Sex-Related Differences in Anxious-Depressive and Defensive Behavior in Wistar Rats

Павлова, И. В.; Broshevitskaya, N. D.; Онуфриев, М. В.; Moiseeva, Yu. V.

doi:10.1007/s11055-020-01028-4

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…Temporal analysis of time spent divided in smaller discrete time bins compared to the commonly used EPM measure of total time spent in open arms for the 5 minutes trial duration might provide a nuanced insight to sex-specific anxiety and risky preference of open arm. Our results indicate the possibility of high anxiety regulation in females and increase in risk-taking, our results corroborate with the rare reports of females exhibiting less anxious behaviour on the EPM (Pavlova et al 2020; Knight et al, 2021; Bonuti and Murato, 2022).…”

Section: Discussionsupporting

confidence: 92%

“…Therefore, we expect that detailed analysis of spatial and temporal aspects of EPM might improve our understanding of sex-differences in anxiety, for instance, modified EPM (elevated gradient of aversion, EGA) using shortened trial duration to 3 min indicated female rats might be less anxious compared to male counterparts (Bonuti, 2022). Donner and Lowry, 2013; Pavlova et. al, 2020; Knight et.al, 2021 have also reported similar differences in the two sexes with females showing less anxious behavior on the maze.…”

Section: Introductionmentioning

confidence: 99%

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Examining Anxiety and Risk-taking in Healthy Male and Female Wistar Rats using Spatial and Temporal Analysis of Elevated Plus Maze

Sharma¹,

Pandey²,

Jain

et al. 2022

Preprint

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The Elevated Plus Maze (EPM) offers a standard set up for understanding anxiety, unconditioned risk-avoidance in rodents. The animal shows a preference for enclosed safe arms and avoids risky, open arms that evoke anxiety due to elevated platform (unconditioned response to elevation). A few rodent studies aiming to understand sex-skewed representation in anxiety disorders use the maze and report that more females compared to males show high levels of anxiety and risk-avoidance on an elevated platform. Ethograms derived from examining animal behaviour in the EPM provide precise measures of behaviour of interest, enabling objective assessment of anxiety and risk behaviour. We report two new parameters that might be critical for quantitative analysis of EPM task as a measure of anxiety with reference to sex-differences in risk-taking: (a) spatial preference for arms (open & closed) (b) temporal shift in arm preference in task trials. We first report results from the conventionally derived measures confirming that males spent more time in the open arms indicating low anxiety and higher risk-taking. Preferences for the two open and two closed arms were non-uniform for males and females; male showed stronger preference for one of the two risky open arms, and females showed a stronger preference for one of the two safe closed arms. Temporal analyses indicated that males spent more time in open arms in 3 out of 6 time bins (time blocks), and females spent more time in the closed arms in 5 out of 6 time bins (time blocks), however, counter-intuitively, females showed larger increase in time spent in open arms in the last phase potentially indicating greater regulation of anxiety and increased risk-taking. Inclusion of spatial and temporal parameters in EPM studies might improve our understanding of cognitive and biological sex differences pertaining to anxiety, and risky behavior.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Examining Anxiety and Risk-taking in Healthy Male and Female Wistar Rats using Spatial and Temporal Analysis of Elevated Plus Maze

Sharma¹,

Pandey²,

Jain

et al. 2022

Preprint

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show abstract

“…In contrast, Cottone et al (2007) found that female rats with FG-7142 at the dose used in the present study (7.5 mg/kg) had anxiogenic-like behavior in the elevated plusmaze. Sex differences have also been described in other anxiety and depression models (Kokras and Dalla, 2014;Pavlova et al, 2020). In studies comparing female vs. male rats in the elevated plus maze, female rodents exhibit less anxiety-like behavior (Mora et al, 1996;Díaz-Véliz et al, 1997;Fernandes et al, 1999;Walf and Frye, 2007).…”

Section: Discussionmentioning

confidence: 95%

Sex differences in amygdalohippocampal oscillations and neuronal activation in a rodent anxiety model and in response to infralimbic deep brain stimulation

Vila-Merkle

González-Martínez

Campos-Jiménez

et al. 2023

Front. Behav. Neurosci.

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IntroductionDepression and anxiety are highly comorbid mental disorders with marked sex differences. Both disorders show altered activity in the amygdala, hippocampus, and prefrontal cortex. Infralimbic deep brain stimulation (DBS-IL) has anxiolytic and antidepressant effects, but the underlying mechanisms remain unclear. We aimed to contribute to understanding sex differences in the neurobiology of these disorders.MethodsIn male and female rats, we recorded neural oscillations along the dorsoventral axis of the hippocampus and the amygdala in response to an anxiogenic drug, FG-7142. Following this, we applied DBS-IL.ResultsSurprisingly, in females, the anxiogenic drug failed to induce most of the changes observed in males. We found sex differences in slow, delta, theta, and beta oscillations, and the amygdalo-hippocampal communication in response to FG-7142, with modest changes in females. Females had a more prominent basal gamma, and the drug altered this band only in males. We also analyzed c-Fos expression in both sexes in stress-related structures in response to FG-7142, DBS-IL, and combined interventions. With the anxiogenic drug, females showed reduced expression in the nucleus incertus, amygdala, septohippocampal network, and neocortical levels. In both experiments, the DBS-IL reversed FG-7142-induced effects, with a more substantial effect in males than females.DiscussionHere, we show a reduced response in female rats which contrasts with the higher prevalence of anxiety in women but is consistent with other studies in rodents. Our results open compelling questions about sex differences in the neurobiology of anxiety and depression and their study in animal models.

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Adolescent chronic unpredictable stress leads to increased anxiety and attention deficit/hyperactivity-like symptoms in adulthood

Kwarteng

Wang²,

Micov³

et al. 2022

Psychopharmacology

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Sex-Related Differences in Anxious-Depressive and Defensive Behavior in Wistar Rats

Cited by 5 publications

References 33 publications

Examining Anxiety and Risk-taking in Healthy Male and Female Wistar Rats using Spatial and Temporal Analysis of Elevated Plus Maze

Examining Anxiety and Risk-taking in Healthy Male and Female Wistar Rats using Spatial and Temporal Analysis of Elevated Plus Maze

Sex differences in amygdalohippocampal oscillations and neuronal activation in a rodent anxiety model and in response to infralimbic deep brain stimulation

Adolescent chronic unpredictable stress leads to increased anxiety and attention deficit/hyperactivity-like symptoms in adulthood

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