been noted in osteoarthritis [ 88 , 89 ], patellofemoral pain [ 90 ], military training [ 91 , 92 ], shoe design [ 93 ], and multiple sclerosis [ 94 ], to name just a few.…”

Section: Discussionmentioning

confidence: 99%

Whole body kinematic sex differences persist across non-dimensional gait speeds

et al. 2020

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Sex differences in human locomotion are of interest in a broad variety of interdisciplinary applications. Although kinematic sex differences have been studied for many years, the underlying reasons behind several noted differences, such as pelvis and torso range of motion, are still not well understood. Walking speed and body size in particular represent confounding influences that hinder our ability to determine causal factors. The purpose of this study was to investigate sex differences in whole body gait kinematics across a range of controlled, non-dimensional walking and running speeds. We hypothesized that as task demand (i.e. gait speed) increased, the influences of modifiable factors would decrease, leading to a kinematic motion pattern convergence between sexes. Motion capture data from forty-eight healthy young adults (24 M, 24 F) wearing controlled footwear was captured at three walking and three running Froude speeds. Spatiotemporal metrics, center of mass displacement, and joint/segment ranges of motion were compared between sexes using 2x6 mixed-model ANOVAs. Three dimensional time-series waveforms were also used to describe the timevarying behavior of select joint angles. When controlling for size, sex differences in spatiotemporal metrics and center of mass displacement disappeared. However, contrary to our hypothesis, sagittal plane ankle, frontal plane pelvis, and transverse plane pelvis and torso range of motion all displayed sex differences that persisted or increased with gait speed. Overall, most spatiotemporal sex differences appear to be related to size and self-selection of gait speeds, while in contrast, sex differences in joint motion may be more inherent and ubiquitous than previously thought. Discussion on potential causal factors is presented.

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“…Due to the low number of cases, we were not able to take gender into account in our study, as was done by Than et al [34], who found differences between the sexes in terms of leg alignment. Furthermore, Foucher et al [50] and Allison et al [48] were able to report higher hip adduction moments in women compared to men with hip OA. The hip and knee adduction moments are still the gold standards for assessing the load in the frontal plane; however, the joint contact force, calculated using musculoskeletal modeling, is likely a better indicator of joint load compared to joint moments.…”

Section: Discussionmentioning

confidence: 93%

“…A gait compensation pattern of a stable or elevated pelvis, in combination with an increased trunk lean toward the involved side, was shown by Thurston [46] in individuals with hip OA and by Westhoff et al [47] in children with Legg Calvé Perthes disease as a compensating strategy to reduce the hip load. However, an increased contralateral trunk lean associated with an increased pelvic drop was also shown in individuals with hip OA [46,48]; hence, the presence of these different combined movements may have confounded the correlation between the single movements and the external hip joint moments. Furthermore, Linley et al [49] found that only a thorough biomechanical analysis using a principal component analysis could reveal differences in the trunk and pelvic leans.…”

Section: Discussionmentioning

confidence: 99%

Determination of Leg Alignment in Hip Osteoarthritis Patients with the EOS® System and the Effect on External Joint Moments during Gait

et al. 2020

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The present study considered the entire leg alignment and links static parameters to the external joint moments during gait in patients with hip osteoarthritis. Eighteen patients with unilateral hip osteoarthritis were measured using the EOS® system. Clinical leg alignment and femoral parameters were extracted from the 3D reconstruction of the EOS images. A 3D gait analysis was performed and external knee and hip adduction moments were computed and compared to 18 healthy controls in the same age group. The knee adduction moments of the involved leg were strongly correlated to the femoral offset and the varus/valgus alignment. These parameters alone explained over 50% of the variance in the knee adduction moments. Adding the pelvic drop of the contralateral side increased the model of femoral offset and varus/valgus alignment and explained 78% of the knee adduction moment during the first half of the stance. The hip adduction moments were best associated with the hip kinematics and not the leg alignment.

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Sex-specific walking kinematics and kinetics in individuals with unilateral, symptomatic hip osteoarthritis: A cross sectional study

Cited by 15 publications

References 36 publications

Gender and Sex Are Key Determinants in Osteoarthritis Not Only Confounding Variables. A Systematic Review of Clinical Data

Gender and Sex Are Key Determinants in Osteoarthritis Not Only Confounding Variables. A Systematic Review of Clinical Data

Whole body kinematic sex differences persist across non-dimensional gait speeds

Determination of Leg Alignment in Hip Osteoarthritis Patients with the EOS® System and the Effect on External Joint Moments during Gait

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