Sex-specific metabolic profiles of androgens and its main binding protein SHBG in a middle aged population without diabetes

Piontek, Uwe; Wallaschofski, Henri; Kastenmüller, Gabi; Suhre, Karsten; Völzke, Henry; Trinh, Kieu; Artati, Anna; Nauck, Matthias; Adamski, Jerzy; Friedrich, Nele; Pietzner, Maik

doi:10.1038/s41598-017-02367-y

Cited by 12 publications

(3 citation statements)

References 71 publications

(82 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Non-targeted metabolomics analysis for metabolic profiling was conducted at the Genome Analysis Center, Helmholtz Zentrum München. A detailed description of metabolite measurements, annotations and data processing is given elsewhere 64,65 and in the Supplemental Information. After preprocessing 475 plasma and 558 urine metabolites remained for the statistical analyses.…”

Section: Measurementsmentioning

confidence: 99%

Associations between adipose tissue volume and small molecules in plasma and urine among asymptomatic subjects from the general population

Otto

Budde

Kastenmüller

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

obesity is one of the major risk factor for cardiovascular and metabolic diseases. A disproportional accumulation of fat at visceral (VAt) compared to subcutaneous sites (SAt) has been suspected as a key detrimental event. We used non-targeted metabolomics profiling to reveal metabolic pathways associated with higher VAt or SAt amount among subjects free of metabolic diseases to identify possible contributing metabolic pathways. The study population comprised 491 subjects [mean (standard deviation): age 44.6 yrs (13.0), body mass index 25.4 kg/m² (3.6), 60.1% females] without diabetes, hypertension, dyslipidemia, the metabolic syndrome or impaired renal function. We associated MRi-derived fat amounts with mass spectrometry-derived metabolites in plasma and urine using linear regression models adjusting for major confounders. We tested for sex-specific effects using interactions terms and performed sensitivity analyses for the influence of insulin resistance on the results. VAT and SAT were significantly associated with 155 (101 urine) and 49 (29 urine) metabolites, respectively, of which 45 (27 urine) were common to both. Major metabolic pathways were branched-chain amino acid metabolism (partially independent of insulin resistance), surrogate markers of oxidative stress and gut microbial diversity, and cortisol metabolism. We observed a novel positive association between VAt and plasma levels of the potential pharmacological agent piperine. Sex-specific effects were only a few, e.g. the female-specific association between VAT and O-methylascorbate. In brief, higher VAT was associated with an unfavorable metabolite profile in a sample of healthy, mostly non-obese individuals from the general population and only few sex-specific associations became apparent. equal amount of unknown compounds showed significant associations with VAT, including those related to either cortisol or piperine in the derived metabolic network (Fig. 3).Plasma and urine metabolites associated with SAT. Almost all association between SAT and metabolites were already described for VAT. Within each fluid, only two significant observations were unique to SAT (Figs. 1 and 2). Cortisol (inversely) and N1-methyl-2-pyridone-5-carboxamide (positively) levels in plasma as well as 3′-sialyllactose and the unknown compound X-12840 (both positively) levels in urine associated with SAT.

show abstract

Section: Measurementsmentioning

confidence: 99%

Associations between adipose tissue volume and small molecules in plasma and urine among asymptomatic subjects from the general population

Otto

Budde

Kastenmüller

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…[ 38,39 ] This might be due to the biological activity of piperine or other dietary or lifestyle factors associated with piperine intake. Piperine has also been positively associated with amount of adipose tissue [ 45 ] and inversely associated with Alzheimer's disease [ 46 ] and blood levels of sex hormones [ 47 ] and the authors linked these outcomes to potential physiological effects of piperine. The results of the present study show that piperine levels are influenced by the intake of processed meat and more particularly sausages.…”

Section: Discussionmentioning

confidence: 99%

Pepper Alkaloids and Processed Meat Intake: Results from a Randomized Trial and the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort

Wedekind

Keski‐Rahkonen

Robinot

et al. 2021

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Scope Processed meat intake has been associated with adverse health outcomes. However, little is known about the type of processed meat more particularly responsible for these effects. This study aims to identify novel biomarkers for processed meat intake. Methods and Results In a controlled randomized cross‐over dietary intervention study, 12 healthy volunteers consume different processed and non‐processed meats for 3 consecutive days each. Metabolomics analyses are applied on post‐intervention fasting blood and urine samples to identify discriminating molecular features of processed meat intake. Nine and five pepper alkaloid metabolites, including piperine, are identified as major discriminants of salami intake in urine and plasma, respectively. The associations with processed meat intake are tested for replication in a cross‐sectional study (n = 418) embedded within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Three of the serum metabolites including piperine are associated with habitual intake of sausages and to a lesser extent of total processed meat. Conclusion Pepper alkaloids are major discriminants of intake for sausages that contain high levels of pepper used as ingredient. Further work is needed to assess if pepper alkaloids in combination with other metabolites may serve as biomarkers of processed meat intake.

show abstract

“…In an epidemiological study, a statistically significant inverse association was observed between plasma testosterone concentrations and, among others, plasma piperine levels in healthy middle-aged men (median: 50 years) [ 119 ]. However, as already mentioned by the study authors, a statistical association does not imply causality and therefore the scientific significance of these data from this particular study alone regarding male reproductive effects remains elusive (i.e., piperine plasma levels could just be a lifestyle marker).…”

Section: Safety Aspectsmentioning

confidence: 99%

Safety Aspects of the Use of Isolated Piperine Ingested as a Bolus

Ziegenhagen

Heimberg

Lampen

et al. 2021

Foods

View full text Add to dashboard Cite

Piperine is a natural ingredient of Piper nigrum (black pepper) and some other Piper species. Compared to the use of pepper for food seasoning, piperine is used in food supplements in an isolated, concentrated form and ingested as a bolus. The present review focuses on the assessment of the possible critical health effects regarding the use of isolated piperine as a single ingredient in food supplements. In human and animal studies with single or short-term bolus application of isolated piperine, interactions with several drugs, in most cases resulting in increased drug bioavailability, were observed. Depending on the drug and extent of the interaction, such interactions may carry the risk of unintended deleteriously increased or adverse drug effects. Animal studies with higher daily piperine bolus doses than in human interaction studies provide indications of disturbance of spermatogenesis and of maternal reproductive and embryotoxic effects. Although the available human studies rarely reported effects that were regarded as being adverse, their suitability for detailed risk assessment is limited due to an insufficient focus on safety parameters apart from drug interactions, as well as due to the lack of investigation of the potentially adverse effects observed in animal studies and/or combined administration of piperine with other substances. Taken together, it appears advisable to consider the potential health risks related to intake of isolated piperine in bolus form, e.g., when using certain food supplements.

show abstract

Sex-specific metabolic profiles of androgens and its main binding protein SHBG in a middle aged population without diabetes

Cited by 12 publications

References 71 publications

Associations between adipose tissue volume and small molecules in plasma and urine among asymptomatic subjects from the general population

Associations between adipose tissue volume and small molecules in plasma and urine among asymptomatic subjects from the general population

Pepper Alkaloids and Processed Meat Intake: Results from a Randomized Trial and the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort

Safety Aspects of the Use of Isolated Piperine Ingested as a Bolus

Contact Info

Product

Resources

About