Sex-specific association between placental inflammatory cytokine mRNA expression and preschoolers’ behavioral development: The Ma’anshan birth cohort study

Zhou, Jixing; Teng, Yuzhu; Zhang, Fu; Ru, Xue; Li, Peixuan; Wang, Jianqing; Yan, Shuangqin; Zhu, Peng; Tao, Fangbiao; Huang, Kun

doi:10.1016/j.bbi.2022.05.017

Cited by 6 publications

(1 citation statement)

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“…Women (age > 18 years and gestational age < 14 weeks) who planned to undergo prenatal and childbirth follow-up visits at the Maternal and Child Health Center in Ma’anshan City were recruited from May 2013 to September 2014. The detailed inclusion criteria were described in our previous study [ 14 ]. Additional exclusion criteria for this study were as follows: (1) adverse pregnancy outcomes (embryo arrest, spontaneous abortion, therapeutic abortion, stillbirth, and ectopic pregnancy) (n = 162) and multiple pregnancies (n = 39); (2) children with missing information on birth weight or gestational age (n = 14); (3) children whose BMI was recorded less than six times from birth to six years of age (n = 554) (that is less than twice from 0 to 9 months; less than twice from 12 to 36 months and less than twice from 42 to 72 months).…”

Section: Methodsmentioning

confidence: 99%

Birth outcomes and early growth patterns associated with age at adiposity rebound: the Ma’anshan birth cohort (MABC) study

Zhou,

Teng,

Zhang

et al. 2023

BMC Public Health

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ObjectiveEarly onset of adiposity rebound (AR) is considered an early indicator of obesity risk. Our objective was to investigate the association of birth outcomes and early physical growth patterns with early AR in children.MethodsStudy subjects (n = 2705) were enrolled from the Ma’anshan birth cohort (MABC). The body mass index (BMI), head circumference, waist circumference, and body fat were collected. Rapid weight gain (RWG) was defined by the change in weight standard-deviation score in the first two years of life. Group-based trajectory modeling (GBTM) was used to determine children’s physical growth trajectories. The age of AR was fitted using fractional polynomial function models.ResultsChildren with very high BMI trajectories (RR = 2.83; 95% CI 2.33 to 1.40), rising BMI trajectories (RR = 3.15; 95% CI 2.66 to 3.72), high waist circumference trajectories (RR = 4.17; 95% CI 3.43 to 5.06), and high body fat trajectories (RR = 3.01; 95% CI 2.62 to 3.46) before 72 months of age were at a greater risk of experiencing early AR. Low birth weight (LBW) (RR = 1.86; 95% CI 1.28 to 2.51), preterm birth (PTB) (RR = 1.50; 95% CI 1.17 to 1.93), and small for gestational age (SGA) (RR = 1.37; 95% CI 1.14 to 1.64) associated with increased risk of early AR. Moreover, infants experiencing RWG (RR = 1.59; 95% CI 1.40 to 1.83), low BMI trajectories (RR = 1.27; 95% CI 1.06 to 1.53) and rising BMI trajectories (RR = 1.50; 95% CI 1.22 to 1.84) in the first two years were at higher risk of developing early AR subsequently. Compared to the group with non-early AR, the BMI of children with early AR tended to be lower first (from birth to 6 months of age) and then higher (from 18 to 72 months of age).ConclusionsChildren with overall high BMI, high waist circumference, and high body fat before 72 months of age are more likely to experience early AR, but infants with low BMI trajectories, rising BMI trajectories and infants experiencing RWG in the first two years of life similarly increase the risk of early AR. These results can help to understand the early factors and processes that lead to metabolic risks.

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Section: Methodsmentioning

confidence: 99%