Sex-Specific Exposure–Effect Relationship Between Physical Activity and Incident Atrial Fibrillation in the General Population: A Dose–Response Meta-Analysis of 16 Prospective Studies

Wan, Qin; Zhou, Yue; Zhu, Wenzhen

doi:10.3389/fcvm.2021.710071

Cited by 10 publications

(9 citation statements)

References 52 publications

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“…A recent meta-analysis of 15 prospective studies, including 1,464,539 individuals, showed that PA engagement was associated with the decreased risk of AF 0.94 (0.90, 0.97) [ 8 ]. Another recent dose-response meta-analysis of 16 prospective studies, involving 1,449,017 individuals, showed that an increase of five metabolic equivalents of task-hour/week in PA was associated with the reduced risk of AF 0.992 (0.988, 0.996) [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Stair climbing and incident atrial fibrillation: a prospective cohort study

Arafa

Kokubo

Shimamoto

et al. 2022

Environ. Health Prev. Med.

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Background A protective role for physical activity against the development of atrial fibrillation (AF) has been suggested. Stair climbing is a readily available form of physical activity that many people practice. Herein, we investigated the association between stair climbing and the risk of AF in a Japanese population. Methods In this prospective cohort study, we used data of 6,575 people registered in the Suita Study, aged 30–84 years, and had no history of AF. The frequency of stair climbing was assessed by a baseline questionnaire, while AF was diagnosed during the follow-up using a 12-lead ECG, health records, check-ups, and death certificates. We used the Cox regression to calculate the hazard ratios and 95% confidence intervals of AF incidence for climbing stairs in 20–39%, 40–59%, and ≥60% compared with <20% of the time. Results Within 91,389 person-years of follow-up, 295 participants developed AF. The incidence of AF was distributed across the stair climbing groups <20%, 20–39%, 40–59%, and ≥60% as follows: 3.57, 3.27, 3.46, and 2.63/1,000 person-years, respectively. Stair climbing ≥60% of the time was associated with a reduced risk of AF after adjustment for age and sex 0.69 (0.49, 0.96). Further adjustment for lifestyle and medical history did not affect the results 0.69 (0.49, 0.98). Conclusion Frequent stair climbing could protect from AF. From a preventive point of view, stair climbing could be a simple way to reduce AF risk at the population level. Supplementary information The online version contains supplementary material available at https://doi.org/10.1265/ehpm.21-00021 .

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Section: Discussionmentioning

confidence: 99%

Stair climbing and incident atrial fibrillation: a prospective cohort study

Arafa

Kokubo

Shimamoto

et al. 2022

Environ. Health Prev. Med.

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“…Through subgroup analysis, among participants with MUO, the modification of PA on AF risk was significantly higher in females than that in males. Wan et al showed that females reporting PA had lower AF incidence [43]. One possible mechanism was that the appropriate level of PA for males was higher than for females, while a high level of PA may decrease the modification of PA on the Fig.…”

Section: Discussionmentioning

confidence: 99%

Association between metabolically healthy obesity and risk of atrial fibrillation: taking physical activity into consideration

Wang

Olier

Ortega‐Martorell

et al. 2022

Cardiovasc Diabetol

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The modification of physical activity (PA) on the metabolic status in relation to atrial fibrillation (AF) in obesity remains unknown. We aimed to investigate the independent and joint associations of metabolic status and PA with the risk of AF in obese population. Based on the data from UK Biobank study, we used Cox proportional hazards models for analyses. Metabolic status was categorized into metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO). PA was categorized into four groups according to the level of moderate-to-vigorous PA (MVPA): none, low, medium, and high. A total of 119,424 obese participants were included for analyses. MHO was significantly associated with a 35% reduced AF risk compared with MUO (HR = 0.65, 95% CI: 0.57–0.73). No significant modification of PA on AF risk among individuals with MHO was found. Among the MUO participants, individuals with medium and high PA had significantly lower AF risk compared with no MVPA (HR = 0.84, 95% CI: 0.74–0.95, and HR = 0.87, 95% CI: 0.78–0.96 for medium and high PA, respectively). As the severity of MUO increased, the modification of PA on AF risk was elevated accordingly. To conclude, MHO was significantly associated with a reduced risk of AF when compared with MUO in obese participants. PA could significantly modify the relationship between metabolic status and risk of AF among MUO participants, with particular benefits of PA associated with the reduced AF risk as the MUO severity elevated.

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“…It required at least two categories of coffee intake and the corresponding risk estimates with variance estimates. For these studies with no median or mean coffee intake level in each category, the midpoint of each category was estimated ( 21 , 22 ). If the highest or lowest category was open-ended, the open-ended interval length was assumed to be that of the adjacent interval ( 21 , 22 ).…”

Section: Methodsmentioning

confidence: 99%

Association of Coffee Consumption With Atrial Fibrillation Risk: An Updated Dose–Response Meta-Analysis of Prospective Studies

Cao

Liu

Xue

et al. 2022

Front. Cardiovasc. Med.

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BackgroundSeveral published studies have examined the association of coffee consumption with atrial fibrillation (AF) risk, but their findings are still controversial. Therefore, we performed a systematic review and dose–response meta-analysis of prospective studies to determine the relationship between coffee consumption and the risk of incident AF.MethodsWe systematically retrieved the PubMed and Embase databases until October 2021 for pertinent studies that reported the association of coffee consumption (caffeinated or decaffeinated coffee) with AF risk. A cubic spline random-effects model was used to fit the potential dose–response curve. The effect estimates were expressed as adjusted risk ratios (RRs) and 95% CIs.ResultsA total of 10 prospective studies (11 cohorts) involving 30,169 AF events and 723,825 participants were included. In the dose–response analysis, there was a linear inverse association between coffee intake and risk of AF although not statistically significant (Pnon–linearity = 0.25). Compared with participants with no coffee consumption, the RRs (95% CI) of AF risk estimated directly from the dose–response curve were 1.01 (0.98–1.03), 1.00 (0.97–1.04), 0.99 (0.92–1.02), 0.95 (0.89–1.01), 0.94 (0.87–1.01), 0.89 (0.79–1.02), and 0.87 (0.76–1.02) for 1–7 cups of coffee per day, respectively. One cup per day increased in coffee consumption was associated with a 2% reduced risk of AF (RR = 0.98, 95% CI: 0.97–1.00, P = 0.02).ConclusionsOur evidence from this meta-analysis suggested that coffee consumption had a trend toward reducing the risk of AF in a dose–response manner. Further studies could be conducted to reinforce our findings.

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Sex-Specific Exposure–Effect Relationship Between Physical Activity and Incident Atrial Fibrillation in the General Population: A Dose–Response Meta-Analysis of 16 Prospective Studies

Cited by 10 publications

References 52 publications

Stair climbing and incident atrial fibrillation: a prospective cohort study

Stair climbing and incident atrial fibrillation: a prospective cohort study

Association between metabolically healthy obesity and risk of atrial fibrillation: taking physical activity into consideration

Association of Coffee Consumption With Atrial Fibrillation Risk: An Updated Dose–Response Meta-Analysis of Prospective Studies

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